Frank M. Sacks
YOU?
Author Swipe
View article: Effect of weight loss through dietary interventions on cardiometabolic health in older adults
Effect of weight loss through dietary interventions on cardiometabolic health in older adults Open
NCT02817074.
View article: Effect modifiers of the MIND diet for cognition in older adults: The MIND diet trial
Effect modifiers of the MIND diet for cognition in older adults: The MIND diet trial Open
INTRODUCTION We examined whether participant characteristics, including sociodemographics, APOE ε4 allele, lifestyle factors, and cardiovascular risk factors, modified the effect of the Mediterranean–Dietary Approach to Systolic Hypertensi…
View article: Corrigendum to “The Dietary Biomarkers Development Consortium: An Initiative for Discovery and Validation of Dietary Biomarkers for Precision Nutrition. [Current Developments in Nutrition, Volume 9, Issue 5, May 2025, 107435]”
Corrigendum to “The Dietary Biomarkers Development Consortium: An Initiative for Discovery and Validation of Dietary Biomarkers for Precision Nutrition. [Current Developments in Nutrition, Volume 9, Issue 5, May 2025, 107435]” Open
[This corrects the article DOI: 10.1016/j.cdnut.2025.107435.].
View article: The Dietary Biomarkers Development Consortium: An Initiative for Discovery and Validation of Dietary Biomarkers for Precision Nutrition
The Dietary Biomarkers Development Consortium: An Initiative for Discovery and Validation of Dietary Biomarkers for Precision Nutrition Open
View article: Machine-learning approaches to predict individualized treatment effect using a randomized controlled trial
Machine-learning approaches to predict individualized treatment effect using a randomized controlled trial Open
View article: Higher plasma antioxidant nutrient levels associated with slower cognitive decline among individuals with APOE‐e4: an investigation of the MIND trial
Higher plasma antioxidant nutrient levels associated with slower cognitive decline among individuals with APOE‐e4: an investigation of the MIND trial Open
Background Observational studies have shown a protective association between antioxidant nutrients and lower risk of Alzheimer’s disease. Results from dietary intervention trials remain inconclusive. The effect of APOE‐e4, the strongest ri…
View article: Dietary intervention, biomarkers of brain pathology and neurodegeneration, and cognition: The MIND Trial Study
Dietary intervention, biomarkers of brain pathology and neurodegeneration, and cognition: The MIND Trial Study Open
Background Plasma levels of phosphorylated tau (pTau‐181), neurofilament light chain (NfL), and glial fibrillary acidic protein (GFAP) as biomarkers of brain pathology and neurodegeneration have been associated with cognition and Alzheimer…
View article: Effect of intentional weight loss through dietary intervention on cognition: The MIND Trial Study
Effect of intentional weight loss through dietary intervention on cognition: The MIND Trial Study Open
Background With the increasing prevalence of obesity and its negative consequences on health, weight management has emerged as a priority for public health. We conducted a study to investigate the association of intentional weight loss thr…
View article: Metabolomics Analysis of the MIND Study Informs about Metabolic Benefit and Heterogeneity among Individuals‐ A Precision Medicine Approach for Diet Interventions
Metabolomics Analysis of the MIND Study Informs about Metabolic Benefit and Heterogeneity among Individuals‐ A Precision Medicine Approach for Diet Interventions Open
Background Metabolomics captures net influences of exposome, diet, gut microbiome, and genome, informing about individuality and how we respond to interventions. Applications of metabolomics in pharmacology are starting to enable a Systems…
View article: Apolipoprotein A-I infusions and cardiovascular outcomes in acute myocardial infarction according to baseline LDL-cholesterol levels: the AEGIS-II trial
