Andrea Frapporti
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View article: The tiny germline chromosomes of Paramecium aurelia have an exceptionally high recombination rate and are capped by a new class of Helitrons
The tiny germline chromosomes of Paramecium aurelia have an exceptionally high recombination rate and are capped by a new class of Helitrons Open
Background. Paramecia belong to the ciliate phylum of unicellular eukaryotes characterized by nuclear dimorphism. A diploid germline micronucleus (MIC) transmits genetic information across sexual generations. A polyploid transcriptionally …
View article: A histone methyltransferase-independent function of PRC2 controls small RNA dynamics during programmed DNA elimination in <i>Paramecium</i>
A histone methyltransferase-independent function of PRC2 controls small RNA dynamics during programmed DNA elimination in <i>Paramecium</i> Open
To limit transposable element (TE) mobilization, most eukaryotes have evolved small RNAs to silence TE activity via homology-dependent mechanisms. Small RNAs, 20–30 nucleotides in length, bind to PIWI proteins and guide them to nascent tra…
View article: A histone methyltransferase-independent function of PRC2 controls small RNA dynamics during programmed DNA elimination in Paramecium
A histone methyltransferase-independent function of PRC2 controls small RNA dynamics during programmed DNA elimination in Paramecium Open
To limit transposable element (TE) mobilization, most eukaryotes have evolved small RNAs to silence TE activity via homology-dependent mechanisms. Small RNAs, 20-30 nucleotides in length, bind to PIWI proteins and guide them to nascent tra…
View article: Non-catalytic function of PRC2 in the control of small RNA dynamics during programmed genome elimination in Paramecium
Non-catalytic function of PRC2 in the control of small RNA dynamics during programmed genome elimination in Paramecium Open
To limit transposable element (TE) mobilization, most eukaryotes have evolved small RNAs to silence TE activity via homology-dependent mechanisms. Small RNAs, 20-30 nucleotides in length, bind to PIWI proteins and guide them to nascent tra…
View article: Non-catalytic function of PRC2 in the control of small RNA dynamics during programmed genome elimination in Paramecium
Non-catalytic function of PRC2 in the control of small RNA dynamics during programmed genome elimination in Paramecium Open
To limit transposable element (TE) mobilization, most eukaryotes have evolved small RNAs to silence TE activity via homology-dependent mechanisms. Small RNAs, 20-30 nucleotides in length, guide PIWI proteins to which they bind, to nascent …
View article: A histone methyltransferase-independent function of PRC2 controls small RNA dynamics during programmed DNA elimination in <i>Paramecium</i>
A histone methyltransferase-independent function of PRC2 controls small RNA dynamics during programmed DNA elimination in <i>Paramecium</i> Open
To limit transposable element (TE) mobilization, most eukaryotes have evolved small RNAs to silence TE activity via homology-dependent mechanisms. Small RNAs, 20-30 nucleotides in length, bind to PIWI proteins and guide them to nascent tra…
View article: DREAM represses distinct targets by cooperating with different THAP domain proteins
DREAM represses distinct targets by cooperating with different THAP domain proteins Open
View article: The Paramecium histone chaperone Spt16-1 is required for Pgm endonuclease function in programmed genome rearrangements
The Paramecium histone chaperone Spt16-1 is required for Pgm endonuclease function in programmed genome rearrangements Open
In Paramecium tetraurelia, a large proportion of the germline genome is reproducibly removed from the somatic genome after sexual events via a process involving small (s)RNA-directed heterochromatin formation and DNA excision and repair. H…
View article: The Polycomb protein Ezl1 mediates H3K9 and H3K27 methylation to repress transposable elements in Paramecium
The Polycomb protein Ezl1 mediates H3K9 and H3K27 methylation to repress transposable elements in Paramecium Open
View article: DNA deletion as a mechanism for developmentally programmed centromere loss
DNA deletion as a mechanism for developmentally programmed centromere loss Open
A hallmark of active centromeres is the presence of the histone H3 variant CenH3 in the centromeric chromatin, which ensures faithful genome distribution at each cell division. A functional centromere can be inactivated, but the molecular …