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View article: How well can a coagulation model be optimized?
How well can a coagulation model be optimized? Open
This study evaluates the performance of optimization strategies across coagulation cascade models of varying complexity, distinguished by differences in the number of species and reactions.The results indicate that increasing model complex…
View article: Multi-step Model Reduction of Coagulation Schemes
Multi-step Model Reduction of Coagulation Schemes Open
This study introduces a comprehensive multi-step reduction technique for coagulation models, specifically targeting the dynamics of thrombin generation. By employing a synergistic approach that combines Direct Relation Graph with Error Pro…
View article: Physics-Guided Neural Networks for Intraventricular Vector Flow Mapping
Physics-Guided Neural Networks for Intraventricular Vector Flow Mapping Open
Intraventricular vector flow mapping (iVFM) seeks to enhance and quantify color Doppler in cardiac imaging. In this study, we propose novel alternatives to the traditional iVFM optimization scheme using physics-informed neural networks (PI…
View article: Physics-Guided Neural Networks for Intraventricular Vector Flow Mapping
Physics-Guided Neural Networks for Intraventricular Vector Flow Mapping Open
Intraventricular vector flow mapping (iVFM) seeks to enhance and quantify color Doppler in cardiac imaging. In this study, we propose novel alternatives to the traditional iVFM optimization scheme by utilizing physics-informed neural netwo…
View article: Critical evaluation of kinetic schemes for coagulation
Critical evaluation of kinetic schemes for coagulation Open
Two well-established numerical representations of the coagulation cascade either initiated by the intrinsic system (Chatterjee et al., PLOS Computational Biology 2010) or the extrinsic system (Butenas et al., Journal of Biological Chemistr…
View article: Assessing a heterogeneous model for accounting for endovascular devices in hemodynamic simulations of cerebral aneurysms
Assessing a heterogeneous model for accounting for endovascular devices in hemodynamic simulations of cerebral aneurysms Open
The heterogeneous model developed by Berod et al [ Int J Numer Method Biomed Eng 38, 2021] for representing the hemodynamic effects of endovascular prostheses is applied to a series of 10 patient specific cerebral aneurysms, 6 being treate…
View article: An adjoint‐based method for the computation of gradients in coagulation schemes
An adjoint‐based method for the computation of gradients in coagulation schemes Open
An adjoint‐based methodology is proposed to compute the gradient of the outcomes of mathematical models for the coagulation cascade. The method is first exposed and validated by considering a simple, analytically tractable case involving o…
View article: Heterogeneous model to evaluate CFD in intracranial bifurcation aneurysms treated with the WEB device to predict angiographic outcome
Heterogeneous model to evaluate CFD in intracranial bifurcation aneurysms treated with the WEB device to predict angiographic outcome Open
Introduction The Woven EndoBridge device (WEB) was developed as an alternative to treat Wide-Necked bifurcation aneurysms. It has proven to be effective and safe, however, cases of recanalization have been reported. The purpose of this stu…
View article: Red blood cell rheology during a complete blood count: A proof of concept
Red blood cell rheology during a complete blood count: A proof of concept Open
Counting and sizing blood cells in hematological analyzers is achieved using the Coulter principle. The cells flow in a micro-aperture in which a strong electrical field is imposed, so that an electrical perturbation, called pulse, is meas…
View article: Geometry of intracranial aneurysms and of intrasaccular devices may influence aneurysmal occlusion rates after endovascular treatment
Geometry of intracranial aneurysms and of intrasaccular devices may influence aneurysmal occlusion rates after endovascular treatment Open
Introduction The Woven EndoBridge device (WEB) is used to treat wide-neck bifurcation aneurysms. These devices are deployed inside the sac. Therefore, the mesh structure provides apposition with the aneurysm wall and induces aneurysmal thr…
View article: Large eddy simulation study of the impact of an obstacle on cooling properties of a multiperforated liner
Large eddy simulation study of the impact of an obstacle on cooling properties of a multiperforated liner Open
Large eddy simulations are performed to investigate the impact of a solid obstacle on the flow around a multiperforated plate typical of aeronautical combustion chambers. The reference configuration is a perforated plate with approximately…
View article: Validation of three-dimensional printed models of intracranial aneurysms
Validation of three-dimensional printed models of intracranial aneurysms Open
