François Mesnard
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View article: Combining Stable Isotope Labeling and Candidate Substrate–Product Pair Networks Reveals Lignan, Oligolignol, and Chicoric Acid Biosynthesis in Flax Seedlings (Linum usitatissimum L.)
Combining Stable Isotope Labeling and Candidate Substrate–Product Pair Networks Reveals Lignan, Oligolignol, and Chicoric Acid Biosynthesis in Flax Seedlings (Linum usitatissimum L.) Open
Functional foods like flax (Linum usitatissimum L.) are rich sources of specialized metabolites that contribute to their nutritional and health-promoting properties. Understanding the biosynthesis of these compounds is essential for improv…
View article: Phenolic compounds fingerprints show distinct ligninolytic bacteria behaviours during technical lignins conversion
Phenolic compounds fingerprints show distinct ligninolytic bacteria behaviours during technical lignins conversion Open
Lignins, one of the main components of plant cell wall, and by-products of certain industries (paper and wood industries,…) are a renewable source of aromatic molecules. They can be degraded and transformed by microbial and enzymatic proce…
View article: Elicitor-driven enhancement of phenolic compounds in geranium callus cultures: phytochemical profiling via LC-MS/MS and biological activities
Elicitor-driven enhancement of phenolic compounds in geranium callus cultures: phytochemical profiling via LC-MS/MS and biological activities Open
This research explores the effects of chitosan (CHT) and salicylic acid (SA) as elicitors on the production of phenolic and flavonoid compounds in Pelargonium graveolens Hort. Callus cultures on solid media, aiming to enhance antioxidant, …
View article: Biochemical insights into specialized plant metabolites: Advancing cosmeceutical applications for skin benefits
Biochemical insights into specialized plant metabolites: Advancing cosmeceutical applications for skin benefits Open
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View article: Optimization of the Antibacterial Activity of a Three-Component Essential Oil Mixture from Moroccan Thymus satureioides, Lavandula angustifolia, and Origanum majorana Using a Simplex–Centroid Design
Optimization of the Antibacterial Activity of a Three-Component Essential Oil Mixture from Moroccan Thymus satureioides, Lavandula angustifolia, and Origanum majorana Using a Simplex–Centroid Design Open
Background/Objectives: The rise of antibiotic-resistant pathogens has become a global health crisis, necessitating the development of alternative antimicrobial strategies. This study aimed to optimize the antibacterial effects of essential…
View article: NMR and LC-MS-Based Metabolomics to Study the Effect of Surfactin on the Metabolome of Flax
NMR and LC-MS-Based Metabolomics to Study the Effect of Surfactin on the Metabolome of Flax Open
Flax (Linum usitatissimum) is a versatile plant used in a range of applications, from textiles to nutrition. Surfactin, a cyclic lipopeptide biosurfactant produced by bacteria such as Bacillus subtilis, has potential as a biocontrol agent …
View article: Formulation of a Three-Component Essential Oil Mixture from Lavandula dentata, Rosmarinus officinalis, and Myrtus communis for Improved Antioxidant Activity
Formulation of a Three-Component Essential Oil Mixture from Lavandula dentata, Rosmarinus officinalis, and Myrtus communis for Improved Antioxidant Activity Open
The optimization of existing natural antioxidants that are highly effective is crucial for advancements in medicine and the food industry. Due to growing concerns regarding the safety of synthetic antioxidants, researchers are increasingly…
View article: Antioxidant Active Phytochemicals in Ternstroemia lineata Explained by Aquaporin Mechanisms
Antioxidant Active Phytochemicals in Ternstroemia lineata Explained by Aquaporin Mechanisms Open
The antioxidant action of terngymnoside C (1) and hydroxytyrosol-1-glucoside (2), isolated for the first time from the flower buds of Ternstroemia lineata, as well as katsumadin (3), obtained from the seedless fruits, was evaluated using A…
