Explanipedia

Memory B cell Development in Response to mRNA SARS-CoV-2 and Nanoparticle Immunization in Mice Open

Marie Wiatr, zijun wang, Marie Canis, Anna Gazumyan, B. Hernández , et al. · 2025

Nanoparticle immunogens excel at rapidly inducing high levels of circulating antibodies and are being deployed as part of several novel vaccines. However, their ability to elicit memory B cell responses is less well understood. Here we com…

Correction: Transcription of HIV-1 at sites of intact latent provirus integration Open

Ana Rafaela Teixeira, Cíntia Bittar, Gabriela S. Silva Santos, Thiago Y. Oliveira, Amy S. Huang , et al. · 2025

Probing Gag-Env dynamics at HIV-1 assembly sites using live-cell microscopy Open

Frauke Muecksch, Severina Klaus, Vibor Laketa, Bárbara Müller, Hans‐Georg Kräusslich · 2024

Human immunodeficiency virus (HIV)-1 assembly is initiated by Gag binding to the inner leaflet of the plasma membrane (PM). Gag targeting is mediated by its N-terminally myristoylated matrix (MA) domain and PM phosphatidylinositol 4,5-bisp…

Transcription of HIV-1 at sites of intact latent provirus integration Open

Ana Rafaela Teixeira, Cíntia Bittar, Gabriela S. Silva Santos, Thiago Y. Oliveira, Amy S. Huang , et al. · 2024

HIV-1 antiretroviral therapy is highly effective but fails to eliminate a reservoir of latent proviruses, leading to a requirement for life-long treatment. How the site of integration of authentic intact latent proviruses might impact thei…

Transcription of HIV-1 at sites of intact latent provirus integration Open

Ana Rafaela Teixeira, Cíntia Bittar, Gabriela S. Silva Santos, Thiago Y. Oliveira, Amy S. Huang , et al. · 2024

HIV-1 anti-retroviral therapy is highly effective but fails to eliminate a reservoir of latent proviruses leading to a requirement for life-long treatment. How the site of integration of authentic intact latent proviruses might impact thei…

Eliciting CD4-mimicking broadly neutralizing antibodies: new avenues towards the rational design of an HIV vaccine Open

Frauke Muecksch, O. Fackler · 2024

SARS-CoV-2 spike glycosylation affects function and neutralization sensitivity Open

Fengwen Zhang, Fabian Schmidt, Frauke Muecksch, Zijun Wang, Anna Gazumyan , et al. · 2024

The attachment of glycans to the spike proteins of viruses during their synthesis and movement through the secretory pathway can affect their properties. This study shows that the glycans attached to the severe acute respiratory syndrome c…

SARS-CoV-2 spike glycosylation affects function and neutralization sensitivity Open

Fengwen Zhang, Fabian Schmidt, Frauke Muecksch, Zijun Wang, Anna Gazumyan , et al. · 2023

The glycosylation of viral envelope proteins can play important roles in virus biology and immune evasion. The spike (S) glycoprotein of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) includes 22 N-linked glycosylation sequon…

Memory B cell development elicited by mRNA booster vaccinations in the elderly Open

Zijun Wang, Frauke Muecksch, Raphael Raspe, Frederik Johannsen, Martina Turroja , et al. · 2023

Despite mRNA vaccination, elderly individuals remain especially vulnerable to severe consequences of SARS-CoV-2 infection. Here, we compare the memory B cell responses in a cohort of elderly and younger individuals who received mRNA booste…

Antigen presentation dynamics shape the antibody response to variants like SARS-CoV-2 Omicron after multiple vaccinations with the original strain Open

Leerang Yang, Matthew Van Beek, Zijun Wang, Frauke Muecksch, Marie Canis , et al. · 2023

Epistasis lowers the genetic barrier to SARS-CoV-2 neutralizing antibody escape Open

Leander Witte, Viren A. Baharani, Fabian Schmidt, Zijun Wang, Alice Cho , et al. · 2023

