Fransisca Sumardy
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View article: Differential regulation of BAX and BAK apoptotic activity revealed by small molecules
Differential regulation of BAX and BAK apoptotic activity revealed by small molecules Open
Defective apoptosis mediated by B cell lymphoma 2 antagonist/killer (BAK) or B cell lymphoma 2–associated X protein (BAX) underlies various pathologies including autoimmune and degenerative conditions. On mitochondria, voltage-dependent an…
View article: Improved drug target deconvolution with PISA‐DIA using an extended, overlapping temperature gradient
Improved drug target deconvolution with PISA‐DIA using an extended, overlapping temperature gradient Open
Thermal proteome profiling (TPP) is a powerful tool for drug target deconvolution. Recently, data‐independent acquisition mass spectrometry (DIA‐MS) approaches have demonstrated significant improvements to depth and missingness in proteome…
View article: Key residues in the VDAC2-BAK complex can be targeted to modulate apoptosis
Key residues in the VDAC2-BAK complex can be targeted to modulate apoptosis Open
BAK and BAX execute intrinsic apoptosis by permeabilising the mitochondrial outer membrane. Their activity is regulated through interactions with pro-survival BCL-2 family proteins and with non-BCL-2 proteins including the mitochondrial ch…
View article: Molecular definition of the BAK:VDAC2 interaction as a target to manipulate apoptosis
Molecular definition of the BAK:VDAC2 interaction as a target to manipulate apoptosis Open
BAK and BAX execute intrinsic apoptosis by permeabilising the mitochondrial outer membrane. Their activity is regulated through interactions with pro-survival BCL-2 family proteins and with non-BCL-2 proteins including the mitochondrial po…
View article: Changes in ferrous iron and glutathione promote ferroptosis and frailty in aging Caenorhabditis elegans
Changes in ferrous iron and glutathione promote ferroptosis and frailty in aging Caenorhabditis elegans Open
All eukaryotes require iron. Replication, detoxification, and a cancer-protective form of regulated cell death termed ferroptosis, all depend on iron metabolism. Ferrous iron accumulates over adult lifetime in Caenorhabditis elegans. Here,…
View article: Activation and clustering of a <i>Plasmodium falciparum var</i> gene are affected by subtelomeric sequences
Activation and clustering of a <i>Plasmodium falciparum var</i> gene are affected by subtelomeric sequences Open
The Plasmodium falciparum var multigene family encodes the cytoadhesive, variant antigen Pf EMP 1. P. falciparum antigenic variation and cytoadhesion specificity are controlled by epigenetic switching between the single, or few, simultaneo…
View article: Differences in PfEMP1s recognized by antibodies from patients with uncomplicated or severe malaria
Differences in PfEMP1s recognized by antibodies from patients with uncomplicated or severe malaria Open
These data suggest that exposure to a broad range of group A and B PfEMP1s is associated with protection from severe disease in Papua, Indonesia.