Frank P. Dupuy
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View article: IL-10 driven memory T cell survival and Tfh differentiation promote HIV persistence
IL-10 driven memory T cell survival and Tfh differentiation promote HIV persistence Open
Summary Mechanisms regulating HIV persistence are complex and not well understood. Increased IL-10 levels were positively associated with HIV reservoir in blood and lymph nodes (LN) of treated HIV aviremic individuals. In LNs, B cells, reg…
View article: Follicular CD4 T Helper Cells As a Major HIV Reservoir Compartment: A Molecular Perspective
Follicular CD4 T Helper Cells As a Major HIV Reservoir Compartment: A Molecular Perspective Open
Effective antiretroviral therapy (ART) has prevented the progression to AIDS and reduced HIV-related morbidities and mortality for the majority of infected individuals. However, a lifelong administration of ART is necessary, placing an ino…