Explanipedia

Measuring alarm fatigue in intensive care units: translation and validation of the Charité Alarm Fatigue Questionnaire: a multi-centre study Open

Verona C A Gerardu, Lina Mosch, Carla Kloeze, Jip W T M de Kok, I Herold , et al. · 2025

Comparison of regional lung mechanics using electrical impedance tomography in mechanically ventilated COVID-19 vs pre-pandemic patients: A retrospective study Open

Eda Aydeniz, Serge J Heines, Frank van Rosmalen, Iwan C.C. van der Horst, Bas C. T. van Bussel , et al. · 2025

Accuracy between ICU admission and discharge diagnoses in non-survivors: A retrospective cohort study Open

Hannah H.M. Hulsewé, Thom Wilbers, Frank van Rosmalen, Jasper van Bommel, Sylvia Brinkman , et al. · 2025

Differences between ICU admission and discharge diagnoses occur frequently, this leads to only a small discrepancy in the overall predicted mortality of deceased ICU patients.

Post-COVID microvascular dysfunction in hospitalized COVID-19 survivors is associated with acute disease severity and persistent cognitive complaints Open

Noa van der Knaap, Simona Klinkhammer, Alida A. Postma, Johanna M. A. Visser‐Meily, Janneke Horn , et al. · 2025

Significantly more widespread post-COVID cerebral microvascular dysfunction was found in COVID-19 ICU compared to general ward survivors. Post-COVID microvascular dysfunction in the NAWM may be due to more severe cerebral tissue hypoxia at…

Exploration of the plasma proteomic profile of patients at risk of thromboembolic events Open

Eva R. Smit, Iris C. Kreft, Eleonora Camilleri, J. Burggraaf, Nienke van Rein , et al. · 2025

Although VKA treatment-specific and disease-specific signatures were captured, our study highlights that the challenges of discovering biomarkers in patients at risk of thromboembolic events lie in the heterogeneity of individual plasma pr…

The Maastricht Intensive Care COVID Cohort: A Critical Appraisal of the Predefined Research Questions Open

Marieke S. J. N. Wintjens, Eda Aydeniz, Frank van Rosmalen, Rob Driessen, Anne‐Marije Hulshof , et al. · 2025

IMPORTANCE: A review of the study processes and protocols afterward by the researchers themselves is scarce. OBJECTIVES: The present study aimed to evaluate the study design and the process of data collection of the Maastricht Intensive Ca…

More self‐efficacy is associated with longitudinally higher health‐related quality of life in mechanically ventilated COVID‐19 ICU survivors: The prospective MaastrICCht cohort Open

Laura M. Tiels, Marieke S. J. N. Wintjens, Sophie Waardenburg, Frank van Rosmalen, Sander M. J. van Kuijk , et al. · 2025

Background More self‐efficacy leads to greater confidence in one's ability to perform actions to achieve treatment goals. Therefore, self‐efficacy may affect patient recovery and health‐related quality of life (HRQoL) after ICU discharge. …

Monitoring of myocardial injury by serial measurements of QRS area and T area: The MaastrICCht cohort Open

Mohammed A. Ghossein, Jip W T M de Kok, Frederieke Eerenberg, Frank van Rosmalen, R. Boereboom , et al. · 2024

Background Manually derived electrocardiographic (ECG) parameters were not associated with mortality in mechanically ventilated COVID‐19 patients in earlier studies, while increased high‐sensitivity cardiac troponin‐T (hs‐cTnT) and N‐termi…

Modeling creatine-kinase MB concentrations following coronary artery bypass grafting Open

Jamie Romeo, Pieter A. Vriesendorp, Kim Gerritsen, Musafir Nader, Edris A.F. Mahtab , et al. · 2024

Corrigendum to Table 0; documenting the steps to go from clinical database to research dataset Journal of Clinical Epidemiology Volume 170 (2024) 111342 Open

Jip W T M de Kok, Bas C. T. van Bussel, Ronny M. Schnabel, Thijs T. W. van Herpt, Rob Driessen , et al. · 2024

