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View article: Proposed <scp>EU NGT</scp> legislation in light of plant genetic variation
Proposed <span>EU NGT</span> legislation in light of plant genetic variation Open
Summary The European Commission (EC) proposal for New Genomic Techniques (NGTs) of July 2023 specifies that Category 1 NGT (NGT1) plants, which are considered equivalent to conventional plants, that is those obtainable by conventional plan…
View article: Plant genomic variation and its implications for proposed EU NGT legislation
Plant genomic variation and its implications for proposed EU NGT legislation Open
The European Commission proposal for New Genomic Techniques (NGTs) of July 2023 specifies that NGT1 plants, which are considered equivalent to conventional plants, may differ from the recipient or parental plant by no more than 20 insertio…
View article: Genome editing around the globe: An update on policies and perceptions
Genome editing around the globe: An update on policies and perceptions Open
A decade ago, the CRISPR/Cas system has been adapted for genome editing. Since then, hundreds of organisms have been altered using genome editing and discussions were raised on the regulatory status of genome edited organisms esp. crops. T…
View article: Heterologous Complementation of SPO11-1 and -2 Depends on the Splicing Pattern
Heterologous Complementation of SPO11-1 and -2 Depends on the Splicing Pattern Open
In the past, major findings in meiosis have been achieved, but questions towards the global understanding of meiosis remain concealed. In plants, one of these questions covers the need for two diverse meiotic active SPO11 proteins. In Arab…
View article: Policies and Governance for Plant Genome Editing
Policies and Governance for Plant Genome Editing Open
Genome editing and modification techniques enable breeders to create single point mutations and to insert or delete new DNA sequences at a specific location in the plant genome thus for the first time making possible the precise modulation…
View article: Which Factors Affect the Occurrence of Off-Target Effects Caused by the Use of CRISPR/Cas: A Systematic Review in Plants
Which Factors Affect the Occurrence of Off-Target Effects Caused by the Use of CRISPR/Cas: A Systematic Review in Plants Open
CRISPR/Cas enables a targeted modification of DNA sequences. Despite their ease and efficient use, one limitation is the potential occurrence of associated off-target effects. This systematic review aims to answer the following research qu…
View article: Genome Edited Crops Touch the Market: A View on the Global Development and Regulatory Environment
Genome Edited Crops Touch the Market: A View on the Global Development and Regulatory Environment Open
Products of genome editing as the most promising "New Plant Breeding Technology" (NPBT) have made the transition from the lab to the market in a short time. Globally, research activities employing genome editing are constantly expanding an…
View article: Questions Regarding the Implementation of EU Mutagenesis Ruling in France
Questions Regarding the Implementation of EU Mutagenesis Ruling in France Open
The European Commission has asked EU Member States for comments on a French law notification demanding plant varieties produced with the help of in vitro mutagenesis have to be eliminated from the national catalog of approved varieties bec…
View article: Mapping of plant SynBio developments in the agri‐food sector
Mapping of plant SynBio developments in the agri‐food sector Open
The European Commission (EC)requested the European Food and Safety Authority (EFSA) for an opinion on genetically modified organisms for agri-food uses and developed through synthetic biology (SynBio) and their implications for risk assess…
View article: Additional file 4 of What is the available evidence for the range of applications of genome-editing as a new tool for plant trait modification and the potential occurrence of associated off-target effects: a systematic map
Additional file 4 of What is the available evidence for the range of applications of genome-editing as a new tool for plant trait modification and the potential occurrence of associated off-target effects: a systematic map Open
Additional file 4. List of articles excluded at full text assessment with the reason for exclusion.
View article: Additional file 2 of What is the available evidence for the range of applications of genome-editing as a new tool for plant trait modification and the potential occurrence of associated off-target effects: a systematic map
Additional file 2 of What is the available evidence for the range of applications of genome-editing as a new tool for plant trait modification and the potential occurrence of associated off-target effects: a systematic map Open
Additional file 2. List of peer-reviewed and grey literature sources searched.
View article: Additional file 7 of What is the available evidence for the range of applications of genome-editing as a new tool for plant trait modification and the potential occurrence of associated off-target effects: a systematic map
Additional file 7 of What is the available evidence for the range of applications of genome-editing as a new tool for plant trait modification and the potential occurrence of associated off-target effects: a systematic map Open
Additional file 7. ROSES Reporting Form.
View article: Additional file 5 of What is the available evidence for the range of applications of genome-editing as a new tool for plant trait modification and the potential occurrence of associated off-target effects: a systematic map
Additional file 5 of What is the available evidence for the range of applications of genome-editing as a new tool for plant trait modification and the potential occurrence of associated off-target effects: a systematic map Open
Additional file 5. List of relevant studies and the systematic map database to answer secondary question 1.
View article: Additional file 3 of What is the available evidence for the range of applications of genome-editing as a new tool for plant trait modification and the potential occurrence of associated off-target effects: a systematic map
Additional file 3 of What is the available evidence for the range of applications of genome-editing as a new tool for plant trait modification and the potential occurrence of associated off-target effects: a systematic map Open
Additional file 3. List of un-retrievable articles.
View article: Additional file 6 of What is the available evidence for the range of applications of genome-editing as a new tool for plant trait modification and the potential occurrence of associated off-target effects: a systematic map
Additional file 6 of What is the available evidence for the range of applications of genome-editing as a new tool for plant trait modification and the potential occurrence of associated off-target effects: a systematic map Open
Additional file 6. List of relevant studies and the systematic map database to answer secondary question 2.
