Francisco A. Tómas‐Barberán
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View article: Application of priming agents in red raspberries prior to transplantation and at pre-flowering stages results in improved yield efficiency and enhanced secondary metabolism
Application of priming agents in red raspberries prior to transplantation and at pre-flowering stages results in improved yield efficiency and enhanced secondary metabolism Open
Red raspberry (Rubus idaeus L) fruit has high nutritional value and there is an increasing demand in its global cultivation, highlighting the need for sustainable practices to improve both fruit and plant productivity. Chemical priming has…
View article: Novel Insights into the Human Gut Microbially Conjugated Bile Acids: The New Diversity of the Amino Acid-Conjugated Derivatives
Novel Insights into the Human Gut Microbially Conjugated Bile Acids: The New Diversity of the Amino Acid-Conjugated Derivatives Open
Bile acids (BAs) are biomolecules involved in lipids and glucose metabolism, and recently discovered microbially conjugated BAs (MCBAs) play an important role. Although the production of MCBAs amidated with amino acids (AA), similarly to t…
View article: Pre-harvest application of sodium alginate functionalized with melatonin enhances secondary metabolism in strawberry fruit
Pre-harvest application of sodium alginate functionalized with melatonin enhances secondary metabolism in strawberry fruit Open
The application of priming agents is a promising strategy to enhance the nutritional content of fruits and overall fruit quality. The current study aimed to assess the effect of the pre-harvest application of various priming agents [melato…
View article: The postharvest application of biodegradable polymers and a priming agent as a potential tool to enhance phytochemical content, aroma profile and market life of strawberry fruit
The postharvest application of biodegradable polymers and a priming agent as a potential tool to enhance phytochemical content, aroma profile and market life of strawberry fruit Open
View article: Evidence for a Modulatory Effect of a 12‐Week Pomegranate Juice Intervention on the Transcriptional Response in Inflammatory Bowel Disease Patients Reducing Fecal Calprotectin Levels: Findings From a Proof‐of‐Principle Study
Evidence for a Modulatory Effect of a 12‐Week Pomegranate Juice Intervention on the Transcriptional Response in Inflammatory Bowel Disease Patients Reducing Fecal Calprotectin Levels: Findings From a Proof‐of‐Principle Study Open
This study aimed at investigating the effects of pomegranate juice (POMJ) consumption on inflammatory biomarkers and gene expression in patients with inflammatory bowel disease (IBD) in clinical remission. In this randomized, placebo‐contr…
View article: Effect of environmental conditions on seed yield and metabolomic profile of camelina (Camelina sativa (L.) Crantz) through on farm multilocation trials
Effect of environmental conditions on seed yield and metabolomic profile of camelina (Camelina sativa (L.) Crantz) through on farm multilocation trials Open
Mediterranean farmers are searching for low input and alternative crops for cropping systems diversification and for promoting innovative value chains. Since there are still limited studies on camelina to be introduced under real on-farm c…
View article: Microbiota-derived urolithin A in monoclonal gammopathies and multiple myeloma therapy
Microbiota-derived urolithin A in monoclonal gammopathies and multiple myeloma therapy Open
UroA might be a potential therapeutic agent to halt MM disease progression or to overcome resistance when used in combination. Video Abstract.
