Franck C. Chatelain
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View article: Two pore domain THIK2 channel is involved in acute and chronic pain signal regulation
Two pore domain THIK2 channel is involved in acute and chronic pain signal regulation Open
Two-pore domain potassium channels (K 2P ) regulate neuronal excitability by acting as hyperpolarizing leak channels. Among them, THIK2 remain poorly characterized. Although no study has yet clearly linked them to excitability or pain, the…
View article: Mechanistic basis of the dynamic response of TWIK1 ionic selectivity to pH
Mechanistic basis of the dynamic response of TWIK1 ionic selectivity to pH Open
Highly selective for K + at neutral pH, the TWIK1 channel becomes permeable to Na + upon acidification. Using molecular dynamics simulations, we identify a network of residues involved in this unique property. Between the open and closed s…
View article: Mechanistic basis of the dynamic response of TWIK1 ionic selectivity to pH
Mechanistic basis of the dynamic response of TWIK1 ionic selectivity to pH Open
At neutral pH, the TWIK1 channel is highly selective for K + . When exposed to acidification, it becomes permeable to Na + . This change occurs within minutes and is reversible. By combining pKa calculations, molecular dynamics (MD) simula…
View article: Corrigendum: Convergence of Multiple Stimuli to a Single Gate in TREK1 and TRAAK Potassium Channels
Corrigendum: Convergence of Multiple Stimuli to a Single Gate in TREK1 and TRAAK Potassium Channels Open
[This corrects the article DOI: 10.3389/fphar.2021.755826.].
View article: Heteromerization of alkaline-sensitive two-pore domain potassium channels
Heteromerization of alkaline-sensitive two-pore domain potassium channels Open
Two-pore domain (K 2P ) potassium channels are active as dimers. They produce inhibitory currents regulated by a variety of stimuli. Among them, TALK1, TALK2 and TASK2 form a subfamily of structurally related K 2P channels stimulated by ex…
View article: A standardised hERG phenotyping pipeline to evaluate <i>KCNH2</i> genetic variant pathogenicity
A standardised hERG phenotyping pipeline to evaluate <i>KCNH2</i> genetic variant pathogenicity Open
Background and aims Mutations in KCNH2 cause long or short QT syndromes (LQTS or SQTS) predisposing to life‐threatening arrhythmias. Over 1000 hERG variants have been described by clinicians, but most remain to be characterised. The object…
View article: Piezo1 and Piezo2 foster mechanical gating of K2P channels
Piezo1 and Piezo2 foster mechanical gating of K2P channels Open
Mechanoelectrical transduction is mediated by the opening of different types of force-sensitive ion channels, including Piezo1/2 and the TREK/TRAAK K2P channels. Piezo1 curves the membrane locally into an inverted dome that reversibly flat…
View article: Physiological roles of heteromerization: focus on the two‐pore domain potassium channels
Physiological roles of heteromerization: focus on the two‐pore domain potassium channels Open
Potassium channels form the largest family of ion channels with more than 80 members involved in cell excitability and signalling. Most of them exist as homomeric channels, whereas specific conditions are required to obtain heteromeric cha…
View article: Physiological roles of heteromerization: focus on the two-pore domain potassium channels
Physiological roles of heteromerization: focus on the two-pore domain potassium channels Open
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View article: Selectivity filter instability dominates the low intrinsic activity of the TWIK-1 K2P K<sup>+</sup> Channel
Selectivity filter instability dominates the low intrinsic activity of the TWIK-1 K2P K<sup>+</sup> Channel Open
Two-pore domain (K2P) K + channels have many important physiological functions. However, the functional properties of the TWIK-1 (K2P1.1/ KCNK1 ) K2P channel remain poorly characterized because heterologous expression of this ion channel y…
View article: Antagonistic Effect of a Cytoplasmic Domain on the Basal Activity of Polymodal Potassium Channels
Antagonistic Effect of a Cytoplasmic Domain on the Basal Activity of Polymodal Potassium Channels Open
TREK/TRAAK channels are polymodal K+ channels that convert very diverse stimuli, including bioactive lipids, mechanical stretch and temperature, into electrical signals. The nature of the structural changes that regulate their activity rem…
View article: Development of\nthe First Two-Pore Domain Potassium\nChannel TWIK-Related K<sup>+</sup> Channel 1‑Selective Agonist\nPossessing in Vivo Antinociceptive Activity
Development of\nthe First Two-Pore Domain Potassium\nChannel TWIK-Related K<sup>+</sup> Channel 1‑Selective Agonist\nPossessing in Vivo Antinociceptive Activity Open
The\nTWIK-related K+ channel, TREK-1, has recently emerged\nas an attractive therapeutic target for the development of a novel\nclass of analgesic drugs, suggesting that activation of TREK-1 could\nresult in pain inhibition. Here, we repor…
View article: In cellulo phosphorylation induces pharmacological reprogramming of maurocalcin, a cell-penetrating venom peptide
In cellulo phosphorylation induces pharmacological reprogramming of maurocalcin, a cell-penetrating venom peptide Open
Significance Animal toxin peptides typically exhibit high affinity and selectivity for specific subclasses of cell receptors that account for their activity. Posttranslational modifications of toxin sequences may occur in the venom gland m…