Fred Etoc
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View article: Deep-learning analysis of micropattern-based organoids enables high-throughput drug screening of Huntington’s disease models
Deep-learning analysis of micropattern-based organoids enables high-throughput drug screening of Huntington’s disease models Open
Organoids are carrying the promise of modeling complex disease phenotypes and serving as a powerful basis for unbiased drug screens, potentially offering a more efficient drug-discovery route. However, unsolved technical bottlenecks of rep…
View article: Role of YAP in early ectodermal specification and a Huntington's Disease model of human neurulation
Role of YAP in early ectodermal specification and a Huntington's Disease model of human neurulation Open
The Hippo pathway, a highly conserved signaling cascade that functions as an integrator of molecular signals and biophysical states, ultimately impinges upon the transcription coactivator Yes-associated protein 1 (YAP). Hippo-YAP signaling…
View article: Author response: Role of YAP in early ectodermal specification and a Huntington's Disease model of human neurulation
Author response: Role of YAP in early ectodermal specification and a Huntington's Disease model of human neurulation Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The Hippo pathway, a h…
View article: Self-organization of human dorsal-ventral forebrain structures by light induced SHH
Self-organization of human dorsal-ventral forebrain structures by light induced SHH Open
Organizing centers secrete morphogens that specify the emergence of germ layers and the establishment of the body’s axes during embryogenesis. While traditional experimental embryology tools have been instrumental in dissecting the molecul…
View article: Huntingtin CAG expansion impairs germ layer patterning in synthetic human 2D gastruloids through polarity defects
Huntingtin CAG expansion impairs germ layer patterning in synthetic human 2D gastruloids through polarity defects Open
Huntington's disease (HD) is a fatal neurodegenerative disorder caused by an expansion of the CAG repeats in the huntingtin gene (HTT). Although HD has been shown to have a developmental component, how early during human embryogenesis the …
View article: Self-organization of human dorsal-ventral forebrain structures by light induced SHH
Self-organization of human dorsal-ventral forebrain structures by light induced SHH Open
Summary Organizing centers secrete morphogens that specify the emergence of germ layers and the establishment of the body’s axes during embryogenesis. While traditional experimental embryology tools have been instrumental in dissecting the…
View article: Role of YAP in early ectodermal specification and a Huntington’s Disease model of human neurulation
Role of YAP in early ectodermal specification and a Huntington’s Disease model of human neurulation Open
The Hippo pathway, a highly conserved signaling cascade that functions as an integrator of molecular signals and biophysical states, ultimately impinges upon the transcription coactivator Yes-associated protein 1 (YAP). Hippo-YAP signaling…
View article: A method to recapitulate early embryonic spatial patterning in human embryonic stem cells v1
A method to recapitulate early embryonic spatial patterning in human embryonic stem cells v1 Open
Embryos allocate cells to the three germ layers in a spatially ordered sequence. Human embryonic stem cells (hESCs) can generate the three germ layers in culture, however, differentiation is typically heterogeneous and spatially disordered…
View article: Huntingtin CAG expansion impairs germ layer patterning in synthetic human gastruloids through polarity defects
Huntingtin CAG expansion impairs germ layer patterning in synthetic human gastruloids through polarity defects Open
Huntington’s disease (HD) is a fatal neurodegenerative disorder caused by an expansion of the CAG repeats in the Huntingtin gene ( HTT ). While HD has been shown to have a developmental component, how early during human embryogenesis the H…
View article: Differential compartmentalization of BMP4/NOGGIN requires NOGGIN trans-epithelial transport
Differential compartmentalization of BMP4/NOGGIN requires NOGGIN trans-epithelial transport Open
Using self-organizing human models of gastrulation, we previously showed that (i) BMP4 initiates the cascade of events leading to gastrulation; (ii) BMP4 signal-reception is restricted to the basolateral domain; and (iii) in a human-specif…
View article: Diffusion of nanoparticles in the cell cytoplasm
Diffusion of nanoparticles in the cell cytoplasm Open
In Etoc 2018, we presented the diffusive behavior inside the cytosol of living cells for different kind of nanometric sized nanoparticles. We showed that the passivation of the particles is the main parameter that regulate the diffusion pr…
View article: Diffusion of nanoparticles in the cell cytoplasm
Diffusion of nanoparticles in the cell cytoplasm Open
In Etoc 2018, we presented the diffusive behavior inside the cytosol of living cells for different kind of nanometric sized nanoparticles. We showed that the passivation of the particles is the main parameter that regulate the diffusion pr…
View article: WNT signaling memory is required for ACTIVIN to function as a morphogen in human gastruloids
WNT signaling memory is required for ACTIVIN to function as a morphogen in human gastruloids Open
Self-organization of discrete fates in human gastruloids is mediated by a hierarchy of signaling pathways. How these pathways are integrated in time, and whether cells maintain a memory of their signaling history remains obscure. Here, we …
View article: Author response: WNT signaling memory is required for ACTIVIN to function as a morphogen in human gastruloids
Author response: WNT signaling memory is required for ACTIVIN to function as a morphogen in human gastruloids Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Self-organization of discrete…
View article: WNT signaling memory is required for ACTIVIN to function as a morphogen in human gastruloids
WNT signaling memory is required for ACTIVIN to function as a morphogen in human gastruloids Open
Self-organization of discrete fates in human gastruloids is mediated by a hierarchy of signaling pathways. How these pathways are integrated in time, and whether cells maintain a memory of their signaling history remains obscure. Here, we …
View article: Molecular mechanism of symmetry breaking in a 3D model of a human epiblast
Molecular mechanism of symmetry breaking in a 3D model of a human epiblast Open
Breaking the anterior-posterior (AP) symmetry in mammals takes place at gastrulation. Much of the signaling network underlying this process has been elucidated in the mouse, however there is no direct molecular evidence of events driving a…