Frank Trudo
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View article: Pragmatic Evaluation of an Improvement Program for People Living With Modifiable High-Risk COPD Versus Usual Care: Protocol for the Cluster Randomized PREVAIL Trial
Pragmatic Evaluation of an Improvement Program for People Living With Modifiable High-Risk COPD Versus Usual Care: Protocol for the Cluster Randomized PREVAIL Trial Open
UK trial: ISRCTN15819828; US trial: NCT05306743.
View article: On-treatment clinical remission of severe asthma with real-world longer-term biologic use
On-treatment clinical remission of severe asthma with real-world longer-term biologic use Open
In a real-world cohort of patients with SA with longer-term biologic treatment, almost one-half achieved on-treatment clinical remission. With at least 1 year of biologic therapy, clinical remission is a feasible treatment goal in SA.
View article: Albuterol-budesonide rescue reduces progression from asthma deterioration to severe exacerbation
Albuterol-budesonide rescue reduces progression from asthma deterioration to severe exacerbation Open
No abstract available
View article: Discriminative Accuracy of the CAPTURE Tool for Identifying Chronic Obstructive Pulmonary Disease in US Primary Care Settings
Discriminative Accuracy of the CAPTURE Tool for Identifying Chronic Obstructive Pulmonary Disease in US Primary Care Settings Open
Importance Chronic obstructive pulmonary disease (COPD) is underdiagnosed in primary care. Objective To evaluate the operating characteristics of the CAPTURE (COPD Assessment in Primary Care To Identify Undiagnosed Respiratory Disease and …
View article: Clinical Remission With Biologic Use Among US Subspecialist-Treated Patients With Severe Asthma: Results From the CHRONICLE Study
Clinical Remission With Biologic Use Among US Subspecialist-Treated Patients With Severe Asthma: Results From the CHRONICLE Study Open
Rationale: There are limited real-world data regarding the proportion of patients with severe asthma (SA) who achieve clinical remission with biologic treatment. Methods: CHRONICLE is an observational study of subspecialist-treated adults …
View article: Long-Term Use of Maintenance Systemic Corticosteroids is Associated with Multiple Adverse Conditions in a Large, Real-World Cohort of US Adults with Severe Asthma
Long-Term Use of Maintenance Systemic Corticosteroids is Associated with Multiple Adverse Conditions in a Large, Real-World Cohort of US Adults with Severe Asthma Open
There is growing recognition of the adverse consequences of maintenance systemic corticosteroid (mSCS) therapy in severe asthma (SA). The objective of this study was to describe the prevalence of potential adverse effects of long-term mSCS…
View article: Differing perceptions of asthma control and treatment effectiveness by patients with severe asthma and treating subspecialists in the United States
Differing perceptions of asthma control and treatment effectiveness by patients with severe asthma and treating subspecialists in the United States Open
ClinicalTrials.gov Identifier: NCT03373045.
View article: CONQUEST Quality Standards: For the Collaboration on Quality Improvement Initiative for Achieving Excellence in Standards of COPD Care
CONQUEST Quality Standards: For the Collaboration on Quality Improvement Initiative for Achieving Excellence in Standards of COPD Care Open
The CONQUEST QS represent an important step in our aim to improve care for patients with COPD in primary and secondary care. They will help to transform the patient journey, by encouraging early intervention to identify, assess, optimally …
View article: Health-Related Quality of Life and Productivity Among US Patients with Severe Asthma
Health-Related Quality of Life and Productivity Among US Patients with Severe Asthma Open
ClinicalTrials.gov Identifier: NCT03373045.
View article: <p>Unreported and Overlooked: A Post Hoc Analysis of COPD Symptom-Related Attacks from the RISE Study</p>
Unreported and Overlooked: A Post Hoc Analysis of COPD Symptom-Related Attacks from the RISE Study Open
COPD symptom-related attacks are common and typically unreported. Importantly, these attacks can account for considerable morbidity and should not be regarded as "mild". Detection of such exacerbations may be valuable in identifying patien…
View article: Blood Eosinophil Count and Hospital Readmission in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Blood Eosinophil Count and Hospital Readmission in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease Open
Matthew J Hegewald,1,2 Benjamin D Horne,3,4 Frank Trudo,5 James L Kreindler,5 Yen Chung,5 Susan Rea,6 Denitza P Blagev1,2 1Pulmonary and Critical Care Medicine Division, Intermountain Medical Center, Murray, UT, USA; 2Pulmonary and Critica…
View article: <p>Blood Eosinophil Count and Hospital Readmission in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease</p>
Blood Eosinophil Count and Hospital Readmission in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease Open
Eosinophil counts in patients with COPD were not associated with a difference in 30-day all-cause readmissions. However, greater eosinophil counts were associated with increased risk of all-cause readmission at 90 days and 12 months and CO…
View article: <p>The CHRONICLE Study of US Adults with Subspecialist-Treated Severe Asthma: Objectives, Design, and Initial Results</p>
The CHRONICLE Study of US Adults with Subspecialist-Treated Severe Asthma: Objectives, Design, and Initial Results Open
CHRONICLE will provide high-quality provider- and patient-reported data from a large, real-world cohort of US adults with subspecialist-treated severe asthma.
View article: Biologic and maintenance systemic corticosteroid therapy among US subspecialist-treated patients with severe asthma
Biologic and maintenance systemic corticosteroid therapy among US subspecialist-treated patients with severe asthma Open
ClinicalTrials.gov Identifier: NCT03373045.
View article: An expert consensus framework for asthma remission as a treatment goal
An expert consensus framework for asthma remission as a treatment goal Open
With novel therapies in development, there is an opportunity to consider asthma remission as a treatment goal. In this Rostrum, we present a generalized framework for clinical and complete remission in asthma, on and off treatment, develop…
View article: <p>Clinical And Economic Burden Of Eosinophilic COPD In A Large Retrospective US Cohort</p>
Clinical And Economic Burden Of Eosinophilic COPD In A Large Retrospective US Cohort Open
COPD patients with EOS counts ≥220 cells/µL were more likely to have had moderate or severe exacerbations and greater cost of care than those with EOS <220 cells/µL.
View article: Benralizumab efficacy for patients with fixed airflow obstruction and severe, uncontrolled eosinophilic asthma
Benralizumab efficacy for patients with fixed airflow obstruction and severe, uncontrolled eosinophilic asthma Open
SIROCCO trial: NCT01928771 (URL: https://clinicaltrials.gov/ct2/show/NCT01928771) CALIMA trial: NCT01914757 (URL: https://clinicaltrials.gov/ct2/show/NCT01914757).