Explanipedia

Comorbidities in Adolescents With Congenital Heart Disease: A Population-Based Study Open

Matthew R. Reeder, George K. Lui, Marcia L. Feldkamp, Jill Glidewell, Tessa Crume , et al. · 2025

OBJECTIVES We evaluated the frequency and patterns of comorbidity and multimorbidity in adolescents with congenital heart disease (CHD) using data from a multisite population-based surveillance project. METHODS Adolescents aged 11 to 18 ye…

Heart Failure Management in the Adult Congenital Heart Disease Patient: Part II: Nonpharmacological Therapies Open

Juan Ortega–Legaspi, Arwa Saidi, Fred H. Rodriguez, Wilson Lam, Andrew Pistner , et al. · 2025

Comorbidity and Multimorbidity in Adults With Congenital Heart Disease: Findings From a Multi‐Site Population‐Based Study Open

Lorenzo D. Botto, Matthew R. Reeder, George K. Lui, Jill Glidewell, Wendy M. Book , et al. · 2025

Background Survival of individuals with congenital heart disease (CHD) has improved, leading to a growing and aging population of adults living with these conditions. Over their lifetime, they often face an array of comorbidities that affe…

Characteristics and Survival Outcomes of Hepatocellular Carcinoma After the Fontan Operation Open

Benjamin Rosenthal, Maarouf Hoteit, Gentian Lluri, Christiane Haeffele, Tami Daugherty , et al. · 2025

Machine Learning and Natural Language Processing to Improve Classification of Atrial Septal Defects in Electronic Health Records Open

Yuting Guo, Haoming Shi, Wendy Book, Lindsey C. Ivey, Fred H. Rodriguez , et al. · 2025

Background International Classification of Disease (ICD) codes can accurately identify patients with certain congenital heart defects (CHDs). In ICD‐defined CHD data sets, the code for secundum atrial septal defect (ASD) is the most common…

Propensity Score Analysis of Possible Medication Effects on Outcomes in Patients With Systemic Right Ventricles Open

Amrit Misra, Carla P. Rodríguez-Monserrate, Kimberlee Gauvreau, Mikael Dellborg, Flavia Fusco , et al. · 2024

In this large multicenter propensity-matched observational study, patients with SRV taking beta-blockers or ACEI/ARB did not have a benefit in survival or reduced hospitalization. The likelihood of demonstrating favorable effects in larger…

Racial and Ethnic Disparities in Health Care Usage and Death by Neighborhood Poverty Among Individuals With Congenital Heart Defects, 4 US Surveillance Sites, 2011 to 2013 Open

Cheryl Raskind‐Hood, Vijaya Kancherla, Lindsey C. Ivey, Fred H. Rodriguez, Anaclare M. Sullivan , et al. · 2024

Background Socioeconomic factors may lead to a disproportionate impact on health care usage and death among individuals with congenital heart defects (CHD) by race, ethnicity, and socioeconomic factors. How neighborhood poverty affects rac…

Racial and Ethnic Disparities in Healthcare Utilization and Mortality by Neighborhood Poverty among Individuals with Congenital Heart Defects, four U.S. Surveillance Sites, 2011-2013 Open

Cheryl Raskind‐Hood, Vijaya Kancherla, Lindsey C. Ivey, Fred H. Rodriguez, Anaclare M. Sullivan , et al. · 2023

BACKGROUND Socioeconomic factors may lead to a disproportionate impact on healthcare utilization and mortality among individuals with congenital heart defects (CHD) by race, ethnicity, and socio-economic factors. How neighborhood poverty a…

Hepatocellular carcinoma in survivors after Fontan operation: a case–control study Open

Yuli Y. Kim, Gentian Lluri, Christiane Haeffele, Tami Daugherty, Richard A. Krasuski , et al. · 2023

Journal Article Hepatocellular carcinoma in survivors after Fontan operation: a case–control study Get access Yuli Y Kim, Yuli Y Kim Division of Cardiology, Hospital of the University of Pennsylvania, Perelman Center for Advanced Medicine,…

COVID-19–Related Thrombotic and Bleeding Events in Adults With Congenital Heart Disease Open

Flavia Fusco, Richard A. Krasuski, Soraya Sadeghi, Marlon Rosenbaum, Matthew Lewis , et al. · 2023

ACHD patients with TE/bleeding during COVID-19 infection have a higher in-hospital mortality from the illness. Risk of coagulation disorders is related to severe COVID-19, cardiac injury during infection, and use of anticoagulants.

