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View article: Dynamic DNA methylation changes during colorectal oncogenesis with insights from adenoma stages
Dynamic DNA methylation changes during colorectal oncogenesis with insights from adenoma stages Open
The dynamics of colorectal epigenetics within the adenoma stages of oncogenesis remain undocumented. In this study, we investigated DNA methylation dynamics in colorectal cancer oncogenesis from non-tumor colon tissue to low-grade, high-gr…
View article: POS0913 PRESENCE OF MAIT CELLS IN SYNOVIAL TISSUE OF PATIENTS WITH AXIAL SPONDYLOARTHRITIS: A COMPARATIVE STUDY
POS0913 PRESENCE OF MAIT CELLS IN SYNOVIAL TISSUE OF PATIENTS WITH AXIAL SPONDYLOARTHRITIS: A COMPARATIVE STUDY Open
View article: Deciphering human endogenous retrovirus expression in colorectal cancers: exploratory analysis regarding prognostic value in liver metastases
Deciphering human endogenous retrovirus expression in colorectal cancers: exploratory analysis regarding prognostic value in liver metastases Open
View article: Characterization and clinical outcomes of rare biliary adenosquamous carcinoma
Characterization and clinical outcomes of rare biliary adenosquamous carcinoma Open
BASC is a rare disease with an increased incidence, highlighting the diagnostic challenges. BASC population was associated with a poor prognostic and limited therapeutic response. Further molecular investigations should be performed to inv…
View article: Liver metastases of colorectal cancer contain different subsets of tissue-resident memory CD8 T cells correlated with a distinct risk of relapse following surgery
Liver metastases of colorectal cancer contain different subsets of tissue-resident memory CD8 T cells correlated with a distinct risk of relapse following surgery Open
Tissue-resident memory (TRM) T cells have emerged as key players in cancer immunosurveillance, and their presence has been linked to a favorable clinical outcome in solid cancer patients. Liver metastases exhibit a highly immuno…
View article: Deep Multiple Instance Learning Model to Predict Outcome of Pancreatic Cancer Following Surgery
Deep Multiple Instance Learning Model to Predict Outcome of Pancreatic Cancer Following Surgery Open
Background/Objectives: Pancreatic ductal adenocarcinoma (PDAC) is a cancer with very poor prognosis despite early surgical management. To date, only clinical variables are used to predict outcome for decision-making about adjuvant therapy.…
View article: 9P CXCR6+PD-1- Tissue resident memory T cells are associated with poor prognosis in patients with metastatic colorectal cancer
9P CXCR6+PD-1- Tissue resident memory T cells are associated with poor prognosis in patients with metastatic colorectal cancer Open
View article: Reappraisal of Oncocytic Adenocarcinoma
Reappraisal of Oncocytic Adenocarcinoma Open
Oncocytic adenocarcinoma (OC) of the salivary glands is a rare and controversial entity. It was recently reclassified as “salivary carcinoma NOS and emerging entities” in the 2022 WHO classification of head and neck tumors. The lack of spe…
View article: COL25A1 and METAP1D DNA methylation are promising liquid biopsy epigenetic biomarkers of colorectal cancer using digital PCR
COL25A1 and METAP1D DNA methylation are promising liquid biopsy epigenetic biomarkers of colorectal cancer using digital PCR Open
Bioinformatics analysis of public databases revealed COL25A1 and METAP1D DNA methylation as clinically applicable liquid biopsies DNA methylation biomarkers. The specificity implies an excellent positive predictive value for follow-up, and…
View article: Concomitant decrease of E- and A-FABP expression predicts worse survival in urothelial bladder cancer patients
Concomitant decrease of E- and A-FABP expression predicts worse survival in urothelial bladder cancer patients Open
Non-muscle invasive bladder cancers (NMIBC) pTa-pT1 are depicted by a high risk of recurrence and/or progression with an unpredictable clinical evolution. Our aim was to identify, from the original resection specimen, tumors that will prog…
View article: Temporal and spatial heterogeneity of HER2 status in metastatic colorectal cancer
Temporal and spatial heterogeneity of HER2 status in metastatic colorectal cancer Open
Background HER2-targeted therapies have recently emerged as an option in the management of metastatic colorectal cancer (mCRC) overexpressing HER2. However, data regarding HER2 status in primary CRC and its corresponding liver metastases a…
View article: Prognostic Factors for Long-Term Eribulin Response in a Cohort of Patients With HER2-Negative Metastatic Breast Cancer
Prognostic Factors for Long-Term Eribulin Response in a Cohort of Patients With HER2-Negative Metastatic Breast Cancer Open
Eribulin response in MBC can be driven by clinical and biological factors. Application of our nomogram could assist in the prescription of eribulin.
