Francisco S. Domingues
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View article: Evaluating the Antiviral Activity of Termin-8 and Finio Against a Surrogate ASFV-like Algal Virus
Evaluating the Antiviral Activity of Termin-8 and Finio Against a Surrogate ASFV-like Algal Virus Open
The objective of this study was to evaluate the time-course of incubation for the potential preventative mitigation of megaviruses using Termin-8 (a formaldehyde-based product) and Finio (non-formaldehyde solution) from Anitox. Emiliania h…
View article: Haplomics: A Snakemake pipeline for haplotype-based association analysis in multi-omics studies
Haplomics: A Snakemake pipeline for haplotype-based association analysis in multi-omics studies Open
Summary Genome-wide association studies (GWAS) generated thousands of loci associated with complex traits and diseases. However, to characterize of the pleiotropic, molecular and population genetic bounds of uncovered loci, investigations …
View article: Evaluating the antiviral activity of Termin-8 and Finio against a surrogate ASFV-like algal virus
Evaluating the antiviral activity of Termin-8 and Finio against a surrogate ASFV-like algal virus Open
Introduction Anitox has developed and markets Termin-8 (a formaldehyde-based product) and Finio (non-formaldehyde solution) for the control microbial contamination in feed. To date, both Finio and Termin-8 have not been tested for their po…
View article: PSII-15 Evaluation of a blend of phytochemicals and carboxylic acid on complete feed when inoculated with porcine epidemic diarrhea virus, porcine reproductive and respiratory syndrome virus, and SVA virus 1
PSII-15 Evaluation of a blend of phytochemicals and carboxylic acid on complete feed when inoculated with porcine epidemic diarrhea virus, porcine reproductive and respiratory syndrome virus, and SVA virus 1 Open
Chemical mitigants have been found to decrease virus concentrations in swine feed. Continued research is needed to identify the appropriate inclusion levels and application time for different viruses in this matrix. The objective was to ev…
View article: PSI-15 Evaluation of a feed sanitizer in sow diets
PSI-15 Evaluation of a feed sanitizer in sow diets Open
Reduced microbial and pathogen content in feed is hypothesized to improve performance of sows and their nursing litters. The objectives of this study were to evaluate the effects of a formaldehyde, propionic acid, and terpene-based feed sa…
View article: PSII-16 Evaluation of formaldehyde on complete feed when inoculated with porcine epidemic diarrhea virus, porcine reproductive and respiratory syndrome virus, and Seneca Valley virus 1
PSII-16 Evaluation of formaldehyde on complete feed when inoculated with porcine epidemic diarrhea virus, porcine reproductive and respiratory syndrome virus, and Seneca Valley virus 1 Open
Chemical mitigants have been found to decrease virus concentrations in feed. Continued research is needed to identify the appropriate inclusion levels and application time for different viruses in this matrix. Therefore, the objective was …
View article: Extensive modulation of the circulating blood proteome by hormonal contraceptive use across two population studies
Extensive modulation of the circulating blood proteome by hormonal contraceptive use across two population studies Open
View article: Cohort Profile: the Cooperative Health Research in South Tyrol study
Cohort Profile: the Cooperative Health Research in South Tyrol study Open
Key Features
View article: Characterization of metabolically healthy and unhealthy obesity through circulating proteins and metabolites
Characterization of metabolically healthy and unhealthy obesity through circulating proteins and metabolites Open
Background Individuals affected by obesity present different health trajectories and do not suffer from cardiometabolic complications all in the same way. There is a need to better understand obesity subtypes and to develop approaches for …
View article: Clinical and Metabolic Signatures of FAM47E–SHROOM3 Haplotypes in a General Population Sample
Clinical and Metabolic Signatures of FAM47E–SHROOM3 Haplotypes in a General Population Sample Open
The genetic variability of the FAM47E-SHROOM3 locus indicates the existence of population subgroups with distinct biomarker profiles.
