Frank van Drogen
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View article: Positive feedback induces switch between distributive and processive phosphorylation of Hog1
Positive feedback induces switch between distributive and processive phosphorylation of Hog1 Open
View article: Phosphorylation‐linked complex profiling identifies assemblies required for Hippo signal integration
Phosphorylation‐linked complex profiling identifies assemblies required for Hippo signal integration Open
View article: Crosstalk and spatiotemporal regulation between stress-induced MAP kinase pathways and pheromone signaling in budding yeast
Crosstalk and spatiotemporal regulation between stress-induced MAP kinase pathways and pheromone signaling in budding yeast Open
Budding yeast, Saccharomyces cerevisiae, has been widely used as a model system to study cellular signaling in response to internal and external cues. Yeast was among the first organisms in which the architecture, feedback mechanism…
View article: Mechanical stress impairs pheromone signaling via Pkc1-mediated regulation of the MAPK scaffold Ste5
Mechanical stress impairs pheromone signaling via Pkc1-mediated regulation of the MAPK scaffold Ste5 Open
Cells continuously adapt cellular processes by integrating external and internal signals. In yeast, multiple stress signals regulate pheromone signaling to prevent mating under unfavorable conditions. However, the underlying crosstalk mech…
View article: Protein kinase C and calcineurin cooperatively mediate cell survival under compressive mechanical stress
Protein kinase C and calcineurin cooperatively mediate cell survival under compressive mechanical stress Open
Significance Cells are constantly exposed to a variety of mechanical cues, and respond by activating conserved signaling pathways that modulate their profiliation and intracellular organization. For instance, cells in solid tumors experien…