View article: Antimicrobial Plants Used by Fang Populations and Phytochemical Profiling of Erismadelphus exsul
Antimicrobial Plants Used by Fang Populations and Phytochemical Profiling of Erismadelphus exsul Open
Gabon has a rich flora, many species of which are used in traditional medicine. However, little research has been carried out on this wealth. An ethnopharmacological survey in the Fang language was carried out among traditional practitione…
View article: Investigation of the reproducibility of the treatment efficacy of a commercial bio stimulant using metabolic profiling on flax
Investigation of the reproducibility of the treatment efficacy of a commercial bio stimulant using metabolic profiling on flax Open
The choice of an optimal bio stimulant in agriculture is challenging as it depends on the production system implemented, such as the crop, plant model, soil, climate, and farmer’s practices. Thus, understanding bio stimulant–plant interact…
View article: NMR and LC–MS-based metabolomics to investigate the efficacy of a commercial bio stimulant for the treatment of wheat (Triticum aestivum)
NMR and LC–MS-based metabolomics to investigate the efficacy of a commercial bio stimulant for the treatment of wheat (Triticum aestivum) Open
Introduction Bio stimulants are substances and/or microorganisms that are used to improve plant growth and crop yields by modulating physiological processes and metabolism of plants. While research has primarily focused on the broad effect…
View article: Enhancing Secondary Metabolite Production in Pelargonium graveolens Hort. Cell Cultures: Eliciting Effects of Chitosan and Jasmonic Acid on Bioactive Compound Production
Enhancing Secondary Metabolite Production in Pelargonium graveolens Hort. Cell Cultures: Eliciting Effects of Chitosan and Jasmonic Acid on Bioactive Compound Production Open
This study explores the effects of chitosan (CHT) and jasmonic acid (JA) elicitors on rose-scented geranium (Pelargonium graveolens Hort.) cell suspension cultures, aiming to enhance the production of phenolics and flavonoids and antioxida…
View article: Cytotoxicity and Identification of Antibacterial Compounds from Baillonella toxisperma Bark Using a LC-MS/MS and Molecular Networking Approach
Cytotoxicity and Identification of Antibacterial Compounds from Baillonella toxisperma Bark Using a LC-MS/MS and Molecular Networking Approach Open
Baillonella toxisperma is a medicinal plant used in northern Gabon to treat microbial diseases. It is a plant well-known by local populations, but very few studies have focused on the molecules responsible for the antibacterial activities …
View article: Laurus nobilis Leaves and Fruits: A Review of Metabolite Composition and Interest in Human Health
Laurus nobilis Leaves and Fruits: A Review of Metabolite Composition and Interest in Human Health Open
Laurus nobilis belongs to the family Lauraceae and is characterized by its evergreen nature. It is well known because of its traditional use in cooking and folk medicine. Many studies have been performed regarding its chemical composition …
View article: Combined LC-MS/MS and Molecular Networking Approach Reveals Antioxidant and Antimicrobial Compounds from Erismadelphus exsul Bark
Combined LC-MS/MS and Molecular Networking Approach Reveals Antioxidant and Antimicrobial Compounds from Erismadelphus exsul Bark Open
Erismadelphus exsul Mildbr bark is widely used in Gabonese folk medicine. However, little is known about the active compounds associated with its biological activities. In the present study, phytochemical profiling of the ethanolic extract…
View article: Integument-Specific Transcriptional Regulation in the Mid-Stage of Flax Seed Development Influences the Release of Mucilage and the Seed Oil Content
Integument-Specific Transcriptional Regulation in the Mid-Stage of Flax Seed Development Influences the Release of Mucilage and the Seed Oil Content Open
Flax (Linum usitatissimum L.) seed oil, which accumulates in the embryo, and mucilage, which is synthesized in the seed coat, are of great economic importance for food, pharmaceutical as well as chemical industries. Theories on the link be…