Waves of SARS-CoV-2 infection have resulted from the emergence of viral variants with neutralizing antibody resistance mutations. Simultaneously, repeated antigen exposure has generated affinity matured B cells, producing broadly neutraliz…

Antibody feedback regulates immune memory after SARS-CoV-2 mRNA vaccination Open

Dennis Schaefer-Babajew, Zijun Wang, Frauke Muecksch, Alice Cho, Maximilian Loewe , et al. · 2022

Memory B cell responses to Omicron subvariants after SARS-CoV-2 mRNA breakthrough infection in humans Open

Zijun Wang, Pengcheng Zhou, Frauke Muecksch, Alice Cho, Tarek Ben Tanfous , et al. · 2022

Individuals who receive a third mRNA vaccine dose show enhanced protection against severe COVID-19, but little is known about the impact of breakthrough infections on memory responses. Here, we examine the memory antibodies that develop af…

Antigen presentation dynamics shape the response to emergent variants like SARS-CoV-2 Omicron strain after multiple vaccinations with wild type strain Open

Leerang Yang, Matthew Van Beek, Zijun Wang, Frauke Muecksch, Marie Canis , et al. · 2022

Summary The Omicron variant of SARS-CoV-2 evades neutralization by most serum antibodies elicited by two doses of mRNA vaccines, but a third dose of the same vaccine increases anti-Omicron neutralizing antibodies. By combining computationa…

Epistasis lowers the genetic barrier to SARS-CoV-2 neutralizing antibody escape Open

Leander Witte, Viren A. Baharani, Fabian Schmidt, Zijun Wang, Alice Cho , et al. · 2022

Consecutive waves of SARS-CoV-2 infection have been driven in part by the repeated emergence of variants with mutations that confer resistance to neutralizing antibodies Nevertheless, prolonged or repeated antigen exposure generates divers…

Memory B cell responses to Omicron subvariants after SARS-CoV-2 mRNA breakthrough infection Open

Zijun Wang, Pengcheng Zhou, Frauke Muecksch, Alice Cho, Tarek Ben Tanfous , et al. · 2022

Individuals that receive a 3 rd mRNA vaccine dose show enhanced protection against severe COVID19 but little is known about the impact of breakthrough infections on memory responses. Here, we examine the memory antibodies that develop afte…

Antibody feedback regulation of memory B cell development in SARS-CoV-2 mRNA vaccination Open

Dennis Schaefer-Babajew, Zijun Wang, Frauke Muecksch, Alice Cho, Raphael Raspe , et al. · 2022

Feedback inhibition of humoral immunity by antibodies was initially documented in guinea pigs by Theobald Smith in 1909, who showed that passive administration of excess anti-Diphtheria toxin inhibited immune responses 1 . Subsequent work …

Structural basis for host tRNA control of HIV-1 Gag localization Open

Charles Bou‐Nader, Frauke Muecksch, Janae Brown, Michael F. Summers, Paul D. Bieniasz , et al. · 2022

The HIV-1 Gag polyprotein drives and coordinates all steps in viral particle assembly.Indeed, the sole expression of Gag in human cells is sufficient to form virus-like particles that are nearly indistinguishable from immature virions (1).…

Humoral immunity to SARS-CoV-2 elicited by combination COVID-19 vaccination regimens Open

Zijun Wang, Frauke Muecksch, Friederike Muenn, Alice Cho, Shuai Zong , et al. · 2022

The SARS-CoV-2 pandemic prompted a global vaccination effort and the development of numerous COVID-19 vaccines at an unprecedented scale and pace. As a result, current COVID-19 vaccination regimens comprise diverse vaccine modalities, immu…

Plasma and memory antibody responses to Gamma SARS-CoV-2 provide limited cross-protection to other variants Open

Marianna Agudelo, Frauke Muecksch, Dennis Schaefer-Babajew, Alice Cho, Justin DaSilva , et al. · 2022

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to be a global problem in part because of the emergence of variants of concern that evade neutralization by antibodies elicited by prior infection or vaccination. Here …

Antibody evolution to SARS-CoV-2 after single-dose Ad26.COV2.S vaccine in humans Open

