Francisco Vasques‐Nóvoa
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View article: GLP‐1 Receptor Agonists for the Prevention of New‐Onset Heart Failure: A Systematic Review and Meta‐Analysis of Placebo‐Controlled Randomized Clinical Trials
GLP‐1 Receptor Agonists for the Prevention of New‐Onset Heart Failure: A Systematic Review and Meta‐Analysis of Placebo‐Controlled Randomized Clinical Trials Open
Introduction Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RA) improve outcomes in heart failure (HF) with preserved ejection fraction. Whether GLP‐1 RA prevent new‐onset HF in Type 2 diabetes or obesity requires further investigation. …
View article: Effects of <scp>SGLT2</scp> inhibitors across the spectrum of albuminuria in cardiovascular–kidney–metabolic conditions: A pooled analysis of randomised trials
Effects of <span>SGLT2</span> inhibitors across the spectrum of albuminuria in cardiovascular–kidney–metabolic conditions: A pooled analysis of randomised trials Open
Background Albuminuria is associated with an increased risk of cardiovascular and kidney events. Sodium glucose co‐transporter 2 inhibitors ( SGLT2i ) reduce albuminuria and improve kidney outcomes in patients with albuminuric chronic kidn…
View article: Sodium–glucose co‐transporter 2 inhibitors in severe estimated glomerular filtration rate deterioration across cardiovascular‐kidney‐ metabolic conditions: A pooled analysis of randomized trials
Sodium–glucose co‐transporter 2 inhibitors in severe estimated glomerular filtration rate deterioration across cardiovascular‐kidney‐ metabolic conditions: A pooled analysis of randomized trials Open
Aims The efficacy of sodium–glucose co‐transporter 2 inhibitors (SGLT2i) among patients with cardiovascular‐kidney‐metabolic (CKM) conditions who experience severe estimated glomerular filtration rate (eGFR) deterioration during follow‐up …
View article: The CCL2-driven monocyte-macrophage axis in progressive fibrosing hypersensitivity pneumonitis
The CCL2-driven monocyte-macrophage axis in progressive fibrosing hypersensitivity pneumonitis Open
Background Hypersensitivity pneumonitis is characterized by immune dysregulation that often leads to irreversible lung tissue scarring. While elevated monocytes play a key role in idiopathic pulmonary fibrosis, their contribution in progre…
View article: SGLT2 inhibitor with and without ALDosterone AntagonIst for heart failure with preserved ejection fraction: Design paper
SGLT2 inhibitor with and without ALDosterone AntagonIst for heart failure with preserved ejection fraction: Design paper Open
Background Sodium glucose co‐transporter 2 inhibitors (SGLT2i) and mineralocorticoid receptor antagonists (MRA) reduce heart failure (HF) events in patients with heart failure and mildly reduced or preserved ejection fraction (HFmr/pEF). T…
View article: Device-based Strategies for Monitoring Congestion and Guideline-directed Therapy in Heart Failure: The Who, When and How of Personalised Care
Device-based Strategies for Monitoring Congestion and Guideline-directed Therapy in Heart Failure: The Who, When and How of Personalised Care Open
Despite therapeutic and technological advances, the prognosis for patients with heart failure (HF) remains poor. One reason for this poor prognosis lies in the limited usage of disease-modifying therapies, such as β-blockers, renin–angiote…
View article: Low blood pressure and the effect of empagliflozin in acute heart failure: An <scp>EMPULSE</scp> analysis
Low blood pressure and the effect of empagliflozin in acute heart failure: An <span>EMPULSE</span> analysis Open
Aims Empagliflozin improves outcomes in acute heart failure (AHF). Patients with AHF and low blood pressure (BP) have poor prognosis. Whether empagliflozin is effective and safe in patients with AHF and low BP is currently unknown. The aim…
View article: Anaemia, erythrocytosis, and empagliflozin in heart failure with preserved ejection fraction: the EMPEROR-Preserved trial
Anaemia, erythrocytosis, and empagliflozin in heart failure with preserved ejection fraction: the EMPEROR-Preserved trial Open
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View article: Ferritin, inflammation, and iron deficiency in acute heart failure: evidence from the EDIFICA cohort
