Fred Nyberg
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View article: Detecting benzodiazepine use through induced eye convergence inability with a smartphone app: a proof-of-concept study
Detecting benzodiazepine use through induced eye convergence inability with a smartphone app: a proof-of-concept study Open
Background Benzodiazepines (BZDs) are readily available potent drugs that act as central depressants. These drugs are widely used, misused, and abused. For patients with BZD use disorder, the traditional sobriety monitoring method is perio…
View article: Eye reactions under the influence of drugs of abuse as measured by smartphones: a controlled clinical study in healthy volunteers
Eye reactions under the influence of drugs of abuse as measured by smartphones: a controlled clinical study in healthy volunteers Open
Background It is known that illicit and prescribed drugs impact pupil size, eye movement and function. Still, comprehensive quantitative evaluations under known ambient light conditions are lacking, when smartphones are used for monitoring…
View article: Evaluation of 6 years of eHealth data in the alcohol use disorder field indicates improved efficacy of care
Evaluation of 6 years of eHealth data in the alcohol use disorder field indicates improved efficacy of care Open
Background Predictive eHealth tools will change the field of medicine, however long-term data is scarce. Here, we report findings on data collected over 6 years with an AI-based eHealth system for supporting the treatment of alcohol use di…
View article: Revisiting opioid toxicity: Cellular effects of six commonly used opioids
Revisiting opioid toxicity: Cellular effects of six commonly used opioids Open
Objectives There is an ongoing opioid crisis in the United States where the illicit and non-medical use of prescription opioids is associated with an increasing number of overdose deaths. Few studies have investigated opioid-induced effect…
View article: Processing incomplete questionnaire data into continuous digital biomarkers for addiction monitoring
Processing incomplete questionnaire data into continuous digital biomarkers for addiction monitoring Open
Purpose eHealth systems allow efficient daily smartphone-based collection of self-reported data on mood, wellbeing, routines, and motivation; however, missing data is frequent. Within addictive disorders, missing data may reflect lack of m…
View article: Neuropeptide Y and measures of stress in a longitudinal study of women with the fibromyalgia syndrome
Neuropeptide Y and measures of stress in a longitudinal study of women with the fibromyalgia syndrome Open
Objectives Neuropeptide Y is associated with stress in animal and human laboratory studies. However, data from clinical studies are scarce and no clinical longitudinal studies have been published. The aim of this clinical study was to asse…
View article: The Clinical Course of Alcohol Use Disorder Depicted by Digital Biomarkers
The Clinical Course of Alcohol Use Disorder Depicted by Digital Biomarkers Open
Aims: This study introduces new digital biomarkers to be used as precise, objective tools to measure and describe the clinical course of patients with alcohol use disorder (AUD). Methods: An algorithm is outlined for the calculation of a n…
View article: Structurally different anabolic androgenic steroids reduce neurite outgrowth and neuronal viability in primary rat cortical cell cultures
Structurally different anabolic androgenic steroids reduce neurite outgrowth and neuronal viability in primary rat cortical cell cultures Open
The illicit use of anabolic androgenic steroids (AAS) among adolescents and young adults is a major concern due to the unknown and unpredictable impact of AAS on the developing brain and the consequences of this on mental health, cognitive…
View article: Myrcene Attenuates Renal Inflammation and Oxidative Stress in the Adrenalectomized Rat Model
Myrcene Attenuates Renal Inflammation and Oxidative Stress in the Adrenalectomized Rat Model Open
Physiological Glucocorticoids are important regulators of the immune system. Pharmacological GCs are in widespread use to treat inflammatory diseases. Adrenalectomy (ADX) has been shown to exacerbate renal injury through inflammation and o…
View article: Growing knowledge: How growth hormone improves learning
Growing knowledge: How growth hormone improves learning Open
Surging interest on how growth hormone (GH) affects the central nervous system (CNS) is apparent over the latest decades. Various clinics and basic science laboratories suggest important function of GH for many behavioural aspects.1-3 New …
View article: Breathalyser-Based eHealth Data Suggest That Self-Reporting of Abstinence Is a Poor Outcome Measure for Alcohol Use Disorder Clinical Trials
Breathalyser-Based eHealth Data Suggest That Self-Reporting of Abstinence Is a Poor Outcome Measure for Alcohol Use Disorder Clinical Trials Open
Aims To evaluate the efficacy and monitoring capabilities of a breathalyser-based eHealth system for patients with alcohol use disorder (AUD) and to investigate the quality and validity of timeline follow-back (TLFB) as outcome measure in …
View article: Standards for opioid use disorder care: An assessment of Nordic approaches
Standards for opioid use disorder care: An assessment of Nordic approaches Open
Aims: Outcomes in opioid use disorder (OUD) in Nordic countries have improved with integrated treatment and harm-reduction programmes. Approaches and the standard of care are different across the region. Evidence of treatment needs and cur…
View article: The Protective and Restorative Effects of Growth Hormone and Insulin-Like Growth Factor-1 on Methadone-Induced Toxicity In Vitro
The Protective and Restorative Effects of Growth Hormone and Insulin-Like Growth Factor-1 on Methadone-Induced Toxicity In Vitro Open
Evidence to date suggests that opioids such as methadone may be associated with cognitive impairment. Growth hormone (GH) and insulin-like growth factor-1 (IGF-1) are suggested to be neuroprotective and procognitive in the brain and may th…
View article: Real-time Monitoring using a breathalyzer-based eHealth system can identify lapse/relapse patterns in alcohol use disorder Patients
Real-time Monitoring using a breathalyzer-based eHealth system can identify lapse/relapse patterns in alcohol use disorder Patients Open
The data used for construction of AMI was from two clinical trials approved by the Regional Ethics Committee of Uppsala, Sweden and performed in accordance with the Declaration of Helsinki. Written informed consent was obtained from all pa…
View article: Aquaporin gene therapy corrects Sjögren’s syndrome phenotype in mice
Aquaporin gene therapy corrects Sjögren’s syndrome phenotype in mice Open
Significance Recent reports of increases in the prevalence and incidence of autoimmune diseases make this disease group a pressing public health concern. Patients suffering from Sjögren’s syndrome experience debilitating oral and ocular dr…