Frank Blaser
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View article: Visual field testing and fitness to drive in Europe: A cross‐country comparison against a potential reference standard
Visual field testing and fitness to drive in Europe: A cross‐country comparison against a potential reference standard Open
Purpose The purpose of this study was to assess the agreement between the European Driving Test (EDT)—a new perimetry test designed to comply with the visual field requirements for Group 1 drivers outlined in the European Commission Direct…
View article: CRISPR/Cas-mediated activation of genes associated with inherited retinal dystrophies in human cells for diagnostic purposes
CRISPR/Cas-mediated activation of genes associated with inherited retinal dystrophies in human cells for diagnostic purposes Open
Many patients suffering from inherited diseases do not receive a genetic diagnosis and are therefore excluded as candidates for treatments, such as gene therapies. Analyzing disease gene transcripts from patient cells holds potential for d…
View article: A novel multiplex RNAi therapy simultaneously targets Hif1a and Hif2a to defy retinal degeneration in two models of AMD
A novel multiplex RNAi therapy simultaneously targets Hif1a and Hif2a to defy retinal degeneration in two models of AMD Open
Age-related tissue changes lead to reduced oxygen delivery to photoreceptors and the retinal pigment epithelium (RPE) and contribute to the pathology of age-related macular degeneration (AMD). The implication of hypoxia-inducible factors (…
View article: Objective Quality Assessment of the Capsulorhexis – A Novel Augmented Reality Tool for Trainees and Experts
Objective Quality Assessment of the Capsulorhexis – A Novel Augmented Reality Tool for Trainees and Experts Open
Augmented reality can assist in cataract training. The Custom Surgical MicroREC system can have a positive influence on capsulorhexis quality in a training environment. Automated quality metrics measured by the augmented reality software p…
View article: National Consensus on the Assessment of Visual Function for Driving in Switzerland
National Consensus on the Assessment of Visual Function for Driving in Switzerland Open
Purpose To establish a national consensus on assessing visual function for fitness to drive in Switzerland. Methods The minimum medical requirements for visual function for fitness to drive are regulated by Swiss Federal Law, namely, by th…
View article: CRISPRa-mediated activation of genes associated with inherited retinal dystrophies in acutely isolated human cells for diagnostic purposes
CRISPRa-mediated activation of genes associated with inherited retinal dystrophies in acutely isolated human cells for diagnostic purposes Open
Many patients suffering from inherited diseases do not receive a genetic diagnosis and are therefore excluded as candidates for treatments, such as gene therapies. Analyzing disease-related gene transcripts from patient cells would improve…
View article: A novel multiplex RNAi therapy simultaneously targets <i>Hif1a</i> and <i>Hif2a</i> to defy retinal degeneration in two models of AMD
A novel multiplex RNAi therapy simultaneously targets <i>Hif1a</i> and <i>Hif2a</i> to defy retinal degeneration in two models of AMD Open
Age-related tissue changes lead to reduced oxygen delivery to photoreceptors and the retinal pigment epithelium (RPE), and contribute to the pathology of age-related macular degeneration (AMD). The implication of hypoxia-inducible factors …
View article: Sterile Intraocular Inflammation Associated With Faricimab
Sterile Intraocular Inflammation Associated With Faricimab Open
Importance Randomized clinical trials are conducted to establish both drug safety and efficacy. However, evidence of adverse events associated with these drugs in the clinical practice setting can be of value at generating hypotheses regar…
View article: Dynamics of Treatment Response to Faricimab for Diabetic Macular Edema
Dynamics of Treatment Response to Faricimab for Diabetic Macular Edema Open
This study analyzes the dynamics of short-term treatment response to the first intravitreal faricimab injection in eyes with diabetic macular edema (DME). This retrospective, single-center, clinical trial was conducted at the Department of…
View article: Long-Term Prevalence of Fungal Keratitis at a Swiss Tertiary Eye Clinic
Long-Term Prevalence of Fungal Keratitis at a Swiss Tertiary Eye Clinic Open
