Franziska V. Kraus
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View article: Negative impact of Interleukin-9 on synovial regulatory T cells in rheumatoid arthritis
Negative impact of Interleukin-9 on synovial regulatory T cells in rheumatoid arthritis Open
View article: Staphylococci planktonic and biofilm environments differentially affect osteoclast formation
Staphylococci planktonic and biofilm environments differentially affect osteoclast formation Open
Introduction The pathophysiology of chronic implant-related bone infections is characterized by an increase in osteoclast numbers and enhanced bone resorption. Biofilms are a major reason for chronicity of such infections as the biofilm ma…
View article: Bacterial and Metabolic Factors of Staphylococcal Planktonic and Biofilm Environments Differentially Regulate Macrophage Immune Activation
Bacterial and Metabolic Factors of Staphylococcal Planktonic and Biofilm Environments Differentially Regulate Macrophage Immune Activation Open
Biofilm formation is a leading cause for chronic implant-related bone infections as biofilms shield bacteria against the immune system and antibiotics. Additionally, biofilms generate a metabolic microenvironment that shifts the immune res…
View article: Reduction of pro-inflammatory effector functions through remodeling of fatty acid metabolism in CD8<sup>+</sup> T-cells from Rheumatoid Arthritis patients
Reduction of pro-inflammatory effector functions through remodeling of fatty acid metabolism in CD8<sup>+</sup> T-cells from Rheumatoid Arthritis patients Open
Objectives RA CD8 + T-cells (CD8) maintain their effector pro-inflammatory phenotype by changing their metabolism towards aerobic glycolysis. However, their massive energetic and biosynthetic needs may require additional substrates to furn…
View article: Acod1 negatively impacts osteoclastogenesis via GPR91-mediated NFATc1 activation
Acod1 negatively impacts osteoclastogenesis via GPR91-mediated NFATc1 activation Open
Immune cells undergo metabolic reprogramming upon exposure to inflammatory stimuli. The immuneresponsive gene 1 ( Irg1 ) encodes aconitate decarboxylase (Acod1), an enzyme that generates itaconate from cis-aconitate in the TCA cycle and is…
View article: Distinct immune-effector and metabolic profile of CD8<sup>+</sup> T Cells in patients with autoimmune polyarthritis induced by therapy with immune-checkpoint inhibitors
Distinct immune-effector and metabolic profile of CD8<sup>+</sup> T Cells in patients with autoimmune polyarthritis induced by therapy with immune-checkpoint inhibitors Open
Objectives Rheumatic immune-related adverse events (irAE) such as (poly)arthritis in patients undergoing immune checkpoint inhibitor (ICI) treatment pose a major clinical challenge. ICI-therapy improves CD8+ T cell (CD8) function, but CD8 …
View article: Bacterial and metabolic factors of staphylococcal planktonic and biofilm environments differentially regulate macrophage immune activation
Bacterial and metabolic factors of staphylococcal planktonic and biofilm environments differentially regulate macrophage immune activation Open
Biofilm formation is a leading cause for chronic implant-related bone infections as biofilms shield bacteria against the immune system and antibiotics. Additionally, biofilms generate a metabolic microenvironment that shifts the immune res…