The incidence of neurological complications in mechanically ventilated COVID-19 ICU patients: An observational single-center cohort study in three COVID-19 periods Open

Noa van der Knaap, Fleur de Vreeze, Frank van Rosmalen, Marieke S. J. N. Wintjens, Susanne van Santen , et al. · 2024

The laboratory parameters-derived CoLab score as an indicator of the host response in ICU COVID-19 patients decreases over time: a prospective cohort study Open

Tom Schoenmakers, Mathie P.G. Leers, Stefan H.M. Gorissen, Inge H. M. van Loo, Frank van Rosmalen , et al. · 2024

The CoLab score was developed and externally validated to rule out COVID-19 among suspected patients presenting at the emergency department. We hypothesized a within-patient decrease in the CoLab score over time in an intensive care unit (…

Table 0; documenting the steps to go from clinical database to research dataset Open

Jip W T M de Kok, Bas C. T. van Bussel, Ronny M. Schnabel, Thijs T. W. van Herpt, Rob Driessen , et al. · 2024

The CoLab score is associated with SARS-CoV-2 viral load during admission in individuals admitted to the intensive care unit: the CoLaIC cohort study Open

Tom Schoenmakers, Mathie P.G. Leers, Ruben Deneer, Frank van Rosmalen, Stefan H.M. Gorissen , et al. · 2024

Objectives The present study examines the temporal association between the changes in SARS-CoV-2 viral load during infection and whether the CoLab-score can facilitate de-isolation. Methods Nasal swabs and blood samples were collected from…

The association between coronary artery calcification and vectorcardiography in mechanically ventilated COVID-19 patients: the Maastricht Intensive Care COVID cohort Open

Eda Aydeniz, Frank van Rosmalen, Jip W T M de Kok, Bibi Martens, Alma M.A. Mingels , et al. · 2024

Deep embedded clustering generalisability and adaptation for integrating mixed datatypes: two critical care cohorts Open

Jip W T M de Kok, Frank van Rosmalen, Jacqueline Koeze, Frederik Keus, Sander M. J. van Kuijk , et al. · 2024

Accuracy between Icu Admission and Discharge Diagnoses in Non-Survivors: A Retrospective Cohort Study Open

Hannah H.M. Hulsewé, Thom Wilbers, Frank van Rosmalen, Jasper van Bommel, Sylvia Brinkman , et al. · 2024

Rotational thromboelastometry as a biomarker for mortality — The Maastricht Intensive Care COVID cohort Open

Anne‐Marije Hulshof, Linda Nab, Frank van Rosmalen, Jip de Kok, Mark M. G. Mulder , et al. · 2023

ROTEM measurements demonstrate a further increase of hypercoagulability and (hypo)fibrinolysis parameters in non-survivors throughout ICU admission. Furthermore, prolonged CT at intubation was associated with higher 45-day ICU mortality.

Higher levels of circulating desphospho-uncarboxylated matrix Gla protein over time are associated with worse survival: the prospective Maastricht Intensive Care COVID cohort Open

Mark M. G. Mulder, Joep Schellens, Jan-Willem E. M. Sels, Frank van Rosmalen, Anne‐Marije Hulshof , et al. · 2023

Serial electrical impedance tomography course in different treatment groups; The MaastrICCht cohort Open

Eda Aydeniz, Bas C. T. van Bussel, S. de Jongh, Joep Schellens, Serge J Heines , et al. · 2023

Hyperglycemia and glucose variability are associated with worse survival in mechanically ventilated COVID-19 patients: the prospective Maastricht Intensive Care Covid Cohort Open

Thijs T. W. van Herpt, Frank van Rosmalen, Hendrica P.M.G. Hulsewé, Anouk N.A. van der Horst‐Schrivers, Mariëlle Driessen , et al. · 2023

Background Data on hyperglycemia and glucose variability in relation to diabetes mellitus, either known or unknown in ICU-setting in COVID-19, are scarce. We prospectively studied daily glucose variables and mortality in strata of diabetes…

Deep embedded clustering generalisability and adaptation for mixed datatypes: two critical care cohorts Open