View article: INTEGUMENT-SPECIFIC TRANSCRIPTIONAL REGULATION IN THE MID-STAGE OF FLAX SEED DEVELOPMENT INFLUENCES THE RELEASE OF MUCILAGE AND THE SEED OIL CONTENT
INTEGUMENT-SPECIFIC TRANSCRIPTIONAL REGULATION IN THE MID-STAGE OF FLAX SEED DEVELOPMENT INFLUENCES THE RELEASE OF MUCILAGE AND THE SEED OIL CONTENT Open
Flax ( Linum usitatissimum L.) seed oil, which accumulates in the embryo, and mucilage, which is synthesized in the seed coat, are of great economic importance for food, pharmaceutical as well as chemical industries. Theories on the link b…
View article: NMR and LC-MS-Based Metabolomics to Study Osmotic Stress in Lignan-Deficient Flax
NMR and LC-MS-Based Metabolomics to Study Osmotic Stress in Lignan-Deficient Flax Open
Lignans, phenolic plant secondary metabolites, are derived from the phenylpropanoid biosynthetic pathway. Although, being investigated for their health benefits in terms of antioxidant, antitumor, anti-inflammatory and antiviral properties…
View article: Age-Dependent Metabolic Profiles Unravel the Metabolic Relationships within and between Flax Leaves (Linum usitatissimum)
Age-Dependent Metabolic Profiles Unravel the Metabolic Relationships within and between Flax Leaves (Linum usitatissimum) Open
Flax for oil seed is a crop of increasing popularity, but its cultivation needs technical improvement. Important agronomic traits such as productivity and resistance to stresses are to be regarded as the result of the combined responses of…
View article: An untargeted liquid chromatography–mass spectrometry‐based workflow for the structural characterization of plant polyesters
An untargeted liquid chromatography–mass spectrometry‐based workflow for the structural characterization of plant polyesters Open
Summary Cell wall localized heterogeneous polyesters are widespread in land plants. The composition of these polyesters, such as cutin, suberin, or more plant‐specific forms such as the flax seed coat lignan macromolecule, can be determine…
View article: Phenolic Profiling of Flax Highlights Contrasting Patterns in Winter and Spring Varieties
Phenolic Profiling of Flax Highlights Contrasting Patterns in Winter and Spring Varieties Open
Flax (Linum usitatissimum) is a plant grown in temperate regions either for its fiber or for its seeds, which are rich in the essential fatty acid omega-3. It is also well known as a source of medicinal compounds. The chemical composition …
View article: Cytological Approaches Combined With Chemical Analysis Reveals the Layered Nature of Flax Mucilage
Cytological Approaches Combined With Chemical Analysis Reveals the Layered Nature of Flax Mucilage Open
The external seed coat cell layer of certain species is specialized in the production and extrusion of a polysaccharide matrix called mucilage. Variations in the content of the released mucilage have been mainly associated with genetically…
View article: A Deeper Investigation of Drug Degradation Mixtures Using a Combination of MS and NMR Data: Application to Indapamide
A Deeper Investigation of Drug Degradation Mixtures Using a Combination of MS and NMR Data: Application to Indapamide Open
A global approach that is based on a combination of mass spectrometry (MS) and nuclear magnetic resonance (NMR) data has been developed for a complete and rapid understanding of drug degradation mixtures. We proposed a workflow based on a …
View article: Insight into the Influence of Cultivar Type, Cultivation Year, and Site on the Lignans and Related Phenolic Profiles, and the Health-Promoting Antioxidant Potential of Flax (Linum usitatissimum L.) Seeds
Insight into the Influence of Cultivar Type, Cultivation Year, and Site on the Lignans and Related Phenolic Profiles, and the Health-Promoting Antioxidant Potential of Flax (Linum usitatissimum L.) Seeds Open
Flaxseeds are a functional food representing, by far, the richest natural grain source of lignans, and accumulate substantial amounts of other health beneficial phenolic compounds (i.e., flavonols, hydroxycinnamic acids). This specific acc…