François Boudet-Devaud
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View article: Titanium dioxide and carbon black nanoparticles disrupt neuronal homeostasis via excessive activation of cellular prion protein signaling
Titanium dioxide and carbon black nanoparticles disrupt neuronal homeostasis via excessive activation of cellular prion protein signaling Open
Background Epidemiological emerging evidence shows that human exposure to some nanosized materials present in the environment would contribute to the onset and/or progression of Alzheimer’s disease (AD). The cellular and molecular mechanis…
View article: Production of seedable Amyloid-β peptides in model of prion diseases upon PrPSc-induced PDK1 overactivation
Production of seedable Amyloid-β peptides in model of prion diseases upon PrPSc-induced PDK1 overactivation Open
The presence of amyloid beta (Aβ) plaques in the brain of some individuals with Creutzfeldt-Jakob or Gertsmann-Straussler-Scheinker diseases suggests that pathogenic prions (PrP Sc ) would have stimulated the production and deposition of A…
View article: Protective role of cellular prion protein against TNFα-mediated inflammation through TACE α-secretase
Protective role of cellular prion protein against TNFα-mediated inflammation through TACE α-secretase Open
Although cellular prion protein PrP C is well known for its implication in Transmissible Spongiform Encephalopathies, its functions remain elusive. Combining in vitro and in vivo approaches, we here show that PrP C displays the intrinsic c…
View article: Cerebellar compartmentation of prion pathogenesis
Cerebellar compartmentation of prion pathogenesis Open
In prion diseases, the brain lesion profile is influenced by the prion “strain” properties, the invasion route to the brain, and still unknown host cell‐specific parameters. To gain insight into those endogenous factors, we analyzed the hi…