View article: Detection and Identification of Genome Editing in Plants: Challenges and Opportunities
Detection and Identification of Genome Editing in Plants: Challenges and Opportunities Open
Conventional genetic engineering techniques generate modifications in the genome via stable integration of DNA elements which do not occur naturally in this combination. Therefore, the resulting organisms and (most) products thereof can un…
View article: Risk Assessment and Regulation of Plants Modified by Modern Biotechniques: Current Status and Future Challenges
Risk Assessment and Regulation of Plants Modified by Modern Biotechniques: Current Status and Future Challenges Open
This review describes the current status and future challenges of risk assessment and regulation of plants modified by modern biotechniques, namely genetic engineering and genome editing. It provides a general overview of the biosafety and…
View article: New Phenotypes of Potato Co-induced by Mismatch Repair Deficiency and Somatic Hybridization
New Phenotypes of Potato Co-induced by Mismatch Repair Deficiency and Somatic Hybridization Open
As plants are sessile they need a very efficient system for repairing damage done by external or internal mutagens to their DNA. Mismatch repair (MMR) is one of the systems that maintain genome integrity and prevent homeologous recombinati…
View article: MOESM6 of What is the available evidence for the range of applications of genome-editing as a new tool for plant trait modification and the potential occurrence of associated off-target effects: a systematic map
MOESM6 of What is the available evidence for the range of applications of genome-editing as a new tool for plant trait modification and the potential occurrence of associated off-target effects: a systematic map Open
Additional file 6. List of relevant studies and the systematic map database to answer secondary question 2.
View article: MOESM7 of What is the available evidence for the range of applications of genome-editing as a new tool for plant trait modification and the potential occurrence of associated off-target effects: a systematic map
MOESM7 of What is the available evidence for the range of applications of genome-editing as a new tool for plant trait modification and the potential occurrence of associated off-target effects: a systematic map Open
Additional file 7. ROSES Reporting Form.
View article: MOESM5 of What is the available evidence for the range of applications of genome-editing as a new tool for plant trait modification and the potential occurrence of associated off-target effects: a systematic map
MOESM5 of What is the available evidence for the range of applications of genome-editing as a new tool for plant trait modification and the potential occurrence of associated off-target effects: a systematic map Open
Additional file 5. List of relevant studies and the systematic map database to answer secondary question 1.
View article: MOESM3 of What is the available evidence for the range of applications of genome-editing as a new tool for plant trait modification and the potential occurrence of associated off-target effects: a systematic map
MOESM3 of What is the available evidence for the range of applications of genome-editing as a new tool for plant trait modification and the potential occurrence of associated off-target effects: a systematic map Open
Additional file 3. List of un-retrievable articles.
View article: MOESM4 of What is the available evidence for the range of applications of genome-editing as a new tool for plant trait modification and the potential occurrence of associated off-target effects: a systematic map
MOESM4 of What is the available evidence for the range of applications of genome-editing as a new tool for plant trait modification and the potential occurrence of associated off-target effects: a systematic map Open
Additional file 4. List of articles excluded at full text assessment with the reason for exclusion.
View article: MOESM2 of What is the available evidence for the range of applications of genome-editing as a new tool for plant trait modification and the potential occurrence of associated off-target effects: a systematic map
MOESM2 of What is the available evidence for the range of applications of genome-editing as a new tool for plant trait modification and the potential occurrence of associated off-target effects: a systematic map Open
Additional file 2. List of peer-reviewed and grey literature sources searched.
View article: The topoisomerase 3α zinc-finger domain T1 of Arabidopsis thaliana is required for targeting the enzyme activity to Holliday junction-like DNA repair intermediates
The topoisomerase 3α zinc-finger domain T1 of Arabidopsis thaliana is required for targeting the enzyme activity to Holliday junction-like DNA repair intermediates Open
Topoisomerase 3α, a class I topoisomerase, consists of a TOPRIM domain, an active centre and a variable number of zinc-finger domains (ZFDs) at the C-terminus, in multicellular organisms. Whereas the functions of the TOPRIM domain and the …
View article: What is the available evidence for the application of genome editing as a new tool for plant trait modification and the potential occurrence of associated off-target effects: a systematic map protocol
What is the available evidence for the application of genome editing as a new tool for plant trait modification and the potential occurrence of associated off-target effects: a systematic map protocol Open
Background Plant breeding is a developing process and breeding methods have continuously evolved over time. In recent years, genome editing techniques such as clustered regularly interspaced short palindromic repeats/CRISPR associated prot…
View article: Combining RNA-seq data and homology-based gene prediction for plants, animals and fungi
Combining RNA-seq data and homology-based gene prediction for plants, animals and fungi Open
GeMoMa might be of great utility for annotating newly sequenced genomes but also for finding homologs of a specific gene or gene family. GeMoMa has been published under GNU GPL3 and is freely available at http://www.jstacs.de/index.php/GeM…
View article: RecQ Helicases Function in Development, DNA Repair, and Gene Targeting in <i>Physcomitrella patens</i>
RecQ Helicases Function in Development, DNA Repair, and Gene Targeting in <i>Physcomitrella patens</i> Open
RecQ DNA helicases are genome surveillance proteins found in all kingdoms of life. They are characterized best in humans, as mutations in RecQ genes lead to developmental abnormalities and diseases. To better understand RecQ functions in p…