François Payre
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View article: Elimination of cells with local mismatch in differentiation timing contributes to synchronize tissue development
Elimination of cells with local mismatch in differentiation timing contributes to synchronize tissue development Open
During animal development, cells communicate to ensure tissue-wide synchronization of differentiation. While several mechanisms contributing to cell coordination have been described, whether additional mechanisms are at play should cells l…
View article: 3D dynamics of <i>trans</i> enhancer-promoter interactions in living <i>Drosophila embryos</i> reveals spatiotemporal thresholds for transcription activation
3D dynamics of <i>trans</i> enhancer-promoter interactions in living <i>Drosophila embryos</i> reveals spatiotemporal thresholds for transcription activation Open
While it is well acknowledged that specific enhancer-promoter interactions are essential for transcription, the spatiotemporal thresholds required for transcription initiation remain unclear. Here, we employed the phenomenon of transvectio…
View article: Pri peptides temporally coordinate transcriptional programs during epidermal differentiation
Pri peptides temporally coordinate transcriptional programs during epidermal differentiation Open
To achieve a highly differentiated state, cells undergo multiple transcriptional processes whose coordination and timing are not well understood. In Drosophila embryonic epidermal cells, polished-rice (Pri) smORF peptides act as temporal m…
View article: Crosstalk between chromatin and Shavenbaby defines transcriptional output along the Drosophila intestinal stem cell lineage
Crosstalk between chromatin and Shavenbaby defines transcriptional output along the Drosophila intestinal stem cell lineage Open
View article: The pleiotropic functions of Pri smORF peptides synchronize leg development regulators
The pleiotropic functions of Pri smORF peptides synchronize leg development regulators Open
The last decade witnesses the emergence of the abundant family of smORF peptides, encoded by small ORF (<100 codons), whose biological functions remain largely unexplored. Bioinformatic analyses here identify hundreds of putative smORF pep…
View article: The pleiotropic functions of Pri smORF peptides synchronise leg development regulators
The pleiotropic functions of Pri smORF peptides synchronise leg development regulators Open
The last decade witnesses the emergence of the abundant family of smORF peptides, encoded by small ORF (<100 codons), whose biological functions remain largely unexplored. Bioinformatic analyses here identify hundreds of putative smORF pep…
View article: Crosstalk between chromatin and the transcription factor Shavenbaby defines transcriptional output along the<i>Drosophila</i>intestinal stem cell lineage
Crosstalk between chromatin and the transcription factor Shavenbaby defines transcriptional output along the<i>Drosophila</i>intestinal stem cell lineage Open
Summary The transcription factor Shavenbaby (Svb), the only member of the OvoL family in Drosophila , controls intestinal stem cell differentiation. Post-translational modification of Svb produces two protein isoforms, Svb-ACT and Svb-REP,…
View article: Crosstalk between Chromatin and the Transcription Factor Shavenbaby Defines Transcriptional Output Along the <i>Drosophila</i> Intestinal Stem Cell Lineage
Crosstalk between Chromatin and the Transcription Factor Shavenbaby Defines Transcriptional Output Along the <i>Drosophila</i> Intestinal Stem Cell Lineage Open
View article: Pri smORF Peptides Are Wide Mediators of Ecdysone Signaling, Contributing to Shape Spatiotemporal Responses
Pri smORF Peptides Are Wide Mediators of Ecdysone Signaling, Contributing to Shape Spatiotemporal Responses Open
There is growing evidence that peptides encoded by small open-reading frames (sORF or smORF) can fulfill various cellular functions and define a novel class regulatory molecules. To which extend transcripts encoding only smORF peptides com…
View article: Steroid‐dependent switch of OvoL/Shavenbaby controls self‐renewal versus differentiation of intestinal stem cells
Steroid‐dependent switch of OvoL/Shavenbaby controls self‐renewal versus differentiation of intestinal stem cells Open
View article: Les facteurs OvoL
Les facteurs OvoL Open
Des avancées majeures révèlent l’hétérogénéité intra-tumorale des cancers d’origine épithéliale, incluant des cellules initiatrices de tumeurs qui ressemblent aux cellules souches adultes. Les cellules souches normales et tumorales partage…
View article: Shavenbaby protein isoforms orchestrate the self-renewal<i>versus</i>differentiation of<i>Drosophila</i>intestinal stem cells
Shavenbaby protein isoforms orchestrate the self-renewal<i>versus</i>differentiation of<i>Drosophila</i>intestinal stem cells Open
SUMMARY Signaling pathways are key regulators of adult stem cell homeostasis and underlying mechanisms are often deregulated in cancers. Recent studies of epithelial tumors have involved OvoL/Svb transcription factors, which produce isofor…
View article: The mlpt/Ubr3/Svb module comprises an ancient developmental switch for embryonic patterning
The mlpt/Ubr3/Svb module comprises an ancient developmental switch for embryonic patterning Open
Small open reading frames (smORFs) encoding ‘micropeptides’ exhibit remarkable evolutionary complexity. Conserved peptides encoded by mille-pattes (mlpt)/polished rice (pri)/tarsal less (tal) are essential for embryo segmentation in Tribol…
View article: Author response: The mlpt/Ubr3/Svb module comprises an ancient developmental switch for embryonic patterning
Author response: The mlpt/Ubr3/Svb module comprises an ancient developmental switch for embryonic patterning Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Small open reading frames (smORFs) encodin…
View article: Shavenbaby and Yorkie mediate Hippo signaling to protect adult stem cells from apoptosis
Shavenbaby and Yorkie mediate Hippo signaling to protect adult stem cells from apoptosis Open
To compensate for accumulating damages and cell death, adult homeostasis (e.g., body fluids and secretion) requires organ regeneration, operated by long-lived stem cells. How stem cells can survive throughout the animal life remains poorly…
View article: <i>millepattes</i>micropeptides are an ancient developmental switch required for embryonic patterning
<i>millepattes</i>micropeptides are an ancient developmental switch required for embryonic patterning Open
Summary Small open reading frames (smORFs) that code for “micropeptides” (10-100 amino acids) exhibit remarkable evolutionary complexity. Conserved micropeptides encoded by the millepattes (mlpt) gene are essential in Tribolium for embryog…
View article: Activation of the Notch Signaling Pathway In Vivo Elicits Changes in CSL Nuclear Dynamics
Activation of the Notch Signaling Pathway In Vivo Elicits Changes in CSL Nuclear Dynamics Open
View article: Crumbs, Moesin and Yurt regulate junctional stability and dynamics for a proper morphogenesis of the Drosophila pupal wing epithelium
Crumbs, Moesin and Yurt regulate junctional stability and dynamics for a proper morphogenesis of the Drosophila pupal wing epithelium Open
View article: Shavenbaby and Yorkie mediate Hippo signaling to protect adult stem cells from apoptosis
Shavenbaby and Yorkie mediate Hippo signaling to protect adult stem cells from apoptosis Open
To compensate for accumulating damages and cell death, adult homeostasis (e.g., body fluids and secretion) requires organ regeneration, operated by long-lived stem cells. How stem cells can survive throughout the animal life yet remains po…
View article: Small peptides control heart activity
Small peptides control heart activity Open
Peptides from long noncoding RNAs control a muscle calcium pump [Also see Report by Nelson et al. ]
View article: Pri sORF peptides induce selective proteasome-mediated protein processing
Pri sORF peptides induce selective proteasome-mediated protein processing Open
Small peptide regulates protein activity Coding and noncoding RNAs can produce peptides from small open reading frames (smORFs), with a variety of mostly unknown functions. Using a genome-wide screen, Zanet et al. show that Polished rice (…