Frank Beier
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View article: Severe osteoarthritis in aged PANX3 knockout mice: implications for a novel primary osteoarthritis model
Severe osteoarthritis in aged PANX3 knockout mice: implications for a novel primary osteoarthritis model Open
Osteoarthritis (OA) is a multifactorial disease associated with aging. As the molecular mechanisms underpinning the pathogenesis of this disease are unclear, there are no disease-modifying drugs to combat OA. Pannexin 3 (PANX3) has been sh…
View article: <i>Pannexin 3</i> deletion in mice results in knee osteoarthritis and intervertebral disc degeneration after forced treadmill running
<i>Pannexin 3</i> deletion in mice results in knee osteoarthritis and intervertebral disc degeneration after forced treadmill running Open
Pannexin 3 ( Panx3 ) is a glycoprotein that forms mechanosensitive channels expressed in chondrocytes and annulus fibrosus cells of the intervertebral disc (IVD). Evidence suggests Panx3 plays contrasting roles in traumatic versus aging os…
View article: Comparative histopathological analysis of age‐associated intervertebral disc degeneration in <scp>CD‐1</scp> and <scp>C57BL/6</scp> mice: Anatomical and sex‐based differences
Comparative histopathological analysis of age‐associated intervertebral disc degeneration in <span>CD‐1</span> and <span>C57BL/6</span> mice: Anatomical and sex‐based differences Open
Background Intervertebral disc (IVD) degeneration is a major contributor to back pain and disability. The cause of IVD degeneration is multifactorial, with no disease‐modifying treatments. Mouse models are commonly used to study IVD degene…
View article: Adseverin, an actin-binding protein, modulates hypertrophic chondrocyte differentiation and osteoarthritis progression
Adseverin, an actin-binding protein, modulates hypertrophic chondrocyte differentiation and osteoarthritis progression Open
In osteoarthritis (OA), a disease characterized by progressive articular cartilage degradation and calcification, the articular chondrocyte phenotype changes and this correlates with actin cytoskeleton alterations suggesting that it regula…
View article: Anabolic phenotype in cartilage-specific mitogen-inducible gene-6 knockout mice is independent of transforming growth factor-α
Anabolic phenotype in cartilage-specific mitogen-inducible gene-6 knockout mice is independent of transforming growth factor-α Open
The articular cartilage displays increased thickness/cell density and CON formation independent of the presence of TGFα, suggesting the anabolic phenotype in the Mig6-deficient mice is independent of TGFα/EGFR binding. The anabolic phenoty…
View article: Severe Osteoarthritis in Aged PANX3 Knockout Mice: Implications for a Novel Primary Osteoarthritis Model
Severe Osteoarthritis in Aged PANX3 Knockout Mice: Implications for a Novel Primary Osteoarthritis Model Open
Osteoarthritis (OA) is a multi-factorial disease associated with aging. As the molecular mechanisms underpinning the pathogenesis of this disease are unclear, there are no disease-modifying drugs to combat OA. Pannexin 3 (PANX3) has been s…
View article: First-in-human phase Ib trial of M9241 (NHS-IL12) plus avelumab in patients with advanced solid tumors, including dose expansion in patients with advanced urothelial carcinoma
First-in-human phase Ib trial of M9241 (NHS-IL12) plus avelumab in patients with advanced solid tumors, including dose expansion in patients with advanced urothelial carcinoma Open
Background In preclinical studies, combining M9241 (a novel immunocytokine containing interleukin (IL)-12 heterodimers) with avelumab (anti-programmed death ligand 1 antibody) resulted in additive or synergistic antitumor effects. We repor…
View article: <i>Pannexin 3</i>deletion in mice results in knee osteoarthritis and intervertebral disc degeneration after forced treadmill running
<i>Pannexin 3</i>deletion in mice results in knee osteoarthritis and intervertebral disc degeneration after forced treadmill running Open
Pannexin 3 ( Panx3 ) is a glycoprotein that forms mechanosensitive channels expressed in chondrocytes and annulus fibrosus cells of the intervertebral disc (IVD). Evidence suggests Panx3 plays contrasting roles in traumatic versus aging os…
View article: Anabolic phenotype in cartilage-specific Mitogen-inducible gene-6 knockout mice is independent of Transforming growth factor-<i>α</i>
Anabolic phenotype in cartilage-specific Mitogen-inducible gene-6 knockout mice is independent of Transforming growth factor-<i>α</i> Open
Background/Objective Osteoarthritis (OA) is a whole joint disorder with no disease modifying treatment currently available. The Epidermal Growth Factor Receptor (EGFR) signaling pathway plays an important role in cartilage/bone development…
View article: A Na+/K+ ATPase Pump Regulates Chondrocyte Differentiation and Bone Length Variation in Mice
A Na+/K+ ATPase Pump Regulates Chondrocyte Differentiation and Bone Length Variation in Mice Open
The genetic and developmental mechanisms involved in limb formation are relatively well documented, but how these mechanisms are modulated by changes in chondrocyte physiology to produce differences in limb bone length remains unclear. Her…
