Fred Sawe
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View article: Knowledge, attitudes and practices related to SARS-CoV-2 prevention in Kenya
Knowledge, attitudes and practices related to SARS-CoV-2 prevention in Kenya Open
Background: Knowledge, attitudes, and practices (KAPs) regarding severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) non-pharmaceutical interventions (NPIs) may differ among populations with health vulnerabilities. Aim: To examine…
View article: Bayesian estimation of HIV acquisition dates for prevention trials
Bayesian estimation of HIV acquisition dates for prevention trials Open
Accurate timing estimates of when participants acquire HIV in HIV prevention trials are necessary for determining antibody levels at acquisition. The Antibody-Mediated Prevention (AMP) Studies showed that a passively administered broadly n…
View article: Limited awareness and use of HIV post‐exposure prophylaxis among people vulnerable to HIV acquisition in Western Kenya: a cross‐sectional analysis
Limited awareness and use of HIV post‐exposure prophylaxis among people vulnerable to HIV acquisition in Western Kenya: a cross‐sectional analysis Open
Introduction HIV post‐exposure prophylaxis (PEP) can prevent HIV acquisition and facilitates linkage to pre‐exposure prophylaxis (PrEP) for people with ongoing vulnerability. We assessed PEP awareness and use in Western Kenya. Methods We u…
View article: Pre‐exposure prophylaxis implementation gaps among people vulnerable to HIV acquisition: a cross‐sectional analysis in two communities in western Kenya, 2021–2023
Pre‐exposure prophylaxis implementation gaps among people vulnerable to HIV acquisition: a cross‐sectional analysis in two communities in western Kenya, 2021–2023 Open
Introduction Despite the increasing availability of prevention tools like pre‐exposure prophylaxis (PrEP), HIV incidence remains disproportionately high in sub‐Saharan Africa. We examined PrEP awareness, uptake and persistence among partic…
View article: 1552. HIV Pre-Exposure Prophylaxis Awareness, Uptake, and Persistence Among People at Risk for HIV in Two Communities in Western Kenya
1552. HIV Pre-Exposure Prophylaxis Awareness, Uptake, and Persistence Among People at Risk for HIV in Two Communities in Western Kenya Open
Background Despite the increasing availability of evidenced-based HIV prevention tools like pre-exposure prophylaxis (PrEP), HIV incidence remains disproportionately high in sub-Saharan Africa, especially among key populations. To inform t…
View article: Association between severe anaemia and inflammation, risk of IRIS and death in persons with HIV: A multinational cohort study
Association between severe anaemia and inflammation, risk of IRIS and death in persons with HIV: A multinational cohort study Open
View article: HIV-1 infections with multiple founders associate with the development of neutralization breadth
HIV-1 infections with multiple founders associate with the development of neutralization breadth Open
Eliciting broadly neutralizing antibodies (bnAbs) is a cornerstone of HIV-1 vaccine strategies. Comparing HIV-1 envelope (env) sequences from the first weeks of infection to the breadth of antibody responses observed several years after in…
View article: Impact of the Relationship between Anaemia and Systemic Inflammation on the Risk of Incident Tuberculosis and Death in Persons with Advanced HIV: A Sub-Analysis of the REMEMBER Trial
Impact of the Relationship between Anaemia and Systemic Inflammation on the Risk of Incident Tuberculosis and Death in Persons with Advanced HIV: A Sub-Analysis of the REMEMBER Trial Open
View article: Factors influencing estimates of HIV-1 infection timing using BEAST
Factors influencing estimates of HIV-1 infection timing using BEAST Open
While large datasets of HIV-1 sequences are increasingly being generated, many studies rely on a single gene or fragment of the genome and few comparative studies across genes have been done. We performed genome-based and gene-specific Bay…
View article: The Frequency of Malaria Is Similar among Women Receiving either Lopinavir/Ritonavir or Nevirapine-based Antiretroviral Treatment
The Frequency of Malaria Is Similar among Women Receiving either Lopinavir/Ritonavir or Nevirapine-based Antiretroviral Treatment Open
HIV protease inhibitors (PIs) show antimalarial activity in vitro and in animals. Whether this translates into a clinical benefit in HIV-infected patients residing in malaria-endemic regions is unknown. We studied the incidence of malaria,…
View article: An Inflammatory Composite Score Predicts Mycobacterial Immune Reconstitution Inflammatory Syndrome in People with Advanced HIV: A Prospective International Cohort Study
An Inflammatory Composite Score Predicts Mycobacterial Immune Reconstitution Inflammatory Syndrome in People with Advanced HIV: A Prospective International Cohort Study Open
Background Immune reconstitution inflammatory syndrome (IRIS) is a common cause of morbidity among people with human immunodeficiency virus (PWH) who initiate antiretroviral therapy (ART) with severe lymphopenia. Easily accessible tools th…
Molecular dating and viral load growth rates suggested that the eclipse phase lasted about a week in HIV-1 infected adults in East Africa and Thailand Open
View article: Linked dual-class HIV resistance mutations are associated with treatment failure
Linked dual-class HIV resistance mutations are associated with treatment failure Open
We hypothesized that HIV-1 with dual-class but not single-class drug resistance mutations linked on the same viral genome, present in the virus population before initiation of antiretroviral therapy (ART), would be associated with failure …
View article: Combining Viral Genetics and Statistical Modeling to Improve HIV-1 Time-of-Infection Estimation towards Enhanced Vaccine Efficacy Assessment
Combining Viral Genetics and Statistical Modeling to Improve HIV-1 Time-of-Infection Estimation towards Enhanced Vaccine Efficacy Assessment Open
Knowledge of the time of HIV-1 infection and the multiplicity of viruses that establish HIV-1 infection is crucial for the in-depth analysis of clinical prevention efficacy trial outcomes. Better estimation methods would improve the abilit…
View article: Pregnancy outcomes among HIV-infected women who conceived on antiretroviral therapy
Pregnancy outcomes among HIV-infected women who conceived on antiretroviral therapy Open
As antiretroviral therapy (ART) expands in resource-limited settings, understanding the impact of ART on pregnancy outcomes is critical. We analyzed women who became pregnant on ART while enrolled in a clinical trial (HPTN 052, ACTG A5208,…
View article: Prospective Study of Acute HIV-1 Infection in Adults in East Africa and Thailand
Prospective Study of Acute HIV-1 Infection in Adults in East Africa and Thailand Open
The viral-load set point occurred at a median of 31 days after the first detection of plasma viremia and correlated with peak viremia. Few symptoms and signs were observed during acute HIV-1 infection, and they were most common before peak…