Fungal keratitis is a rare yet severe infection of the cornea. Fungal species distribution depends on the climate and socioeconomic status and can show regional variation. This retrospective single-center study was conducted at a tertiary …
View article: Assessing PCR-Positive Acanthamoeba Keratitis—A Retrospective Chart Review
Assessing PCR-Positive Acanthamoeba Keratitis—A Retrospective Chart Review Open
Ophthalmologists’ diagnostic and treatment competence in Acanthamoeba keratitis varies widely. This investigator-initiated, retrospective, single-center chart review examined the electronic patient files regarding PCR-positive Acanthamoeba…
View article: Real-World Weekly Efficacy Analysis of Faricimab in Patients with Age-Related Macular Degeneration
Real-World Weekly Efficacy Analysis of Faricimab in Patients with Age-Related Macular Degeneration Open
Objectives: This study entailed a weekly analysis of real-world data (RWD) on the safety and efficacy of intravitreal (IVT) faricimab in neovascular age-related macular degeneration (nAMD). Methods: A retrospective, single-centre clinical …
View article: Linear Interstitial Keratitis - Assessment of a Poorly Explored Clinical Entity
Linear Interstitial Keratitis - Assessment of a Poorly Explored Clinical Entity Open
Purpose: This retrospective, single-center case series included four patients clinically diagnosed with linear interstitial keratitis at the University Hospital Zurich, Switzerland.We aimed to expand the existing knowledge on this rare cli…
View article: Non-invasively assessing diabetic retinopathy using optical coherence tomography angiography
Non-invasively assessing diabetic retinopathy using optical coherence tomography angiography Open
A 29-year-old woman was referred to our ophthalmology department with a poorly controlled diabetes mellitus type 1. The patient reported gradual vision impairment over three years and poor adherence to anti-diabetic medication, suffering f…
View article: Detection of <i>Scedosporium</i> spp.: Colonizer or pathogen? A retrospective analysis of clinical significance and management in a large tertiary center
Detection of <i>Scedosporium</i> spp.: Colonizer or pathogen? A retrospective analysis of clinical significance and management in a large tertiary center Open
Infections with Scedosporium spp. are emerging in the past two decades and are associated with a high mortality rate. Microbiological detection can be associated with either colonization or infection. Evolution from colonization into infec…
View article: Sectoral Heterochromia
Sectoral Heterochromia Open
A 43-year-old man was found to have multicolored irises. The iris of the right eye had a blue superior sector and a brown inferior sector, and the iris of the left eye had an inverse color pattern.
View article: Severe Complications after Corneal Collagen Cross-Linking (CXL)
Severe Complications after Corneal Collagen Cross-Linking (CXL) Open
Purpose To present a case series of rare and severe complications after corneal collagen cross-linking (CXL) of keratoconus patients. Methods Single-center descriptive case series covering the period of 2012 to 2022 at the Department of Op…
View article: Analysis of Optical Coherence Tomography (OCT) and Optical Coherence Tomography Angiography (OCTA) Parameters in Young Adults after SARS-CoV-2 Infection (COVID-19) Compared with Healthy Young Controls
Analysis of Optical Coherence Tomography (OCT) and Optical Coherence Tomography Angiography (OCTA) Parameters in Young Adults after SARS-CoV-2 Infection (COVID-19) Compared with Healthy Young Controls Open
Purpose: To compare retinal changes in young adults with previous SARS-CoV-2 infection with healthy young controls using optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA). Methods: This prospective sing…
View article: Smartphone Slit Lamp Imaging—Usability and Quality Assessment
Smartphone Slit Lamp Imaging—Usability and Quality Assessment Open
Purpose: To assess the usability and image quality of a smartphone adapter for direct slit lamp imaging. Methods: A single-center, prospective, clinical study conducted in the Department of Ophthalmology at the University Hospital Zurich, …
View article: Impaired ABCA1/ABCG1-mediated lipid efflux in the mouse retinal pigment epithelium (RPE) leads to retinal degeneration
Impaired ABCA1/ABCG1-mediated lipid efflux in the mouse retinal pigment epithelium (RPE) leads to retinal degeneration Open
Age-related macular degeneration (AMD) is a progressive disease of the retinal pigment epithelium (RPE) and the retina leading to loss of central vision. Polymorphisms in genes involved in lipid metabolism, including the ATP-binding casset…