Frank Fleischmann
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View article: Bridging Spectral Gaps: Cross-Device Model Generalization in Blood-Based Infrared Spectroscopy
Bridging Spectral Gaps: Cross-Device Model Generalization in Blood-Based Infrared Spectroscopy Open
This paper presents a solution to the challenge of cross-device model generalization in blood-based infrared spectroscopy. As infrared spectroscopy becomes increasingly popular for analyzing human blood, ensuring that machine learning mode…
View article: Electric-Field Molecular Fingerprinting to Probe Cancer
Electric-Field Molecular Fingerprinting to Probe Cancer Open
Human biofluids serve as indicators of various physiological states, and recent advances in molecular profiling technologies hold great potential for enhancing clinical diagnostics. Leveraging recent developments in laser-based electric-fi…
View article: The Perils of Molecular Interpretations from Vibrational Spectra of Complex Samples
The Perils of Molecular Interpretations from Vibrational Spectra of Complex Samples Open
Vibrational spectroscopy is a widely used technique for chemical characterizations across various analytical sciences. Its applications are increasingly extending to the analysis of complex samples such as biofluids, providing high‐through…
View article: CODI: Enhancing machine learning-based molecular profiling through contextual out-of-distribution integration
CODI: Enhancing machine learning-based molecular profiling through contextual out-of-distribution integration Open
Molecular analytics increasingly utilize machine learning (ML) for predictive modeling based on data acquired through molecular profiling technologies. However, developing robust models that accurately capture physiological phenotypes is c…
View article: Assessing lung cancer progression and survival with infrared spectroscopy of blood serum
Assessing lung cancer progression and survival with infrared spectroscopy of blood serum Open
Infrared molecular fingerprinting has been identified as a new minimally invasive technological tool for disease diagnosis. While the utility of cross-molecular infrared fingerprints of serum and plasma for in vitro cancer diagnostics has …
View article: Plasma infrared fingerprinting with machine learning enables single-measurement multi-phenotype health screening
Plasma infrared fingerprinting with machine learning enables single-measurement multi-phenotype health screening Open
Infrared spectroscopy is a powerful technique for probing the molecular profiles of complex biofluids, offering a promising avenue for high-throughput in vitro diagnostics. While several studies showcased its potential in detecting health …
View article: CODI: Enhancing machine learning-based molecular profiling through contextual out-of-distribution integration
CODI: Enhancing machine learning-based molecular profiling through contextual out-of-distribution integration Open
Molecular analytics increasingly utilize machine learning (ML) for predictive modeling based on data acquired through molecular profiling technologies. However, developing robust models that accurately capture physiological phenotypes is c…
View article: Probing Blood Plasma Protein Glycosylation with Infrared Spectroscopy
Probing Blood Plasma Protein Glycosylation with Infrared Spectroscopy Open
The health state of an individual is closely linked to the glycosylation patterns of his or her blood plasma proteins. However, obtaining this information requires cost- and time-efficient analytical methods. We put forward infrared spectr…
View article: Infrared molecular fingerprinting of blood-based liquid biopsies for the detection of cancer
Infrared molecular fingerprinting of blood-based liquid biopsies for the detection of cancer Open
Recent omics analyses of human biofluids provide opportunities to probe selected species of biomolecules for disease diagnostics. Fourier-transform infrared (FTIR) spectroscopy investigates the full repertoire of molecular species within a…
View article: Author response: Infrared molecular fingerprinting of blood-based liquid biopsies for the detection of cancer
Author response: Infrared molecular fingerprinting of blood-based liquid biopsies for the detection of cancer Open
Article Figures and data Abstract Introduction Results Discussion Methods Data availability References Decision letter Author response Article and author information Metrics Abstract Recent omics analyses of human biofluids provide opportu…
View article: Endogenous rhythmic growth in oak trees is regulated by internal clocks rather than resource availability
Endogenous rhythmic growth in oak trees is regulated by internal clocks rather than resource availability Open
Common oak trees display endogenous rhythmic growth with alternating shoot and root flushes. To explore the mechanisms involved, microcuttings of the Quercus robur L. clone DF159 were used for (13)C/(15)N labelling in combination with RNA …