Alice Cho, Frauke Muecksch, Zijun Wang, Tarek Ben Tanfous, Justin DaSilva , et al. · 2022

The single-dose Ad.26.COV.2 (Janssen) vaccine elicits lower levels of neutralizing antibodies and shows more limited efficacy in protection against infection than either of the two available mRNA vaccines. In addition, Ad.26.COV.2 has been…

Longitudinal variation in SARS-CoV-2 antibody levels and emergence of viral variants: a serological analysis Open

Frauke Muecksch, Helen Wise, Kate Templeton, Becky Batchelor, Maria Squires , et al. · 2022

US National Institutes of Health and National Health Service Research Scotland BioResource.

Humoral immunity to SARS-CoV-2 elicited by combination COVID-19 vaccination regimens Open

Zijun Wang, Frauke Muecksch, Friederike Muenn, Alice Cho, Shuai Zong , et al. · 2022

The SARS-CoV-2 pandemic prompted a global vaccination effort and the development of numerous COVID-19 vaccines at an unprecedented scale and pace. As a result, current COVID- 19 vaccination regimens comprise diverse vaccine modalities, imm…

Severe Acute Respiratory Syndrome Coronavirus 2 Neutralization After Messenger RNA Vaccination and Variant Breakthrough Infection Open

Christian Gaebler, Justin DaSilva, Eva Bednarski, Frauke Muecksch, Fabian Schmidt , et al. · 2022

The emergence of severe acute respiratory syndrome coronavirus 2 variants that have greater transmissibility and resistance to neutralizing antibodies has increased the incidence of breakthrough infections. We show that breakthrough infect…

Increased memory B cell potency and breadth after a SARS-CoV-2 mRNA boost Open

Frauke Muecksch, Zijun Wang, Alice Cho, Christian Gaebler, Tarek Ben Tanfous , et al. · 2022

The Omicron variant of SARS-CoV-2 infected many vaccinated and convalescent individuals 1–3 . Despite the reduced protection from infection, individuals who received three doses of an mRNA vaccine were highly protected from more serious co…

Analysis of memory B cells identifies conserved neutralizing epitopes on the N-terminal domain of variant SARS-Cov-2 spike proteins Open

Zijun Wang, Frauke Muecksch, Alice Cho, Christian Gaebler, Hans-Heinrich Hoffmann , et al. · 2022

Antibody evolution to SARS-CoV-2 after single-dose Ad26.COV2.S vaccine Open

Alice Cho, Frauke Muecksch, Zijun Wang, Tarek Ben Tanfous, Justin DaSilva , et al. · 2022

The single dose Ad.26.COV.2 (Janssen) vaccine elicits lower levels of neutralizing antibodies and shows more limited efficacy in protection against infection than either of the available mRNA vaccines. In addition, the Ad.26.COV.2 has been…

Evaluation of SARS-CoV-2 antibody point of care devices in the laboratory and clinical setting Open

Kirsty McCance, Helen Wise, Jennifer Simpson, Becky Batchelor, Harriet M. Van Hale , et al. · 2022

SARS-CoV-2 antibody tests have been marketed to diagnose previous SARS-CoV-2 infection and as a test of immune status. There is a lack of evidence on the performance and clinical utility of these tests. We aimed to carry out an evaluation …

Author response: Coagulation factors directly cleave SARS-CoV-2 spike and enhance viral entry Open

Edward R. Kastenhuber, Marisa Mercadante, Benjamin E. Nilsson-Payant, Jared L. Johnson, Javier A. Jaimes , et al. · 2022

Increased Potency and Breadth of SARS-CoV-2 Neutralizing Antibodies After a Third mRNA Vaccine Dose Open

Frauke Muecksch, Zijun Wang, Alice Cho, Christian Gaebler, Tarek Ben Tanfous , et al. · 2022

The omicron variant of SARS-CoV-2 infected very large numbers of SARS-CoV-2 vaccinated and convalescent individuals 1–3 . The penetrance of this variant in the antigen experienced human population can be explained in part by the relatively…

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