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View article: Prematurely Aged Human Microglia Exhibit Impaired Stress Response and Defective Nucleocytoplasmic Shuttling of <scp>ALS</scp> Associated <scp>FUS</scp>
Prematurely Aged Human Microglia Exhibit Impaired Stress Response and Defective Nucleocytoplasmic Shuttling of <span>ALS</span> Associated <span>FUS</span> Open
Microglia, the brain's resident immune cells, are crucial for maintaining healthy brain homeostasis. However, as the brain ages, microglia can shift from a neuroprotective to a neurotoxic phenotype, contributing to chronic inflammation and…
Hyperoxia shows duration-dependent effects on the lengths of cell cycle phases in fetal cortical neural stem cells Open
Fetal neural stem cells (NSCs) physiologically reside under low-oxygen conditions (1%–5% of tissue pO 2 ), but are often transferred and maintained under atmospheric oxygen levels of 21% pO 2 (hyperoxia) for in vitro investigations. These …
View article: Mitochondrial <scp>DNA</scp> replication is essential for neurogenesis but not gliogenesis in fetal neural stem cells
Mitochondrial <span>DNA</span> replication is essential for neurogenesis but not gliogenesis in fetal neural stem cells Open
Mitochondria are unique organelles that have their own genome (mtDNA) and perform various pivotal functions within a cell. Recently, evidence has highlighted the role of mitochondria in the process of stem cell differentiation, including d…
View article: Circadian variations influence anxiety-related behaviour, olfaction, and hedonic response in male Sprague–Dawley rats
Circadian variations influence anxiety-related behaviour, olfaction, and hedonic response in male Sprague–Dawley rats Open
This study demonstrates extensive circadian influences on nearly all parameters investigated, coupled with a significant reduction in data variability during the active phase. Emphasising the importance of aligning experimental timing with…
View article: Subthalamic nucleus deep brain stimulation induces nigrostriatal dopaminergic plasticity in a stable rat model of Parkinson’s disease
Subthalamic nucleus deep brain stimulation induces nigrostriatal dopaminergic plasticity in a stable rat model of Parkinson’s disease Open
Objective Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has been a highly effective treatment option for middle to late stage Parkinson’s disease for decades. Though, the underlying mechanisms of action, particularly effect…
Notch is Not Involved in Physioxia-Mediated Stem Cell Maintenance in Midbrain Neural Stem Cells Open
Notch signalling does not influence the fate decision of midbrain NSCs cultured in vitro in physioxia, where other factors like Hif-1α might be involved. Our findings on how physioxia effects in midbrain NSCs are transduced by alternative …
View article: Serial Gene Expression Profiling of Neural Stem Cells Shows Transcriptome Switch by Long-Term Physioxia from Metabolic Adaption to Cell Signaling Profile
Serial Gene Expression Profiling of Neural Stem Cells Shows Transcriptome Switch by Long-Term Physioxia from Metabolic Adaption to Cell Signaling Profile Open
Oxygen is an essential factor in the cellular microenvironment with pivotal effects on neural development with a particular sensitivity of midbrain neural stem cells (NSCs) to high atmospheric oxygen tension. However, most experiments are …
View article: Hyperoxygenation During Mid-Neurogenesis Accelerates Cortical Development in the Fetal Mouse Brain
Hyperoxygenation During Mid-Neurogenesis Accelerates Cortical Development in the Fetal Mouse Brain Open
Oxygen tension is well-known to affect cortical development. Fetal brain hyperoxygenation during mid-neurogenesis in mice (embryonic stage E14.5. to E16.5) increases brain size evoked through an increase of neuroprecursor cells. Neverthele…
View article: Catecholaminergic Innervation of Periventricular Neurogenic Regions of the Developing Mouse Brain
Catecholaminergic Innervation of Periventricular Neurogenic Regions of the Developing Mouse Brain Open
The major catecholamines-dopamine (DA) and norepinephrine (NE)-are not only involved in synaptic communication but also act as important trophic factors and might ultimately be involved in mammalian brain development. The catecholaminergic…
View article: Early Chronic Intermittent Maternal Hyperoxygenation Impairs Cortical Development by Inhibition of Pax6-Positive Apical Progenitor Cell Proliferation
Early Chronic Intermittent Maternal Hyperoxygenation Impairs Cortical Development by Inhibition of Pax6-Positive Apical Progenitor Cell Proliferation Open
Maternal hyperoxygenation is a feasible, noninvasive method to treat fetal diseases, such as heart hypoplasia, but effects of maternal hyperoxygenation on the developing brain remain poorly understood. Previous studies showed that short-te…