View article: Metabolite and protein associations with general health in the population-based CHRIS study
Metabolite and protein associations with general health in the population-based CHRIS study Open
Identifying biomarkers able to discriminate individuals on different health trajectories is crucial to understand the molecular basis of age-related morbidity. We investigated multi-omics signatures of general health and organ-specific mor…
View article: Identifying Metabolomic and Proteomic Biomarkers for Age-Related Morbidity in a Population-Based Cohort - the Cooperative Health Research in South Tyrol (CHRIS) study
Identifying Metabolomic and Proteomic Biomarkers for Age-Related Morbidity in a Population-Based Cohort - the Cooperative Health Research in South Tyrol (CHRIS) study Open
Identifying biomarkers able to discriminate individuals on different health trajectories is crucial to understand the molecular basis of age-related morbidity. We investigated multi-omics signatures of general health and organ-specific mor…
View article: PSI-4 Evaluation of chemical mitigants when soybean meal was inoculated with porcine epidemic diarrhea virus, porcine reproductive and respiratory virus, and Seneca Valley virus 1
PSI-4 Evaluation of chemical mitigants when soybean meal was inoculated with porcine epidemic diarrhea virus, porcine reproductive and respiratory virus, and Seneca Valley virus 1 Open
Chemical mitigants have been found to decrease virus concentrations in feed and ingredient matrices. Continued research is needed to identify the appropriate inclusion levels and application time for different viruses in these matrices. Th…
View article: Phenotypic spectrum of<i>FAM47E</i>-<i>SHROOM3</i>haplotype composition in a general population sample
Phenotypic spectrum of<i>FAM47E</i>-<i>SHROOM3</i>haplotype composition in a general population sample Open
Genome-wide association studies identified a locus on chromosome 4q21.1, spanning the FAM47E , STBD1 , CCDC158 , and SHROOM3 genes, as associated with kidney function markers. Functional studies implicated SHROOM3 , encoding an actin-bindi…
View article: Intracellular delivery of Parkin-RING0-based fragments corrects Parkin-induced mitochondrial dysfunction through interaction with SLP-2
Intracellular delivery of Parkin-RING0-based fragments corrects Parkin-induced mitochondrial dysfunction through interaction with SLP-2 Open
Background Loss-of-function mutations in the PRKN gene, encoding Parkin, are the most common cause of autosomal recessive Parkinson’s disease (PD). We have previously identified mitoch ondrial Stomatin-like protein 2 (SLP-2), which functio…
View article: Evaluation of formaldehyde when complete feed and soybean meal were inoculated with porcine epidemic diarrhea virus, porcine reproductive and respiratory syndrome virus, and Seneca Valley virus 1
Evaluation of formaldehyde when complete feed and soybean meal were inoculated with porcine epidemic diarrhea virus, porcine reproductive and respiratory syndrome virus, and Seneca Valley virus 1 Open
Formaldehyde has been found to decrease virus concentrations in feed and ingredient matrices. Continued research is needed to identify the appropriate inclusion levels and application time for different viruses in these matrices. The objec…
View article: Pervasive Influence of Hormonal Contraceptives on the Human Plasma Proteome in a Broad Population Study
Pervasive Influence of Hormonal Contraceptives on the Human Plasma Proteome in a Broad Population Study Open
Background Plasma proteomics offers new avenues to explore non-genetic associations, such as biomarkers for lifestyle and environmental exposure in population studies. To date, most proteomic investigations in population studies have utili…
View article: Association of dietary proteins with serum creatinine and estimated glomerular filtration rate in a general population sample: the CHRIS study
Association of dietary proteins with serum creatinine and estimated glomerular filtration rate in a general population sample: the CHRIS study Open
Background Diet is known to affect kidney function. However, population-based studies provide contrasting evidence, resulting in a poor understanding of the effect of proteins from specific foods on kidney health. Methods We analyzed the e…
View article: Impacto da Intervenção com Infliximabe no Conteúdo Tecidual de E-Caderina e Claudina-3 no Epitélio Cólico em Modelo Experimental de Colite de Exclusão
Impacto da Intervenção com Infliximabe no Conteúdo Tecidual de E-Caderina e Claudina-3 no Epitélio Cólico em Modelo Experimental de Colite de Exclusão Open
Objetivo Verificar se a aplicação de infliximabe modifica o conteúdo tecidual das proteínas E-caderina e claudina-3 no epitélio cólico de ratos desprovidos de trânsito intestinal.