View article: Extended recommendations on the nomenclature for microbial catabolites of dietary (poly)phenols, with a focus on isomers
Extended recommendations on the nomenclature for microbial catabolites of dietary (poly)phenols, with a focus on isomers Open
There is an increasing body of evidence indicating that phenolic compounds derived from microbiota-mediated breakdown of dietary (poly)phenolics in the colon are at least partially responsible for the beneficial effects of a plant-based di…
View article: Pathogenic NLRP3 mutants forms constitutively active inflammasomes resulting in immune-metabolic limitation of IL-1β production
Pathogenic NLRP3 mutants forms constitutively active inflammasomes resulting in immune-metabolic limitation of IL-1β production Open
Cryopyrin-associated periodic syndrome (CAPS) is an autoinflammatory condition resulting from monoallelic NLRP3 variants that facilitate IL-1β production. Although these are gain-of-function variants characterised by hypersensitivity to ce…
View article: How Diet and Lifestyle Can Fine-Tune Gut Microbiomes for Healthy Aging
How Diet and Lifestyle Can Fine-Tune Gut Microbiomes for Healthy Aging Open
Many physical, social, and psychological changes occur during aging that raise the risk of developing chronic diseases, frailty, and dependency. These changes adversely affect the gut microbiota, a phenomenon known as microbe-aging. Those …
View article: Exploring the fate of phlorotannins from Laminaria digitata across the gastrointestinal tract: Insights into susceptibility and bioactivity prior and post gastrointestinal digestion
Exploring the fate of phlorotannins from Laminaria digitata across the gastrointestinal tract: Insights into susceptibility and bioactivity prior and post gastrointestinal digestion Open
Phlorotannins are phenolic compounds exclusive from brown macroalgae endowed with promising bioactive properties. However, considering that diet is their main route of entrance to our system, gastrointestinal digestion might affect such bi…
View article: Using Targeted Metabolomics to Unravel Phenolic Metabolites of Plant Origin in Animal Milk
Using Targeted Metabolomics to Unravel Phenolic Metabolites of Plant Origin in Animal Milk Open
Milk holds a high nutritional value and is associated with diverse health benefits. The understanding of its composition of (poly)phenolic metabolites is limited, which necessitates a comprehensive evaluation of the subject. This study aim…
View article: Nav1.8-expressing neurons control daily oscillations of food intake, body weight and gut microbiota in mice
Nav1.8-expressing neurons control daily oscillations of food intake, body weight and gut microbiota in mice Open
View article: Author Correction: Mitophagy curtails cytosolic mtDNA-dependent activation of cGAS/STING inflammation during aging
Author Correction: Mitophagy curtails cytosolic mtDNA-dependent activation of cGAS/STING inflammation during aging Open
View article: Pathogenic NLRP3 mutants form constitutively active inflammasomes resulting in immune-metabolic limitation of IL-1β production
Pathogenic NLRP3 mutants form constitutively active inflammasomes resulting in immune-metabolic limitation of IL-1β production Open
Cryopyrin-associated periodic syndrome (CAPS) is an autoinflammatory condition resulting from monoallelic NLRP3 variants that facilitate IL-1β production. Although these are gain-of-function variants characterized by hypersensitivity to ce…
View article: Mitophagy curtails cytosolic mtDNA-dependent activation of cGAS/STING inflammation during aging
Mitophagy curtails cytosolic mtDNA-dependent activation of cGAS/STING inflammation during aging Open
View article: New findings in the metabolism of the saffron apocarotenoids, crocins and crocetin, by the human gut microbiota
New findings in the metabolism of the saffron apocarotenoids, crocins and crocetin, by the human gut microbiota Open
The transformation kinetics of the saffron apocarotenoids, crocin and crocetin by human gut microbiota has been described for the first time and several new crocetin-derived microbial metabolites were identified.
View article: MS/MS fragmentation pattern analysis confirms the production of the new esterified bile acids by the human gut microbiota
MS/MS fragmentation pattern analysis confirms the production of the new esterified bile acids by the human gut microbiota Open
The pathophysiology of bile acids (BAs) has been widely studied. The BAs are signaling molecules that affect lipids and glucose homeostasis via activation of BAs FRX and TGR5 receptors in the liver and peripheral tissues. The ratio of conj…
View article: P850: THE EFFECT OF UROLITHIN PRODUCTION BY GUT MICROBIOTA IN MULTIPLE MYELOMA
P850: THE EFFECT OF UROLITHIN PRODUCTION BY GUT MICROBIOTA IN MULTIPLE MYELOMA Open
Topic: 13. Myeloma and other monoclonal gammopathies - Biology & Translational Research Background: Recent studies have focused on understanding the role of the gut microbiota and its production of active metabolites in hematological malig…
