Francisco Navarro
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View article: Down-regulation of MIR-378A-3P expression associated with inflammation: The effects of restoring its levels
Down-regulation of MIR-378A-3P expression associated with inflammation: The effects of restoring its levels Open
Epigenetics has emerged as a modulator of inflammation-related diseases and changes in miRNA expression have been associated with regional location, inflamed mucosa and disease activity in Crohn´s disease (CD). We analyse here the differen…
View article: Characterization of Intestinal Mycobiome in Surgical Resections from Inflammatory Bowel Disease Patients: A Deeper Analysis in Complicated Crohn’s Disease Phenotypes
Characterization of Intestinal Mycobiome in Surgical Resections from Inflammatory Bowel Disease Patients: A Deeper Analysis in Complicated Crohn’s Disease Phenotypes Open
Background Inflammatory bowel disease (IBD), which encompasses ulcerative colitis (UC) and Crohn’s disease (CD), is a chronic condition characterized by recurrent intestinal inflammation and complications. Despite extensive research on bac…
View article: P2X7 Receptor Regulates Collagen Expression in Human Intestinal Fibroblasts: Relevance in Intestinal Fibrosis
P2X7 Receptor Regulates Collagen Expression in Human Intestinal Fibroblasts: Relevance in Intestinal Fibrosis Open
Intestinal fibrosis is a common complication that affects more than 50% of Crohn´s Disease (CD) patients. There is no pharmacological treatment against this complication, with surgery being the only option. Due to the unknown role of P2X7 …
View article: Minimally Invasive Abdominal Repair of a Giant Paraesophageal Hiatal Hernia with Occupation of the Right Thorax in a 53-Year-Old Man
Minimally Invasive Abdominal Repair of a Giant Paraesophageal Hiatal Hernia with Occupation of the Right Thorax in a 53-Year-Old Man Open
Paraesophageal giant hiatal hernia is a rare condition associated with serious complications if not treated surgically. There are no reports of the minimally invasive abdominal repair of a giant hiatal hernia of the stomach almost entirely…
View article: Current trends and outcomes of non-elective neurosurgical care in Central Europe during the second year of the COVID-19 pandemic
Current trends and outcomes of non-elective neurosurgical care in Central Europe during the second year of the COVID-19 pandemic Open
View article: LA LLEGADA DE LA RADIOFONÍA A CANARIAS (1924-1936)
LA LLEGADA DE LA RADIOFONÍA A CANARIAS (1924-1936) Open
In this work we revise the evolution of the first period of radio broadcasting in the Canary Islands, from the first emitting stations to the beginning of the Civil War. It also comprises the analysis of the main regulatory milestones, as …
View article: IFNγ-Treated Macrophages Induce EMT through the WNT Pathway: Relevance in Crohn’s Disease
IFNγ-Treated Macrophages Induce EMT through the WNT Pathway: Relevance in Crohn’s Disease Open
Background: Fibrosis is a common complication of Crohn’s disease (CD) in which macrophages play a central role. Epithelial-mesenchymal transition (EMT) and the WNT pathway have been associated with fibrosis. We aim to analyse the relevance…
View article: IFNγ-treated macrophages induce EMT through the WNT pathway: relevance in Crohn´s disease
IFNγ-treated macrophages induce EMT through the WNT pathway: relevance in Crohn´s disease Open
Supplementary material of the article
View article: SUCNR1 Mediates the Priming Step of the Inflammasome in Intestinal Epithelial Cells: Relevance in Ulcerative Colitis
SUCNR1 Mediates the Priming Step of the Inflammasome in Intestinal Epithelial Cells: Relevance in Ulcerative Colitis Open
Intestinal epithelial cells (IECs) constitute a defensive physical barrier in mucosal tissues and their disruption is involved in the etiopathogenesis of several inflammatory pathologies, such as Ulcerative Colitis (UC). Recently, the succ…
View article: Research in surgery: The adversities that every surgeon should know and face
Research in surgery: The adversities that every surgeon should know and face Open
Introduction: Clinical and experimental research in medicine has been the main path to most of advances in diagnosis and therapy throughout the history, with remarkable surgeons as researchers. To develop good quality research in surgery i…
View article: P718 Characterization of microbiota and metabolomic profile in human colonic surgical resections of UC patients
P718 Characterization of microbiota and metabolomic profile in human colonic surgical resections of UC patients Open
Background Ulcerative colitis (UC) is characterized by a diffuse, continuous, and chronic inflammation of mucosa and submucosa layers in the colon whose etiology is still unknown. Intestinal microbiota dysbiosis and alterations in the meta…
View article: P088 Metabolomic analysis reveals differences among UC and non-IBD human colonic resections: role of GPCRs
P088 Metabolomic analysis reveals differences among UC and non-IBD human colonic resections: role of GPCRs Open
Background Metabolomics is a recent technique that has bounced into Inflammatory Bowel Diseases (IBD) due to its capacity to elucidate specific metabolites involved in the pathology and changes in the metabolomic profile have been detected…
View article: Selenium Supplementation Influences Mice Testicular Selenoproteins Driven By Gut Microbiota
Selenium Supplementation Influences Mice Testicular Selenoproteins Driven By Gut Microbiota Open
Selenium is a well-known essential element with important roles in human reproductive health mainly due to its antioxidant character. This study aimed to investigate the potential role of selenoproteins on the gut microbiota-reproductive h…
View article: Trends and outcomes for non-elective neurosurgical procedures in Central Europe during the COVID-19 pandemic
Trends and outcomes for non-elective neurosurgical procedures in Central Europe during the COVID-19 pandemic Open
View article: Acute abdomen due to pancreatic pseudocyst with splenic extension and rupture
Acute abdomen due to pancreatic pseudocyst with splenic extension and rupture Open
Pancreatic pseudocyst is a common complication of acute and chronic pancreatitis. However, spleen involvement in pancreatitis is rare. We present a patient with a pancreatic tail pseudocyst with splenic extension and rupture. Due to initia…
View article: Succinate Activates EMT in Intestinal Epithelial Cells through SUCNR1: A Novel Protagonist in Fistula Development
Succinate Activates EMT in Intestinal Epithelial Cells through SUCNR1: A Novel Protagonist in Fistula Development Open
The pathogenesis of Crohn’s disease-associated fibrostenosis and fistulas imply the epithelial-to-mesenchymal transition (EMT) process. As succinate and its receptor (SUCNR1) are involved in intestinal inflammation and fibrosis, we investi…
View article: Diminished Vitamin D Receptor Protein Levels in Crohn’s Disease Fibroblasts: Effects of Vitamin D
Diminished Vitamin D Receptor Protein Levels in Crohn’s Disease Fibroblasts: Effects of Vitamin D Open
Vitamin D (VD) deficiency has been associated to Crohn’s disease (CD) pathogenesis, and the exogenous administration of VD improves the course of the disease, but the mechanistic basis of these observations remains unknown. Vitamin D recep…
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Table of Contents Open
View article: Autophagy Stimulation as a Potential Strategy Against Intestinal Fibrosis
Autophagy Stimulation as a Potential Strategy Against Intestinal Fibrosis Open
We recently observed reduced autophagy in Crohn’s disease patients and an anti-inflammatory effect of autophagy stimulation in murine colitis, but both anti- and pro-fibrotic effects are associated with autophagy stimulation in different t…
View article: Succinate receptor mediates intestinal inflammation and fibrosis
Succinate receptor mediates intestinal inflammation and fibrosis Open