Francisco R. Fields
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View article: Rationally Designed Minimal Bioactive Domains of AS-48 Bacteriocin Homologs Possess Potent Antileishmanial Properties
Rationally Designed Minimal Bioactive Domains of AS-48 Bacteriocin Homologs Possess Potent Antileishmanial Properties Open
Leishmaniasis is a neglected tropical disease caused by protozoan parasites of the genus Leishmania . There are three primary clinical forms, cutaneous, mucocutaneous, and visceral, with visceral leishmaniasis being fatal if left untreated.
View article: A Seed-Endophytic Bacillus safensis Strain With Antimicrobial Activity Has Genes for Novel Bacteriocin-Like Antimicrobial Peptides
A Seed-Endophytic Bacillus safensis Strain With Antimicrobial Activity Has Genes for Novel Bacteriocin-Like Antimicrobial Peptides Open
Bacteriocins are a highly diverse group of antimicrobial peptides that have been identified in a wide range of commensal and probiotic organisms, especially those resident in host microbiomes. Rising antibiotic resistance have fueled renew…
View article: Safety assessment of Streptococcus salivarius DB-B5 as a probiotic candidate for oral health
Safety assessment of Streptococcus salivarius DB-B5 as a probiotic candidate for oral health Open
Streptococcus salivarius DB-B5 was previously isolated from the supragingival plaque of a healthy female adult and selected for development as a probiotic candidate for oral health. Probiotics are an important emerging therapeutic method f…
View article: Synthetic Peptide Libraries Designed From a Minimal Alpha-Helical Domain of AS-48-Bacteriocin Homologs Exhibit Potent Antibacterial Activity
Synthetic Peptide Libraries Designed From a Minimal Alpha-Helical Domain of AS-48-Bacteriocin Homologs Exhibit Potent Antibacterial Activity Open
The circularized bacteriocin enterocin AS-48 produced by Enterococcus sp. exhibits antibacterial activity through membrane disruption. The membrane-penetrating activity of enterocin AS-48 has been attributed to a specific alpha-heli…
View article: Algorithmic assessment of missense mutation severity in the Von-Hippel Lindau protein
Algorithmic assessment of missense mutation severity in the Von-Hippel Lindau protein Open
Von Hippel-Lindau disease (VHL) is an autosomal dominant rare disease that causes the formation of angiogenic tumors. When functional, pVHL acts as an E3 ubiquitin ligase that negatively regulates hypoxia inducible factor (HIF). Genetic mu…
View article: Complete Genome Sequence of Streptococcus salivarius DB-B5, a Novel Probiotic Candidate Isolated from the Supragingival Plaque of a Healthy Female Subject
Complete Genome Sequence of Streptococcus salivarius DB-B5, a Novel Probiotic Candidate Isolated from the Supragingival Plaque of a Healthy Female Subject Open
Streptococcus salivarius DB-B5 was isolated from the supragingival plaque of a healthy female subject. The complete 2.3-Mb genome consists of one circular chromosome, two circular plasmids (including a megaplasmid), and one linear phage-li…
View article: Algorithmic Assessment of Missense Mutation Severity in the Von-Hippel Lindau Protein
Algorithmic Assessment of Missense Mutation Severity in the Von-Hippel Lindau Protein Open
Von Hippel-Lindau disease (VHL) is an autosomal dominant rare disease that causes the formation of angiogenic tumors. When functional, pVHL acts as an E3 ubiquitin ligase that negatively regulates hypoxia inducible factor (HIF). Genetic mu…
View article: Synthetic Antimicrobial Peptide Tuning Permits Membrane Disruption and Interpeptide Synergy
Synthetic Antimicrobial Peptide Tuning Permits Membrane Disruption and Interpeptide Synergy Open
The ribosomally produced antimicrobial peptides of bacteria (bacteriocins) represent an unexplored source of membrane-active antibiotics. We designed a library of linear peptides from a circular bacteriocin and show that pore-formation dyn…
View article: Novel antimicrobial peptide discovery using machine learning and biophysical selection of minimal bacteriocin domains
Novel antimicrobial peptide discovery using machine learning and biophysical selection of minimal bacteriocin domains Open
Bacteriocins, the ribosomally produced antimicrobial peptides of bacteria, represent an untapped source of promising antibiotic alternatives. However, bacteriocins display diverse mechanisms of action, a narrow spectrum of activity, and in…
View article: Discovery of genes encoding a Streptolysin S-like toxin biosynthetic cluster in a select highly pathogenic methicillin resistant<i>Staphylococcus aureus</i>JKD6159 strain
Discovery of genes encoding a Streptolysin S-like toxin biosynthetic cluster in a select highly pathogenic methicillin resistant<i>Staphylococcus aureus</i>JKD6159 strain Open
Background Staphylococcus aureus ( S. aureus ) is a major human pathogen owing to its arsenal of virulence factors, as well as its acquisition of multi-antibiotic resistance. Here we report the identification of a Streptolysin S (SLS) like…
View article: Novel antimicrobial peptide discovery using machine learning and biophysical selection of minimal bacteriocin domains
Novel antimicrobial peptide discovery using machine learning and biophysical selection of minimal bacteriocin domains Open
Bacteriocins are ribosomally produced antimicrobial peptides that represent an untapped source of promising antibiotic alternatives. However, inherent challenges in isolation and identification of natural bacteriocins in substantial yield …
View article: Rational design of syn-safencin, a novel linear antimicrobial peptide derived from the circular bacteriocin safencin AS-48
Rational design of syn-safencin, a novel linear antimicrobial peptide derived from the circular bacteriocin safencin AS-48 Open
View article: Using bacterial genomes and essential genes for the development of new antibiotics
Using bacterial genomes and essential genes for the development of new antibiotics Open