Jip de Kok, Frank van Rosmalen, Jacqueline Koeze, Frederik Keus, Sander M. J. van Kuijk , et al. · 2023

We propose X-DEC, a novel deep clustering technique that can integrate mixed datatypes (in this study numerical and categorical variables). Deep Embedded Clustering (DEC) is a promising technique capable of managing extensive sets of varia…

Regional variability in intracerebral properties of NREM to REM sleep transitions in humans Open

Laure Peter‐Derex, Nicolás von Ellenrieder, Frank van Rosmalen, Jeffery A. Hall, François Dubeau , et al. · 2023

Transitions between wake and sleep states show a progressive pattern underpinned by local sleep regulation. In contrast, little evidence is available on non–rapid eye movement (NREM) to rapid eye movement (REM) sleep boundaries, considered…

Transition from NREM to REM sleep Open

Laure Peter‐Derex, Nicolás von Ellenrieder, Frank van Rosmalen, Jeffrey A. Hall, François Dubeau , et al. · 2023

This is the data and matlab code to accompany the paper entitled "Which region enters REM sleep first: Intracerebral properties of NREM to REM sleep transitions in human sleep," by L Peter-Derex, N von Ellenrieder, F van Rosmalen, J Hall, …

Transition from NREM to REM sleep Open

Laure Peter‐Derex, Nicolás von Ellenrieder, Frank van Rosmalen, Jeffrey A. Hall, François Dubeau , et al. · 2023

This is the data and matlab code to accompany the paper entitled "Which region enters REM sleep first: Intracerebral properties of NREM to REM sleep transitions in human sleep," by L Peter-Derex, N von Ellenrieder, F van Rosmalen, J Hall, …

Validating a clinical laboratory parameter-based deisolation algorithm for patients with COVID-19 in the intensive care unit using viability PCR: the CoLaIC multicentre cohort study protocol Open

Tom Schoenmakers, Bas C. T. van Bussel, Stefan H.M. Gorissen, Inge H. M. van Loo, Frank van Rosmalen , et al. · 2023

Introduction To investigate whether biochemical and haematological changes due to the patient’s host response (CoLab algorithm) in combination with a SARS-CoV-2 viability PCR (v-PCR) can be used to determine when a patient with COVID-19 is…

Hyperglycemia and glucose variability are associated with worse survival in mechanically ventilated COVID-19 patients: the prospective Maastricht Intensive Care Covid Cohort Open

Thijs T. W. van Herpt, Frank van Rosmalen, Hendrica P.M.G. Hulsewé, Anouk N.A. van der Horst‐Schrivers, Mariëlle Driessen , et al. · 2023

Data on hyperglycemia and glucose variability in relation to diabetes mellitus, either known or unknown in ICU-setting in COVID-19, are scarce. We prospectively studied daily glucose variables and mortality in strata of diabetes mellitus a…

Differential Fibrinolysis Profile in COVID-19 Patients Dependent on Immunosuppressive Treatment Regimen: A Nested Case-Control Study Open

Magdolna Nagy, Joep Schellens, Anne‐Marije Hulshof, Frank van Rosmalen, René van Oerle , et al. · 2022

Introduction: Severe coronavirus disease 2019 (COVID-19) is associated with thrombotic complications, despite prophylactic and therapeutic anticoagulation. The disease course of critically ill COVID-19 patients has been characterized by se…

Pulmonary pathophysiology development of COVID-19 assessed by serial Electrical Impedance Tomography in the MaastrICCht cohort Open

Serge J Heines, Bas C. T. van Bussel, Melanie J. Acampo-de Jong, Frank C. Bennis, Rob J. J. van Gassel , et al. · 2022

Serial Assessment of Myocardial Injury Markers in Mechanically Ventilated Patients With SARS-CoV-2 (from the Prospective MaastrICCht Cohort) Open

Mohammed A. Ghossein, Rob Driessen, Frank van Rosmalen, Jan-Willem E. M. Sels, Thijs Delnoij , et al. · 2022

Frank van Rosmalen YOU? Author Swipe