Apolipoprotein A-I infusions and cardiovascular outcomes in acute myocardial infarction according to baseline LDL-cholesterol levels: the AEGIS-II trial Open
Background and Aims In the AEGIS-II trial (NCT03473223), CSL112, a human apolipoprotein A1 derived from plasma that increases cholesterol efflux capacity, did not significantly reduce the risk of the primary endpoint through 90 days vs. pl…
View article: Peripheral inflammation is associated with brain atrophy and cognitive decline linked to mild cognitive impairment and Alzheimer’s disease
Peripheral inflammation is associated with brain atrophy and cognitive decline linked to mild cognitive impairment and Alzheimer’s disease Open
View article: Is There an Ideal Diet? Some Insights from the POUNDS Lost Study
Is There an Ideal Diet? Some Insights from the POUNDS Lost Study Open
Diets for weight loss have a long history but an ideal one has not yet been clearly identified. To compare low-fat and lower carbohydrate diets, we designed The Preventing Overweight by Novel Dietary Strategies (POUNDS) Lost study. This is…
View article: Effect of Reconstituted Human Apolipoprotein A-I on Recurrent Ischemic Events in Survivors of Acute MI
Effect of Reconstituted Human Apolipoprotein A-I on Recurrent Ischemic Events in Survivors of Acute MI Open
Although CSL112 did not significantly reduce the occurrence of the primary study endpoints, patients treated with CSL112 infusions had numerically lower rates of CV death and MI, type-1 MI, and stent thrombosis-related MI compared with pla…
View article: Changes in bile acid subtypes and improvements in lipid metabolism and atherosclerotic cardiovascular disease risk: the Preventing Overweight Using Novel Dietary Strategies (POUNDS Lost) trial
Changes in bile acid subtypes and improvements in lipid metabolism and atherosclerotic cardiovascular disease risk: the Preventing Overweight Using Novel Dietary Strategies (POUNDS Lost) trial Open
Decreases in distinct BA subtypes were associated with improved lipid profiles and ASCVD risk estimates, highlighting the importance of changes in circulating BA subtypes as significant factors linked to improved lipid metabolism and ASCVD…
View article: Primary prevention of cognitive decline in older individuals with the MIND diet
Primary prevention of cognitive decline in older individuals with the MIND diet Open
Background The Mediterranean‐DASH Intervention for Neurodegenerative Delay (MIND) diet is a hybrid of the Mediterranean and DASH diets, with added foods designed to target brain health. Observational studies demonstrate inverse relations w…
View article: Understanding HDL Metabolism and Biology Through In Vivo Tracer Kinetics
Understanding HDL Metabolism and Biology Through In Vivo Tracer Kinetics Open
HDL (high-density lipoprotein), owing to its high protein content and small size, is the densest circulating lipoprotein. In contrast to lipid-laden VLDL (very-low-density lipoprotein) and LDL (low-density lipoprotein) that promote atheros…
View article: Proteomic Determinants of Variation in Cholesterol Efflux: Observations from the Dallas Heart Study
Proteomic Determinants of Variation in Cholesterol Efflux: Observations from the Dallas Heart Study Open
High-density lipoproteins (HDLs) are promising targets for predicting and treating atherosclerotic cardiovascular disease (ASCVD), as they mediate removal of excess cholesterol from lipid-laden macrophages that accumulate in the vasculatur…
View article: Red meat intake and risk of type 2 diabetes in a prospective cohort study of United States females and males
Red meat intake and risk of type 2 diabetes in a prospective cohort study of United States females and males Open
View article: Circular-SWAT for deep learning based diagnostic classification of Alzheimer's disease: application to metabolome data
Circular-SWAT for deep learning based diagnostic classification of Alzheimer's disease: application to metabolome data Open
The specific funding of this article is provided in the acknowledgements section.