Ferritin, inflammation, and iron deficiency in acute heart failure: evidence from the EDIFICA cohort Open
Background Ferritin is commonly used to evaluate iron stores and guide therapeutic decisions regarding intravenous iron supplementation. However, in the context of AHF, inflammation-driven upregulation of ferritin might disrupt its correla…
View article: Enhancing Urological Cancer Treatment: Leveraging Vasodilator Synergistic Potential with 5-FU for Improved Therapeutic Outcomes
Enhancing Urological Cancer Treatment: Leveraging Vasodilator Synergistic Potential with 5-FU for Improved Therapeutic Outcomes Open
Backgroud: This study investigates the potential of vasodilator drugs as additive therapy in the treatment of urological cancers, particularly in combination with the antineoplastic agent 5-fluorouracil (5-FU). Methods: The study evaluated…
View article: Inhibition of circulating dipeptidyl-peptidase 3 by procizumab in experimental septic shock reduces catecholamine exposure and myocardial injury
Inhibition of circulating dipeptidyl-peptidase 3 by procizumab in experimental septic shock reduces catecholamine exposure and myocardial injury Open
Background Dipeptidyl peptidase 3 (DPP3) is a ubiquitous cytosolic enzyme released into the bloodstream after tissue injury, that can degrade angiotensin II. High concentrations of circulating DPP3 (cDPP3) have been associated with worse o…
View article: Empagliflozin and risk of lower respiratory tract infection in heart failure with mildly reduced and preserved ejection fraction: An <scp>EMPEROR‐Preserved</scp> analysis
Empagliflozin and risk of lower respiratory tract infection in heart failure with mildly reduced and preserved ejection fraction: An <span>EMPEROR‐Preserved</span> analysis Open
Aims Lower respiratory tract infections (LRTI) are common worldwide. Patients with heart failure and mildly reduced or preserved ejection fraction (HFmrEF/HFpEF) have a high risk of developing LRTI. Prior studies were able to show that sod…
View article: Polymorphisms and haplotypes of <i>TOLLIP</i> and <i>MUC5B</i> are associated with susceptibility and survival in patients with fibrotic hypersensitivity pneumonitis
Polymorphisms and haplotypes of <i>TOLLIP</i> and <i>MUC5B</i> are associated with susceptibility and survival in patients with fibrotic hypersensitivity pneumonitis Open
These findings suggest that TOLLIP and MUC5B variants and haplotypes may serve as valuable tools for risk assessment and prognosis in fibrotic hypersensitivity pneumonitis, potentially contributing to its patient stratification, and offer …
View article: Acute and chronic effects of levosimendan in the ZSF1 obese rat model of heart failure with preserved ejection fraction
Acute and chronic effects of levosimendan in the ZSF1 obese rat model of heart failure with preserved ejection fraction Open
Heart failure with preserved ejection fraction (HFpEF) is a syndrome characterized by impaired cardiovascular reserve in which therapeutic options are scarce. Our aim was to evaluate the inodilator levosimendan in the ZSF1 obese rat model …
View article: Standardized approach for extubation during extracorporeal membrane oxygenation in severe acute respiratory distress syndrome: a prospective observational study
Standardized approach for extubation during extracorporeal membrane oxygenation in severe acute respiratory distress syndrome: a prospective observational study Open
Background Extubation during extracorporeal oxygenation (ECMO) in severe acute respiratory distress syndrome (ARDS) has not been well studied. Despite the potential benefits of this strategy, weaning from ECMO before liberation from invasi…
View article: Corrigendum: Consistent long-term therapeutic efficacy of human umbilical cord matrix-derived mesenchymal stromal cells after myocardial infarction despite individual differences and transient engraftment
Corrigendum: Consistent long-term therapeutic efficacy of human umbilical cord matrix-derived mesenchymal stromal cells after myocardial infarction despite individual differences and transient engraftment Open
[This corrects the article DOI: 10.3389/fcell.2021.624601.].