A machine learning model for predicting congenital heart defects from administrative data Open

Haoming Shi, Wendy Book, Cheryl Raskind‐Hood, Karrie F. Downing, Sherry L. Farr , et al. · 2023

Introduction International Classification of Diseases (ICD) codes recorded in administrative data are often used to identify congenital heart defects (CHD). However, these codes may inaccurately identify true positive (TP) CHD individuals.…

Design and Harmonization Approach for the Multi-Institutional Neurocognitive Discovery Study (MINDS) of Adult Congenital Heart Disease (ACHD) Neuroimaging Ancillary Study: A Technical Note Open

Ashok Panigrahy, Vanessa Schmithorst, Rafael Ceschin, Vince Lee, Nancy Beluk , et al. · 2023

Dramatic advances in the management of congenital heart disease (CHD) have improved survival to adulthood from less than 10% in the 1960s to over 90% in the current era, such that adult CHD (ACHD) patients now outnumber their pediatric cou…

End-stage heart failure in congenitally corrected transposition of the great arteries: a multicentre study Open

Alexandra C. van Dissel, Alexander R. Opotowsky, Luke J. Burchill, Jamil Aboulhosn, Jasmine Grewal , et al. · 2023

Background and Aims For patients with congenitally corrected transposition of the great arteries (ccTGA), factors associated with progression to end-stage congestive heart failure (CHF) remain largely unclear. Methods This multicentre, ret…

Positive Predictive Value of International Classification of Diseases, Ninth Revision, Clinical Modification , and International Classification of Diseases, Tenth Revision, Clinical Modification , Codes for Identification of Congenital Heart Defects Open

Lindsey C. Ivey, Fred H. Rodriguez, Haoming Shi, Cohen Chong, Joy Chen , et al. · 2023

Background Administrative data permit analysis of large cohorts but rely on International Classification of Diseases, Ninth Revision, Clinical Modification ( ICD‐9‐CM ), and International Classification of Diseases, Tenth Revision, Clinica…

Supervised Text Classification System Detects Fontan Patients in Electronic Records With Higher Accuracy Than ICD Codes Open

Yuting Guo, Mohammed Ali Al-Garadi, Wendy Book, Lindsey C. Ivey, Fred H. Rodriguez , et al. · 2023

Background The Fontan operation is associated with significant morbidity and premature mortality. Fontan cases cannot always be identified by International Classification of Diseases ( ICD ) codes, making it challenging to create large Fon…

International Classification of Diseases (ICD) Codes for Congenital Heart Defects (CHD) Have Variable and Limited Accuracy for Detecting CHD Cases Open

Lindsey C. Ivey, Fred H. Rodriguez, Haoming Shi, Cohen Chong, Joy Chen , et al. · 2023

Background Administrative data permits analysis of large cohorts but relies on International Classification of Diseases, Ninth and Tenth Revision, Clinical Modification (ICD) codes that may not reflect true congenital heart defects (CHD). …

How Well Do ICD‐9‐CM Codes Predict True Congenital Heart Defects? A Centers for Disease Control and Prevention‐Based Multisite Validation Project Open

Fred H. Rodriguez, Cheryl Raskind‐Hood, Trenton Hoffman, Sherry L. Farr, Jill Glidewell , et al. · 2022

Background The Centers for Disease Control and Prevention's Surveillance of Congenital Heart Defects Across the Lifespan project uses large clinical and administrative databases at sites throughout the United States to understand populatio…

COVID-19 in Adults With Congenital Heart Disease. Open

Craig S. Broberg, Adrienne H. Kovacs, Soraya Sadeghi, Marlon Rosenbaum, Matthew Lewis , et al. · 2022

This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization…

A Multisite Retrospective Review of Direct Oral Anticoagulants Compared to Warfarin in Adult Fontan Patients Open