View article: Biomarqueurs histopronostiques de l'adénocarcinome canalaire du pancréas : évaluation d’un panel immunohistochimique intégrant les trois compartiments tumoraux épithéliaux, fibroblastiques et immunitaires
Biomarqueurs histopronostiques de l'adénocarcinome canalaire du pancréas : évaluation d’un panel immunohistochimique intégrant les trois compartiments tumoraux épithéliaux, fibroblastiques et immunitaires Open
The search for innovative therapeutic approaches is particularly topical in pancreatic ductal adenocarcinoma (PDAC), as its prognosis remains daunting. One of the avenues of exploration lies in the understanding of the mechanisms leading t…
View article: CD3-CD8 immune score associated with a clinical score stratifies PDAC prognosis regardless of adjuvant or neoadjuvant chemotherapy
CD3-CD8 immune score associated with a clinical score stratifies PDAC prognosis regardless of adjuvant or neoadjuvant chemotherapy Open
Stratification of the prognosis of pancreatic cancer (PDAC) patients treated by surgery is based solely on clinical variables, such as tumor stage and node status. The development of biomarkers of relapse is needed, especially to drive adm…
View article: Evaluation of immune infiltrate according to the HER2 status in colorectal cancer
Evaluation of immune infiltrate according to the HER2 status in colorectal cancer Open
View article: 1642P Prognostic impact of an immunomorphological signature integrating immune, fibroblastic and tumor markers in a series of 217 resected pancreatic adenocarcinoma patients
1642P Prognostic impact of an immunomorphological signature integrating immune, fibroblastic and tumor markers in a series of 217 resected pancreatic adenocarcinoma patients Open
View article: Polyploidy, EZH2 upregulation, and transformation in cytomegalovirus-infected human ovarian epithelial cells
Polyploidy, EZH2 upregulation, and transformation in cytomegalovirus-infected human ovarian epithelial cells Open
View article: Data from Prognostic Value of Angiopoietin-2 for Death Risk Stratification in Patients with Metastatic Colorectal Carcinoma
Data from Prognostic Value of Angiopoietin-2 for Death Risk Stratification in Patients with Metastatic Colorectal Carcinoma Open
Background: Baseline prognostic biomarkers stratifying treatment strategies in first-line metastatic colorectal cancer (mCRC) are lacking. Angiopoietin-2 (Ang-2) is proposed as a potential biomarker in several cancers. We therefore …
View article: Supplementary Methods, Table 1 from Prognostic Value of Angiopoietin-2 for Death Risk Stratification in Patients with Metastatic Colorectal Carcinoma
Supplementary Methods, Table 1 from Prognostic Value of Angiopoietin-2 for Death Risk Stratification in Patients with Metastatic Colorectal Carcinoma Open
Supplementary Methods, Table 1. Supplementary methods: - Ang-2 plasma sample measurement - Statistical analysis interpretation Supplementary table 1: - Cox Univariate analyses for OS prediction with and without the stratified approach (sen…
View article: Supplementary Methods, Table 1 from Prognostic Value of Angiopoietin-2 for Death Risk Stratification in Patients with Metastatic Colorectal Carcinoma
Supplementary Methods, Table 1 from Prognostic Value of Angiopoietin-2 for Death Risk Stratification in Patients with Metastatic Colorectal Carcinoma Open
Supplementary Methods, Table 1. Supplementary methods: - Ang-2 plasma sample measurement - Statistical analysis interpretation Supplementary table 1: - Cox Univariate analyses for OS prediction with and without the stratified approach (sen…
View article: Data from Prognostic Value of Angiopoietin-2 for Death Risk Stratification in Patients with Metastatic Colorectal Carcinoma
Data from Prognostic Value of Angiopoietin-2 for Death Risk Stratification in Patients with Metastatic Colorectal Carcinoma Open
Background: Baseline prognostic biomarkers stratifying treatment strategies in first-line metastatic colorectal cancer (mCRC) are lacking. Angiopoietin-2 (Ang-2) is proposed as a potential biomarker in several cancers. We therefore …
View article: CD8+ CD226high T cells in liver metastases dictate the prognosis of colorectal cancer patients treated with chemotherapy and radical surgery