View article: NMR Spectroscopic Identification of Urolithin G, a Novel Trihydroxy Urolithin Produced by Human Intestinal <i>Enterocloster</i> Species
NMR Spectroscopic Identification of Urolithin G, a Novel Trihydroxy Urolithin Produced by Human Intestinal <i>Enterocloster</i> Species Open
Urolithins are gut microbiota metabolites of ellagic acid. Here, we have identified and chemically characterized a novel urolithin produced from urolithin D (3,4,8,9-tetrahydroxy urolithin) by in vitro incubation with different human gut <…
View article: Ellagic acid and its metabolites urolithins A/B ameliorate most common disease phenotypes in cellular and mouse models for lysosomal storage disorders by enhancing extracellular vesicle secretion
Ellagic acid and its metabolites urolithins A/B ameliorate most common disease phenotypes in cellular and mouse models for lysosomal storage disorders by enhancing extracellular vesicle secretion Open
View article: Gut Bacteria Involved in Ellagic Acid Metabolism To Yield Human Urolithin Metabotypes Revealed
Gut Bacteria Involved in Ellagic Acid Metabolism To Yield Human Urolithin Metabotypes Revealed Open
We aimed to elucidate the gut bacteria that characterize the human urolithin metabotypes A and B (UM-A and UM-B). We report here a new bacterium isolated from the feces of a healthy woman, capable of producing the final metabolites urolith…
View article: In Memoriam, Vernon H. Heywood (1927-2022)
In Memoriam, Vernon H. Heywood (1927-2022) Open
View article: Separation of Isomeric Forms of Urolithin Glucuronides Using Supercritical Fluid Chromatography
Separation of Isomeric Forms of Urolithin Glucuronides Using Supercritical Fluid Chromatography Open
Urolithins are gut microbiota metabolites produced in humans after consuming foods containing ellagitannins and ellagic acid. Three urolithin metabotypes have been reported for different individuals depending on the final urolithins produc…
View article: Effect of Storage Conditions on the Stability of Polyphenols of Apple and Strawberry Purees Produced at Industrial Scale by Different Processing Techniques
Effect of Storage Conditions on the Stability of Polyphenols of Apple and Strawberry Purees Produced at Industrial Scale by Different Processing Techniques Open
During a food product's life, storage conditions affect its composition of nutrients, bioactive compounds, and sensory attributes. In this research, strawberry and apple purees were selected as a model to examine how the storage of various…
View article: Synthesis and Characterization of a Novel Resveratrol Xylobioside Obtained Using a Mutagenic Variant of a GH10 Endoxylanase
Synthesis and Characterization of a Novel Resveratrol Xylobioside Obtained Using a Mutagenic Variant of a GH10 Endoxylanase Open
Resveratrol is a natural polyphenol with antioxidant activity and numerous health benefits. However, in vivo application of this compound is still a challenge due to its poor aqueous solubility and rapid metabolism, which leads to an extre…
View article: Saffron against Neuro-Cognitive Disorders: An Overview of Its Main Bioactive Compounds, Their Metabolic Fate and Potential Mechanisms of Neurological Protection
Saffron against Neuro-Cognitive Disorders: An Overview of Its Main Bioactive Compounds, Their Metabolic Fate and Potential Mechanisms of Neurological Protection Open
Saffron (Crocus sativus L.) is a spice used worldwide as a colouring and flavouring agent. Saffron is also a source of multiple bioactive constituents with potential health benefits. Notably, saffron displays consistent beneficial effects …
View article: Biodegradation of Punicalagin into Ellagic Acid by Selected Probiotic Bacteria: A Study of the Underlying Mechanisms by MS-Based Proteomics
Biodegradation of Punicalagin into Ellagic Acid by Selected Probiotic Bacteria: A Study of the Underlying Mechanisms by MS-Based Proteomics Open
Pomegranate (Punica granatum L.) is a well-known source of bioactive phenolic compounds such as ellagitannins, anthocyanins, and flavanols. Punicalagin, one of the main constituents of pomegranate, needs to be biodegraded by bacteri…
View article: A Novel Integrative Methodology for Research on Pot-honey Variations During Post-harvest
A Novel Integrative Methodology for Research on Pot-honey Variations During Post-harvest Open
This novel review of analytical methods for pot-honey research was intended to provide concise references to a 35-day post-harvest experiments at 30 °C, in an integrated study. Diverse methods were selected from specialized literature, fro…
View article: A Novel Integrative Methodology for Research on Pot-honey Variations During Post-harvest
A Novel Integrative Methodology for Research on Pot-honey Variations During Post-harvest Open
This novel review of analytical methods for pot-honey research was intended to provide concise references to a 35-day post-harvest experiments at 30 °C, in an integrated study. Diverse methods were selected from specialized literature, fro…