View article: Estimated Glomerular Filtration Rate, Albuminuria, and Adverse Outcomes
Estimated Glomerular Filtration Rate, Albuminuria, and Adverse Outcomes Open
Importance Chronic kidney disease (low estimated glomerular filtration rate [eGFR] or albuminuria) affects approximately 14% of adults in the US. Objective To evaluate associations of lower eGFR based on creatinine alone, lower eGFR based …
View article: FRI074 Rise In Fasting Ghrelin Level In Response To Weight Loss Predicts Future Weight Regain In The POUNDS LOST Trial
FRI074 Rise In Fasting Ghrelin Level In Response To Weight Loss Predicts Future Weight Regain In The POUNDS LOST Trial Open
Disclosure: J. Tong: None. Y. Heianza: None. E.A. Schur: None. F. Sacks: None. L. Qi: None. E.J. Boyko: None. Weight loss maintenance is a challenging problem commonly encountered in obesity management. The biological mechanism for weight …
View article: DNA methylation at ABCG1 and long-term changes in adiposity and fat distribution in response to diet interventions: the POUNDS Lost trial
DNA methylation at ABCG1 and long-term changes in adiposity and fat distribution in response to diet interventions: the POUNDS Lost trial Open
Objective: To examine whether participants with different levels of diabetes-related DNA methylation at ABCG1 might respond differently to dietary weight-loss interventions with long-term changes in adiposity and body fat distribution. Res…
View article: DNA methylation at ABCG1 and long-term changes in adiposity and fat distribution in response to diet interventions: the POUNDS Lost trial
DNA methylation at ABCG1 and long-term changes in adiposity and fat distribution in response to diet interventions: the POUNDS Lost trial Open
Objective: To examine whether participants with different levels of diabetes-related DNA methylation at ABCG1 might respond differently to dietary weight-loss interventions with long-term changes in adiposity and body fat distribution. Res…
View article: DNA Methylation at<i>ABCG1</i>and Long-term Changes in Adiposity and Fat Distribution in Response to Dietary Interventions: The POUNDS Lost Trial
DNA Methylation at<i>ABCG1</i>and Long-term Changes in Adiposity and Fat Distribution in Response to Dietary Interventions: The POUNDS Lost Trial Open
OBJECTIVE To examine whether participants with different levels of diabetes-related DNA methylation at ABCG1 might respond differently to dietary weight loss interventions with long-term changes in adiposity and body fat distribution. RESE…
View article: Toward Precision Weight-Loss Dietary Interventions: Findings from the POUNDS Lost Trial
Toward Precision Weight-Loss Dietary Interventions: Findings from the POUNDS Lost Trial Open
The POUNDS Lost trial is a 2-year clinical trial testing the effects of dietary interventions on weight loss. This study included 811 adults with overweight or obesity who were randomized to one of four diets that contained either 15% or 2…
View article: Trial of the MIND Diet for Prevention of Cognitive Decline in Older Persons
Trial of the MIND Diet for Prevention of Cognitive Decline in Older Persons Open
Among cognitively unimpaired participants with a family history of dementia, changes in cognition and brain MRI outcomes from baseline to year 3 did not differ significantly between those who followed the MIND diet and those who followed t…
View article: P29-018-23 Red Meat Intake and Risk of Type 2 Diabetes in US Women and Men
P29-018-23 Red Meat Intake and Risk of Type 2 Diabetes in US Women and Men Open
View article: OR02-06-23 Carbohydrate Digestion-Related AMY1 Gene Copy Number Variations As Determinants of Novel Metabolomics Signatures Related to Type 2 Diabetes
OR02-06-23 Carbohydrate Digestion-Related AMY1 Gene Copy Number Variations As Determinants of Novel Metabolomics Signatures Related to Type 2 Diabetes Open
View article: OR24-06-23 Replacing Ultra-Processed Foods With Minimally Processed Foods Enhances 6-Month Weight Loss Among Participants in the POUNDS Lost Trial
OR24-06-23 Replacing Ultra-Processed Foods With Minimally Processed Foods Enhances 6-Month Weight Loss Among Participants in the POUNDS Lost Trial Open
View article: Dietary Effects on Monocyte Phenotypes in Subjects With Hypertriglyceridemia and Metabolic Syndrome
Dietary Effects on Monocyte Phenotypes in Subjects With Hypertriglyceridemia and Metabolic Syndrome Open
In patients with hypertriglyceridemia, a short-term low-saturated fat vs high-saturated fat diet induced lower plasma lipids and improved monocyte phenotypes. These findings highlight the role of diet fat content and composition for monocy…