Fred Rincón
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View article: In-hospital Mortality is Lower in Brain-Injured Patients After Admission to a Neuroscience Intensive Care Unit: A Multi-Center Cohort Study
In-hospital Mortality is Lower in Brain-Injured Patients After Admission to a Neuroscience Intensive Care Unit: A Multi-Center Cohort Study Open
Objective To study the impact of dedicated Neuroscience Intensive Care Units (NSU) on clinical outcomes in patients with acute brain injury. Design Retrospective, multicenter cohort study. Setting 172 intensive care units within the United…
View article: Hypothermia and temperature modulation for intracerebral hemorrhage (ICH): pathophysiology and translational applications
Hypothermia and temperature modulation for intracerebral hemorrhage (ICH): pathophysiology and translational applications Open
Background Intracerebral hemorrhage (ICH) still poses a substantial challenge in clinical medicine because of the high morbidity and mortality rate that characterizes it. This review article expands into the complex pathophysiological proc…
View article: Implementation and impact of a point of care electroencephalography platform in a community hospital: a cohort study
Implementation and impact of a point of care electroencephalography platform in a community hospital: a cohort study Open
Objective To determine the clinical and financial feasibility of implementing a poc-EEG system in a community hospital. Design Data from a prospective cohort displaying abnormal mentation concerning for NCSE or rhythmic movements due to po…
View article: Consensus recommendations on therapeutic hypothermia after minimally invasive intracerebral hemorrhage evacuation from the hypothermia for intracerebral hemorrhage (HICH) working group
Consensus recommendations on therapeutic hypothermia after minimally invasive intracerebral hemorrhage evacuation from the hypothermia for intracerebral hemorrhage (HICH) working group Open
Background and purpose Therapeutic hypothermia (TH), or targeted temperature management (TTM), is a classic treatment option for reducing inflammation and potentially other destructive processes across a wide range of pathologies, and has …
View article: Longitudinal transcriptomics define the stages of myeloid activation in the living human brain after intracerebral hemorrhage
Longitudinal transcriptomics define the stages of myeloid activation in the living human brain after intracerebral hemorrhage Open
RNA sequencing of cerebral hematoma myeloid cells reveals a two-stage functional and metabolic program associated with recovery.
View article: Management of Acute Ischemic Stroke
Management of Acute Ischemic Stroke Open
Objectives: Concise “synthetic” review of the state of the art of management of acute ischemic stroke. Data Sources: Available literature on PubMed. Study Selection: We selected landmark studies, recent clinical trials, observational studi…
View article: Status of SARS-CoV-2 in cerebrospinal fluid of patients with COVID-19 and stroke
Status of SARS-CoV-2 in cerebrospinal fluid of patients with COVID-19 and stroke Open
Background Emergence of the novel corona virus (severe acute respiratory syndrome (SARS)-CoV-2) in December 2019 has led to the COVID-19 pandemic. The extent of COVID-19 involvement in the central nervous system is not well established, an…
View article: Diagnostic Accuracy of Procalcitonin in Differentiating Sepsis from Noninfectious SIRS in Adult Patients with Subarachnoid Hemorrhage
Diagnostic Accuracy of Procalcitonin in Differentiating Sepsis from Noninfectious SIRS in Adult Patients with Subarachnoid Hemorrhage Open
Background: Subarachnoid hemorrhage (SAH) is a frequent diagnosis in the neuro-intensive care unit (NICU) that can result in the development of systemic inflammatory response syndrome (SIRS) and fever. The differentiation between central f…
View article: Neurological Critical Care Services’ Influence Following Large Hemispheric Infarction and Their Impact on Resource Utilization
Neurological Critical Care Services’ Influence Following Large Hemispheric Infarction and Their Impact on Resource Utilization Open
Introduction: Acute ischemic stroke (AIS) is the fourth leading cause of death in the US. Numerous studies have demonstrated the use of comprehensive stroke units and neurological intensive care units (NICU) in improving outcomes after str…
View article: Neurological Critical Care Services' Influence Following Large Hemispheric Infarction and Their Impact on Resource Utilization.
Neurological Critical Care Services' Influence Following Large Hemispheric Infarction and Their Impact on Resource Utilization. Open
The data suggest that in LHI-patients requiring mechanical ventilation, a dedicated NCC service reduces the overall need for tracheostomy, increases Vfd, and decreases ICU and hospital-LOS.
View article: Secondary Hematoma Expansion and Perihemorrhagic Edema after Intracerebral Hemorrhage: From Bench Work to Practical Aspects
Secondary Hematoma Expansion and Perihemorrhagic Edema after Intracerebral Hemorrhage: From Bench Work to Practical Aspects Open
Intracerebral hemorrhages (ICH) represent about 10-15% of all strokes per year in the United States alone. Key variables influencing the long-term outcome after ICH are hematoma size and growth. Although death may occur at the time of the …
View article: Early Ambulation in Patients with External Ventrical Drains: Results of a Quality Improvement Project
Early Ambulation in Patients with External Ventrical Drains: Results of a Quality Improvement Project Open
Introduction Prolonged immobility in ICU patients can lead to muscle wasting and weakness, longer hospital stays, increased number of days in restraints and hospital acquired infections. Increasing evidence demonstrates the safety and feas…
View article: Utility of Biomarkers in the Evaluation of Fever in the Intensive Care Unit After Brain Injury
Utility of Biomarkers in the Evaluation of Fever in the Intensive Care Unit After Brain Injury Open
Fever is frequent in patients with neurologic injury. Differentiating infectious fever from central fever can be challenging. It is important to diagnose the cause of fever in the neurological intensive care unit because of the detrimental…
View article: Status Epilepticus: Epidemiology and Public Health Needs
Status Epilepticus: Epidemiology and Public Health Needs Open
Status epilepticus (SE) is defined as a continuous clinical and/or electrographic seizure activity lasting five minutes or more or recurrent seizure activity without return to baseline. There is a paucity of epidemiological studies of SE, …
View article: Beta-blocker therapy and impact on outcome after aneurysmal subarachnoid hemorrhage: a cohort study
Beta-blocker therapy and impact on outcome after aneurysmal subarachnoid hemorrhage: a cohort study Open
OBJECTIVE Cerebral vasospasm (cVSP) is a frequent complication of aneurysmal subarachnoid hemorrhage (aSAH), with a significant impact on outcome. Beta blockers (BBs) may blunt the sympathetic effect and catecholamine surge associated with…
View article: Novel Therapies for Intracerebral Hemorrhage
Novel Therapies for Intracerebral Hemorrhage Open
INTRODUCTION Intracerebral hemorrhage is by far the most destructive form of stroke1. Apart from the management in a specialized stroke or neurological intensive care unit (NICU), no specific therapies have been shown to consistently impro…
View article: Dabigatran-Associated Intracranial Hemorrhage
Dabigatran-Associated Intracranial Hemorrhage Open
Dabigatran etexilate is an oral direct thrombin inhibitor approved for prevention of stroke and systemic embolization in patients with nonvalvular atrial fibrillation and for the treatment of venous thromboembolism. Although dabigatran has…