Amir Kazerouninia, Justin Georgekutty, Payton Kendsersky, Ryan Byrne, Brendan Seto , et al. · 2022

Giant Coronary Aneurysms in Multisystem Inflammatory Syndrome in Children Associated With SARS-CoV-2 Infection Open

D. Sofia Villacis-Nunez, Sassan Hashemi, Meghan Corrigan Nelson, Elaine Flanagan, Amit Thakral , et al. · 2021

Multisystem inflammatory syndrome in children (MIS-C) can cause a myriad of cardiac manifestations, including coronary dilation and aneurysms; giant aneurysms are infrequent. We describe 3patients with giant coronary aneurysms associated w…

COVID-19 in Adults With Congenital Heart Disease Open

Craig S. Broberg, Adrienne H. Kovacs, Soraya Sadeghi, Marlon Rosenbaum, Matthew Lewis , et al. · 2021

Recurrent sustained atrial arrhythmias and thromboembolism in Fontan patients with total cavopulmonary connection Open

Alexander C. Egbe, William R. Miranda, Janaki Devara, Likhita Shaik, Momina Iftikhar , et al. · 2021

Although TCPC provides superior flow dynamics and lower risk of incident atrial arrhythmias, there is a significant risk of recurrent arrhythmias among TCPC patients with a prior history of atrial arrhythmias. These patients may require mo…

Single-Barrel, Double-Barrel, and Fenestrated Endografts to Facilitate Transcatheter Pulmonary Valve Replacement in Large RVOT Open

Norihiko Kamioka, Vasilis Babaliaros, John Lisko, Anurag Sahu, Subhadra Shashidharan , et al. · 2020

Absent B cells, agammaglobulinemia, and hypertrophic cardiomyopathy in folliculin-interacting protein 1 deficiency Open

Francesco Saettini, M. Cecilia Poli, Jaime Vengoechea, Sonia Bonanomi, Julio César Orellana , et al. · 2020

Agammaglobulinemia is the most profound primary antibody deficiency that can occur due to an early termination of B-cell development. We here investigated 3 novel patients, including the first known adult, from unrelated families with agam…

Health Care Transition Perceptions Among Parents of Adolescents with Congenital Heart Defects in Georgia and New York Open

Laura M. Gaydos, Kristin Sommerhalter, Cheryl Raskind‐Hood, Olushola Fapo, George K. Lui , et al. · 2020

Biomarker profile in stable Fontan patients Open

Anita Saraf, Christine De Staercke, Ian Everitt, Alice Haouzi, Yi‐An Ko , et al. · 2020

Assessing Pregnancy, Gestational Complications, and Co-morbidities in Women With Congenital Heart Defects (Data from ICD-9-CM Codes in 3 US Surveillance Sites) Open

Cheryl Raskind‐Hood, Anita Saraf, Tiffany Riehle‐Colarusso, Jill Glidewell, Michelle Gurvitz , et al. · 2019

Lost in the system? Transfer to adult congenital heart disease care—Challenges and solutions Open

Jennifer F. Gerardin, Cheryl Raskind‐Hood, Fred H. Rodriguez, Trenton Hoffman, Andreas P. Kalogeropoulos , et al. · 2019

Patients with severe disease are more likely to transfer to adult congenital heart disease care than nonsevere disease. Most congenital heart disease patients do not transfer to adult congenital cardiology care with distance to referral ce…

Surveillance of Congenital Heart Defects among Adolescents at Three U.S. Sites Open

George K. Lui, Claire McGarry, Ami B. Bhatt, Wendy Book, Tiffany Riehle‐Colarusso , et al. · 2019

The prevalence, co-morbidities, and healthcare utilization in adolescents with congenital heart defects (CHDs) is not well understood. Adolescents (11 to 19 years old) with a healthcare encounter between January 1, 2008 (January 1, 2009 fo…

Cardiac Arrest Refractory to Standard Intervention in Atypical Timothy Syndrome (Lqt8 Type 2) Open

Lucas Philipp, Fred H. Rodriguez · 2016

Timothy syndrome (TS) is a rare, multisystem disorder most commonly associated with profound QTc prolongation and cutaneous dysmorphia arising from mutations of the L-type calcium channel. We present a case of a 12-day-old newborn who pres…

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