View article: Myocardial RNA Sequencing Reveals New Potential Therapeutic Targets in Heart Failure with Preserved Ejection Fraction
Myocardial RNA Sequencing Reveals New Potential Therapeutic Targets in Heart Failure with Preserved Ejection Fraction Open
Heart failure with preserved ejection fraction (HFpEF) represents a global health challenge, with limited therapies proven to enhance patient outcomes. This makes the elucidation of disease mechanisms and the identification of novel potent…
View article: Glucagon-Like Peptide-1 Receptor Agonists Across the Spectrum of Heart Failure
Glucagon-Like Peptide-1 Receptor Agonists Across the Spectrum of Heart Failure Open
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have been used to reduce body weight in overweight or people with obesity and to improve glycemic control and cardiovascular outcomes among people with type 2 diabetes (T2D) and a high …
View article: Effects of Triiodothyronine Treatment in an Animal Model of Heart Failure with Preserved Ejection Fraction
Effects of Triiodothyronine Treatment in an Animal Model of Heart Failure with Preserved Ejection Fraction Open
Background: Low levels of triiodothyronine (T3) are common in patients with heart failure (HF). Our aim was to evaluate the effects of supplementation with low and replacement doses of T3 in an animal model of HF with preserved ejection fr…
View article: The Effect of the Stress Induced by Hydrogen Peroxide and Corticosterone on Tryptophan Metabolism, Using Human Neuroblastoma Cell Line (SH-SY5Y)
The Effect of the Stress Induced by Hydrogen Peroxide and Corticosterone on Tryptophan Metabolism, Using Human Neuroblastoma Cell Line (SH-SY5Y) Open
L-tryptophan (L-Trp) is an important amino acid in several physiological mechanisms, being metabolized into two important pathways: the kynurenine and the serotonin (5-HT) pathways. It is important in processes such as mood and stress resp…
View article: In Vitro Drug Repurposing: Focus on Vasodilators
In Vitro Drug Repurposing: Focus on Vasodilators Open
Drug repurposing aims to identify new therapeutic uses for drugs that have already been approved for other conditions. This approach can save time and resources compared to traditional drug development, as the safety and efficacy of the re…
View article: Glucagon‐like peptide 1 receptor agonists in patients with type 2 diabetes with and without chronic heart failure: A meta‐analysis of randomized placebo‐controlled outcome trials
Glucagon‐like peptide 1 receptor agonists in patients with type 2 diabetes with and without chronic heart failure: A meta‐analysis of randomized placebo‐controlled outcome trials Open
Aim Glucagon‐like peptide 1 receptor agonists (GLP1‐RA) reduce atherosclerotic events in patients with type 2 diabetes (T2D) and a high cardiovascular risk. The effect of GLP1‐RA to reduce heart failure (HF) has been inconsistent across T2…
View article: Door-to-furosemide time and clinical outcomes in acute heart failure
Door-to-furosemide time and clinical outcomes in acute heart failure Open
Background and importance Acute heart failure (AHF) is one of the main causes of unplanned hospitalization in patients >65 years of age and is associated with adverse outcomes in this population. Observational studies suggest that intraven…
View article: Supplementary Material for: Clinical and Pathophysiologic Insights of Free triiodothyronine/Free thyroxine Ratio in Patients with Heart Failure with Preserved Ejection Fraction: Data from the NETDiamond Cohort
Supplementary Material for: Clinical and Pathophysiologic Insights of Free triiodothyronine/Free thyroxine Ratio in Patients with Heart Failure with Preserved Ejection Fraction: Data from the NETDiamond Cohort Open
Background: Thyroid dysfunction is common in patients with heart failure (HF). Impaired conversion of free T4 (FT4) into free T3 (FT3) is thought to occur in these patients, decreasing the availability of FT3 and contributing to HF progres…