CD8+ CD226high T cells in liver metastases dictate the prognosis of colorectal cancer patients treated with chemotherapy and radical surgery Open
CD226 has been reported to participate in the rescue of CD8 + T cell dysfunction. In this study, we aimed to assess the prognostic value of CD226 in tumor-infiltrating lymphocytes (TILs) derived from colorectal cancer (CRC) liver metastase…
View article: <scp>SALL4</scp> ‐related gene signature defines a specific stromal subset of pancreatic ductal adenocarcinoma with poor prognostic features
<span>SALL4</span> ‐related gene signature defines a specific stromal subset of pancreatic ductal adenocarcinoma with poor prognostic features Open
Pancreatic ductal adenocarcinoma (PDAC) is marked by molecular heterogeneity and poor prognosis. Among the stemness‐related transcription factors, Spalt‐like Transcription Factor 4 (SALL4) is correlated with unfavorable outcomes; however, …
View article: Real-time multiplex PCR for human echinococcosis and differential diagnosis
Real-time multiplex PCR for human echinococcosis and differential diagnosis Open
Molecular identification of rare human infectious pathogens appears to be one of the most relevant current methods for rapid diagnosis and management of patients. PCR techniques, in particular real-time quantitative PCR, are best suited fo…
View article: Prognostic role of HPV integration status and molecular profile in advanced anal carcinoma: An ancillary study to the epitopes-HPV02 trial
Prognostic role of HPV integration status and molecular profile in advanced anal carcinoma: An ancillary study to the epitopes-HPV02 trial Open
Squamous Cell Carcinoma of the Anal canal (SCCA) is a rare disease associated with a Human Papillomavirus (HPV) infection in most cases, predominantly the HPV16 genotype. About 15% of SCCA are diagnosed in metastatic stage and some will re…
View article: Molecular diagnosis of alveolar echinococcosis in patients based on frozen and formalin-fixed paraffin-embedded tissue samples
Molecular diagnosis of alveolar echinococcosis in patients based on frozen and formalin-fixed paraffin-embedded tissue samples Open
Confirmed diagnosis of alveolar echinococcosis (AE) is based on pathological criteria and molecular evidence. This parasite-borne disease, caused by the cestode Echinococcus multilocularis , sparingly involves humans as a dead-end host. In…
View article: Identification of UL69 Gene and Protein in Cytomegalovirus-Transformed Human Mammary Epithelial Cells
Identification of UL69 Gene and Protein in Cytomegalovirus-Transformed Human Mammary Epithelial Cells Open
A growing body of evidence addressing the involvement of human cytomegalovirus (HCMV) in malignancies had directed attention to the oncomodulation paradigm. HCMV-DB infected human mammary epithelial cells (HMECs) in culture showed the emer…
View article: Autophagy is associated with a robust specific transcriptional signature in breast cancer subtypes
Autophagy is associated with a robust specific transcriptional signature in breast cancer subtypes Open
Previous works have described that autophagy could be associated to both pro- and anti-cancer properties according to numerous factors, such as the gene considered, the step of autophagy involved or the cancer model used. These data might …
View article: Immunohistochemistry with anti-MAL antibody and RNAscope with MAL probes are complementary techniques for diagnosis of primary mediastinal large B-cell lymphoma
Immunohistochemistry with anti-MAL antibody and RNAscope with MAL probes are complementary techniques for diagnosis of primary mediastinal large B-cell lymphoma Open
Aims Primary mediastinal large B-cell lymphoma (PMBL) diagnosis can be challenging on needle biopsies. Robust techniques are needed to ensure diagnosis of this lymphoma which is highly sensitive to recently developed therapy protocols. Met…
View article: « Discovering Pathology », un serious game dédié à la découverte de l’anatomopathologie pour les étudiants en médecine
« Discovering Pathology », un serious game dédié à la découverte de l’anatomopathologie pour les étudiants en médecine Open