Frank Marrone
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View article: Peptide Tethering: Pocket-Directed Fragment Screening for Peptidomimetic Inhibitor Discovery
Peptide Tethering: Pocket-Directed Fragment Screening for Peptidomimetic Inhibitor Discovery Open
Constrained peptides have proven to be a rich source of ligands for protein surfaces, but are often limited in their binding potency. Deployment of nonnatural side chains that access unoccupied crevices on the receptor surface offers a pot…
View article: Variation in predicted COVID‐19 risk among lemurs and lorises
Variation in predicted COVID‐19 risk among lemurs and lorises Open
The novel coronavirus SARS‐CoV‐2, which in humans leads to the disease COVID‐19, has caused global disruption and more than 2 million fatalities since it first emerged in late 2019. As we write, infection rates are at their highest point g…
View article: Variation in predicted COVID-19 risk among lemurs and lorises
Variation in predicted COVID-19 risk among lemurs and lorises Open
The novel coronavirus SARS-CoV-2, which in humans leads to the disease COVID-19, has caused global disruption and more than 1.5 million fatalities since it first emerged in late 2019. As we write, infection rates are currently at their hig…
View article: Comparative ACE2 variation and primate COVID-19 risk
Comparative ACE2 variation and primate COVID-19 risk Open
The emergence of SARS-CoV-2 has caused over a million human deaths and massive global disruption. The viral infection may also represent a threat to our closest living relatives, nonhuman primates. The contact surface of the host cell rece…
View article: Comparative ACE2 variation and primate COVID-19 risk
Comparative ACE2 variation and primate COVID-19 risk Open
The emergence of the novel coronavirus SARS-CoV-2, which in humans is highly infectious and leads to the potentially fatal disease COVID-19, has caused hundreds of thousands of deaths and huge global disruption. The viral infection may als…