View article: Genetic Deletion of Interleukin-15 Is Not Associated with Major Structural Changes Following Experimental Post-Traumatic Knee Osteoarthritis in Rats
Genetic Deletion of Interleukin-15 Is Not Associated with Major Structural Changes Following Experimental Post-Traumatic Knee Osteoarthritis in Rats Open
Post-traumatic osteoarthritis (PTOA) is a degenerative joint disease, leading to articular cartilage breakdown, osteophyte formation, and synovitis, caused by an initial joint trauma. Pro-inflammatory cytokines increase catabolic activity …
View article: Pannexin 3 deletion reduces fat accumulation and inflammation in a sex-specific manner
Pannexin 3 deletion reduces fat accumulation and inflammation in a sex-specific manner Open
Background Pannexin 3 (PANX3), is a channel-forming glycoprotein that enables nutrient-induced inflammation in vitro , and genetic linkage data suggests it regulates body mass index. Here, we characterized inflammatory and metabolic parame…
View article: Genetic deletion of interleukin-15 is not associated with major structural changes following experimental post-traumatic knee osteoarthritis in rats
Genetic deletion of interleukin-15 is not associated with major structural changes following experimental post-traumatic knee osteoarthritis in rats Open
Post-traumatic Osteoarthritis (PTOA) is a degenerative joint disease, leading to articular cartilage breakdown, osteophyte formation, and synovitis, caused by an initial joint trauma. Pro-inflammatory cytokines increase catabolic activity …
View article: The Role of Panx3 in Age-Associated and Injury-Induced Intervertebral Disc Degeneration
The Role of Panx3 in Age-Associated and Injury-Induced Intervertebral Disc Degeneration Open
Pannexin 3 (Panx3) is a mechanosensitive, channel-forming glycoprotein implicated in the progression of post-traumatic osteoarthritis. Despite evidence for Panx3 expression in the intervertebral disc (IVD), its function in this cartilagino…
View article: Targeting cartilage EGFR pathway for osteoarthritis treatment
Targeting cartilage EGFR pathway for osteoarthritis treatment Open
EGFR activation by overexpressing HBEGF in cartilage or intra-articular delivery of TGFα nanoparticles attenuates osteoarthritis development in mice.
View article: Activating EGFR Signaling Attenuates Osteoarthritis Development Following Loading Injury in Mice
Activating EGFR Signaling Attenuates Osteoarthritis Development Following Loading Injury in Mice Open
Posttraumatic osteoarthritis (PTOA) results in joint pain, loss of joint function, and impaired quality of daily life in patients with limited treatment options. We previously demonstrated that epidermal growth factor receptor (EGFR) signa…
View article: EGFR Signaling Is Required for Maintaining Adult Cartilage Homeostasis and Attenuating Osteoarthritis Progression
EGFR Signaling Is Required for Maintaining Adult Cartilage Homeostasis and Attenuating Osteoarthritis Progression Open
The uppermost superficial zone of articular cartilage is the first line of defense against the initiation of osteoarthritis (OA). We previously used Col2-Cre to demonstrate that epidermal growth factor receptor (EGFR), a tyrosine kinase re…
View article: 265 Phase 1b study of avelumab + M9241 (NHS-IL12) in patients with advanced solid tumors: interim analysis results from a urothelial carcinoma (UC) dose-expansion cohort
265 Phase 1b study of avelumab + M9241 (NHS-IL12) in patients with advanced solid tumors: interim analysis results from a urothelial carcinoma (UC) dose-expansion cohort Open
Background Avelumab is an anti–PD-L1 monoclonal antibody approved for the treatment of advanced UC after disease progression during or following platinum-based chemotherapy and as maintenance treatment in patients whose disease has not pro…
View article: Diet-induced Obesity Leads to Behavioral Indicators of Pain Preceding Structural Joint Damage in Wild-Type Mice.
Diet-induced Obesity Leads to Behavioral Indicators of Pain Preceding Structural Joint Damage in Wild-Type Mice. Open
Introduction: Obesity is one of the largest modifiable risk factors for the development of musculoskeletal diseases, including intervertebral disc (IVD) degeneration and back pain. Despite the clinical association, no studies have directly…
View article: Glycogen synthase kinase 3 alpha/beta deletion induces precocious growth plate remodeling and cell loss in mice
Glycogen synthase kinase 3 alpha/beta deletion induces precocious growth plate remodeling and cell loss in mice Open
Glycogen synthase kinase (GSK) 3 acts to negatively regulate multiple signaling pathways, including canonical Wnt signaling. The two mammalian GSK3 proteins (alpha and beta) are at least partially redundant. While Gsk3a KO mice are viable …
View article: GSK3787-Loaded Poly(Ester Amide) Particles for Intra-Articular Drug Delivery
GSK3787-Loaded Poly(Ester Amide) Particles for Intra-Articular Drug Delivery Open
Osteoarthritis (OA) is a debilitating joint disorder affecting more than 240 million people. There is no disease modifying therapeutic, and drugs that are used to alleviate OA symptoms result in side effects. Recent research indicates that…