View article: Genetic and Metabolic Determinants of Atrial Fibrillation in a General Population Sample: The CHRIS Study
Genetic and Metabolic Determinants of Atrial Fibrillation in a General Population Sample: The CHRIS Study Open
Atrial fibrillation (AF) is a supraventricular arrhythmia deriving from uncoordinated electrical activation with considerable associated morbidity and mortality. To expand the limited understanding of AF biological mechanisms, we performed…
View article: Prospective epidemiological, molecular, and genetic characterization of a novel coronavirus disease in the Val Venosta/Vinschgau: the CHRIS COVID-19 study protocol
Prospective epidemiological, molecular, and genetic characterization of a novel coronavirus disease in the Val Venosta/Vinschgau: the CHRIS COVID-19 study protocol Open
The COVID-19 pandemic has been threatening the healthcare and socioeconomic systems of entire nations. While population-based surveys to assess the distribution of SARS-CoV-2 infection have become a priority, pre-existing longitudinal stud…
View article: Exome-wide association study of levodopa-induced dyskinesia in Parkinson’s disease
Exome-wide association study of levodopa-induced dyskinesia in Parkinson’s disease Open
View article: Prospective epidemiological, molecular, and genetic characterization of a novel coronavirus disease in the Val Venosta/Vinschgau: the CHRIS COVID-19 study protocol
Prospective epidemiological, molecular, and genetic characterization of a novel coronavirus disease in the Val Venosta/Vinschgau: the CHRIS COVID-19 study protocol Open
The COVID-19 pandemic has been threatening the healthcare and socioeconomic systems of entire nations. While population-based surveys to assess the distribution of SARS-CoV-2 infection have become a priority, pre-existing longitudinal stud…
View article: Genome-Wide Association Study Identifies Novel Loci Associated with Circulating Phospho- and Sphingolipid Concentrations
Genome-Wide Association Study Identifies Novel Loci Associated with Circulating Phospho- and Sphingolipid Concentrations Open
Phospho- and sphingolipids are crucial cellular and intracellular compounds. These lipids are required for active transport, a number of enzymatic processes, membrane formation, and cell signalling. Disruption of their metabolism leads to …
View article: Peptidomimetic Escape Mechanisms Arise via Genetic Diversity in the Ligand-Binding Site of the Hepatitis C Virus NS3/4A Serine Protease
Peptidomimetic Escape Mechanisms Arise via Genetic Diversity in the Ligand-Binding Site of the Hepatitis C Virus NS3/4A Serine Protease Open
It is a challenge to develop direct-acting antiviral agents (DAAs) that target the NS3/4A protease of hepatitis C virus (HCV) because resistant variants develop. Ketoamide compounds, designed to mimic the natural protease substrate, have b…
View article: Ketoamide Resistance and Hepatitis C Virus Fitness in Val55 Variants of the NS3 Serine Protease
Ketoamide Resistance and Hepatitis C Virus Fitness in Val55 Variants of the NS3 Serine Protease Open
Drug-resistant viral variants are a major issue in the use of direct-acting antiviral agents in chronic hepatitis C. Ketoamides are potent inhibitors of the NS3 protease, with V55A identified as mutation associated with resistance to bocep…
View article: Near-Neighbor Interactions in the NS3-4A Protease of HCV Impact Replicative Fitness of Drug-Resistant Viral Variants
Near-Neighbor Interactions in the NS3-4A Protease of HCV Impact Replicative Fitness of Drug-Resistant Viral Variants Open
View article: Parkin Interacts with Apoptosis-Inducing Factor and Interferes with Its Translocation to the Nucleus in Neuronal Cells
Parkin Interacts with Apoptosis-Inducing Factor and Interferes with Its Translocation to the Nucleus in Neuronal Cells Open
Mutations in the PRKN gene (encoding parkin) have been linked to the most frequent known cause of recessive Parkinson’s disease (PD), and parkin dysfunction represents a risk factor for sporadic PD. Parkin is widely neuroprotective through…
View article: Compound heterozygous SZT2 mutations in two siblings with early-onset epilepsy, intellectual disability and macrocephaly
Compound heterozygous SZT2 mutations in two siblings with early-onset epilepsy, intellectual disability and macrocephaly Open
Variable phenotypic expressivity is observed for this condition, while the location and type of mutations in SZT2 also has a potential impact on epilepsy severity. These findings extend our knowledge of epileptogenic conditions related to …
View article: Comparative assessment of different familial aggregation methods in the context of large and unstructured pedigrees
Comparative assessment of different familial aggregation methods in the context of large and unstructured pedigrees Open
Motivation Familial aggregation analysis is an important early step for characterizing the genetic determinants of phenotypes in epidemiological studies. To facilitate this analysis, a collection of methods to detect familial aggregation i…