Frauke Brinkmann
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Membrane Tension Regulation is Required for Wound Repair (Adv. Sci. 48/2024) Open
Tension‐Mediated Wound Repair Endothelial cells (yellow) that line all blood vessels of the human body can experience plasma membrane wounds, as shown by laser injury (left half). The wound is rapidly resealed by exocytosis of early endoso…
Membrane Tension Regulation is Required for Wound Repair Open
Disruptions of the eukaryotic plasma membrane due to chemical and mechanical challenges are frequent and detrimental and thus need to be repaired to maintain proper cell function and avoid cell death. However, the cellular mechanisms invol…
Membrane tension regulation is required for wound repair Open
Disruptions of the eukaryotic plasma membrane due to chemical and mechanical challenges are frequent and detrimental, and thus need to be repaired to maintain proper cell function and avoid cell death. However, the cellular mechanisms invo…
RhoGDI1 regulates cell-cell junctions in polarized epithelial cells Open
Cell-cell contact formation of polarized epithelial cells is a multi-step process that involves the co-ordinated activities of Rho family small GTPases. Consistent with the central role of Rho GTPases, a number of Rho guanine nucleotide ex…
A JAM-A–tetraspanin–αvβ5 integrin complex regulates contact inhibition of locomotion Open
Contact inhibition of locomotion (CIL) is a process that regulates cell motility upon collision with other cells. Improper regulation of CIL has been implicated in cancer cell dissemination. Here, we identify the cell adhesion molecule JAM…
A novel adhesive complex at the base of intestinal microvilli Open
Intestinal epithelial cells form dense arrays of microvilli at the apical membrane to enhance their functional capacity. Microvilli contain a protocadherin-based intermicrovillar adhesion complex localized at their tips which regulates mic…