Introduction Three-dimensional (3D) printing has evolved for medical applications as it can produce customized 3D models of devices and implants that can improve patient care. In this study, we aimed to validate the geometrical accuracy of…
View article: Accelerated sequences of 4D flow MRI using GRAPPA and compressed sensing: A comparison against conventional MRI and computational fluid dynamics
Accelerated sequences of 4D flow MRI using GRAPPA and compressed sensing: A comparison against conventional MRI and computational fluid dynamics Open
Purpose To evaluate hemodynamic markers obtained by accelerated GRAPPA ( R = 2, 3, 4) and compressed sensing ( R = 7.6) 4D flow MRI sequences under complex flow conditions. Methods The accelerated 4D flow MRI scans were performed on a puls…
View article: A Pipeline for the Generation of Synthetic Cardiac Color Doppler
A Pipeline for the Generation of Synthetic Cardiac Color Doppler Open
Color Doppler imaging (CDI) is the modality of choice for simultaneous visualization of myocardium and intracavitary flow over a wide scan area. This visualization modality is subject to several sources of error, the main ones being aliasi…
View article: Clinical impact of Sim & Size<sup>®</sup> simulation software in the treatment of patients with cerebral aneurysms with flow-diverter Pipeline stents
Clinical impact of Sim & Size<sup>®</sup> simulation software in the treatment of patients with cerebral aneurysms with flow-diverter Pipeline stents Open
Objectives This study evaluated the clinical impact of the Sim&Size® simulation software on the endovascular treatment with flow-diverter stents of patients with unruptured saccular intracranial aneurysms. Methods This monocentric retrospe…
View article: Physics-constrained intraventricular vector flow mapping by color Doppler
Physics-constrained intraventricular vector flow mapping by color Doppler Open
Color Doppler by transthoracic echocardiography creates two-dimensional fan-shaped maps of blood velocities in the cardiac cavities. It is a one-component velocimetric technique since it only returns the velocity components parallel to the…
View article: A heterogeneous model of endovascular devices for the treatment of intracranial aneurysms
A heterogeneous model of endovascular devices for the treatment of intracranial aneurysms Open
Numerical computations of hemodynamics inside intracranial aneurysms treated by endovascular braided devices such as flow‐diverters contribute to understanding and improving such treatment procedures. Nevertheless, these simulations yield …
View article: Low-Order Thermoacoustic Analysis of Real Engines
Low-Order Thermoacoustic Analysis of Real Engines Open
This article illustrates the capability of the recently introduced low-order acoustic-network modeling (LOM) approach (Laurent et al., Combust. Flame, vol. 206, 2019) based on the ’generalized modal-expansions’ and the ’state-space’ framew…
View article: Stochastic forcing for sub-grid scale models in wall-modeled large-eddy simulation
Stochastic forcing for sub-grid scale models in wall-modeled large-eddy simulation Open
In the framework of wall-modeled large-eddy simulation (WMLES), the problem of combining sub-grid scale (SGS) models with the standard wall law is commonly acknowledged and expressed through multiple undesired near-wall behaviors. In this …
View article: Detecting cells rotations for increasing the robustness of cell sizing by impedance measurements, with or without machine learning
Detecting cells rotations for increasing the robustness of cell sizing by impedance measurements, with or without machine learning Open
The Coulter principle is a widespread technique for sizing red blood cells (RBCs) in hematological analyzers. It is based on the monitoring of the electrical perturbations generated by cells passing through a micro‐orifice, in which a conc…
View article: Impact of the membrane viscosity on the tank-treading behavior of red blood cells
Impact of the membrane viscosity on the tank-treading behavior of red blood cells Open
Numerical simulations are used to compare the impact of the internal fluid viscosity and the membrane viscosity on an isolated tank-treading red blood cell. Both decrease the tank-treading frequency, with moderate changes in the deformatio…
View article: Critical evaluation of kinetic schemes for coagulation
Critical evaluation of kinetic schemes for coagulation Open
Computational models of the coagulation cascade are used for a wide range of applications in bio-medical engineering such as drug and bio-medical device developments. However, a lack of robustness of numerical models has been highlighted w…
View article: Numerical simulation of time-resolved 3D phase-contrast magnetic resonance imaging
Numerical simulation of time-resolved 3D phase-contrast magnetic resonance imaging Open
A numerical approach is presented to efficiently simulate time-resolved 3D phase-contrast Magnetic resonance Imaging (or 4D Flow MRI) acquisitions under realistic flow conditions. The Navier-Stokes and Bloch equations are simultaneously so…