Frédéric Aubrun
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View article: Individual mHLA-DR trajectories in the ICU as predictors of early infections following liver transplantation: a prospective observational study
Individual mHLA-DR trajectories in the ICU as predictors of early infections following liver transplantation: a prospective observational study Open
Our findings highlight mHLA-DR as an early predictor of post-LT infections. Monitoring post-LT immune function through mHLA-DR expression could guide individualized management strategies to improve outcomes. Trial registration The study wa…
View article: Distinct phenotypes of patients and healthcare resource utilization after hospitalization for COVID-19: an observational study
Distinct phenotypes of patients and healthcare resource utilization after hospitalization for COVID-19: an observational study Open
Based on HCU data, AHC identified 8 clinically relevant profiles of patients surviving the acute episode of COVID-19 hospitalization. The clusters illustrate the many impacts of COVID on the health status of infected patients and may help …
View article: Individual mHLA-DR trajectories in the ICU as predictors of early infections following liver transplantation: a prospective observational study
Individual mHLA-DR trajectories in the ICU as predictors of early infections following liver transplantation: a prospective observational study Open
Background Infections are a leading cause of early mortality after liver transplantation (LT). Prior to transplantation, cirrhosis-associated immune dysfunction significantly increases the risk of infection. This study investigated the pot…
View article: Are Healthcare Resource Utilization Patterns for Pain Management Specific to Post-Acute COVID-19 Syndrome? A Study of Survivors from the First French Pandemic Wave
Are Healthcare Resource Utilization Patterns for Pain Management Specific to Post-Acute COVID-19 Syndrome? A Study of Survivors from the First French Pandemic Wave Open
Objectives: Chronic pain is a common symptom in Post-Acute COVID-19 Syndrome (PACS), affecting 11–60% of patients, but the link between COVID-19 and chronic pain remains unclear. This study assesses healthcare resource utilization (HRU) fo…
View article: Health Care Resource Use and Total Mortality After Hospital Admission for Severe COVID-19 Infections During the Initial Pandemic Wave in France: Descriptive Study
Health Care Resource Use and Total Mortality After Hospital Admission for Severe COVID-19 Infections During the Initial Pandemic Wave in France: Descriptive Study Open
Background Little is known about post–hospital health care resource use (HRU) of patients admitted for severe COVID-19, specifically for the care of patients with postacute COVID-19 syndrome (PACS). Objective A list of HRU domains and item…
View article: Occurrences of post-traumatic stress disorder, anxiety, depression, and burnout syndrome in ICU staff workers after two-year of the COVID-19 pandemic: the international PSY-CO in ICU study
Occurrences of post-traumatic stress disorder, anxiety, depression, and burnout syndrome in ICU staff workers after two-year of the COVID-19 pandemic: the international PSY-CO in ICU study Open
Purpose The present study aimed at assessing the prevalences of post-traumatic stress disorder (PTSD) (main objective), anxiety, depression, and burnout syndrome (BOS) and their associated factors in intensive care unit (ICU) staff workers…
View article: Chronic pain characteristics in COVID-19 survivors after an ICU stay. A cross-sectional study
Chronic pain characteristics in COVID-19 survivors after an ICU stay. A cross-sectional study Open
View article: Impact of COVID-19 pandemic on antifungal consumption: a multicenter retrospective analysis
Impact of COVID-19 pandemic on antifungal consumption: a multicenter retrospective analysis Open
View article: Perioperative Outcomes in Patients Who Received Spinal Chloroprocaine for Total Hip or Knee Arthroplasty—Consecutive Case Series Study
Perioperative Outcomes in Patients Who Received Spinal Chloroprocaine for Total Hip or Knee Arthroplasty—Consecutive Case Series Study Open
Spinal anaesthesia is an established component of perioperative management for fast-track lower limbs arthroplasty. Short-acting local anaesthetics may present an interesting option for primary non-complicated knee (TKA) and hip (THA) arth…
View article: Virological and clinical features of acute respiratory failure associated with COVID-19 in pregnancy: a case-control study.
Virological and clinical features of acute respiratory failure associated with COVID-19 in pregnancy: a case-control study. Open
Objective: Pregnancy is a risk factor for acute respiratory failure (ARF) following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We hypothesised that SARS-CoV-2 viral load in the respiratory tract might be…
View article: Preoperative Education for Less Outpatient Pain after Surgery (PELOPS trial) in orthopedic patients—study protocol for a randomized controlled trial
Preoperative Education for Less Outpatient Pain after Surgery (PELOPS trial) in orthopedic patients—study protocol for a randomized controlled trial Open
View article: Preoperative Anxiety in the Surgical Transfer and Waiting Area: A Cross-Sectional Mixed Method Study
Preoperative Anxiety in the Surgical Transfer and Waiting Area: A Cross-Sectional Mixed Method Study Open
Severe preoperative anxiety (SPA) in surgical patients may have clinical consequences and worsen satisfaction. Some institutions have a surgical transfer and waiting area (TWA) for patient reception/dispatch to operating rooms. We measured…
View article: Impact of COVID-19 on chronic pain structures: data from French national survey
Impact of COVID-19 on chronic pain structures: data from French national survey Open
Aims: The authors evaluated the impact of the first COVID-19 pandemic wave on French chronic pain structures (CPS). Methods: An online survey assessed CPS resource allocation, workflow and perceived impact on patient care. Results: All CPS…
View article: Nefopam prescribing preferences in French hospitals: results of a survey
Nefopam prescribing preferences in French hospitals: results of a survey Open
oral prescription of intravenous formulation of nefopam is frequent, especially for acute pain, and has the same dose and regimen pattern as for intravenous route. Prescribers consider oral nefopam efficient and safe for patients. Regulato…
View article: Coxiella burnetti prosthetic joint infection in an immunocompromised woman: iterative surgeries, prolonged ofloxacin-rifampin treatment and complex reconstruction were needed for the cure
Coxiella burnetti prosthetic joint infection in an immunocompromised woman: iterative surgeries, prolonged ofloxacin-rifampin treatment and complex reconstruction were needed for the cure Open
View article: Pharmacokinetic modeling of morphine and its glucuronides: Comparison of nebulization versus intravenous route in healthy volunteers
Pharmacokinetic modeling of morphine and its glucuronides: Comparison of nebulization versus intravenous route in healthy volunteers Open
Intravenous (i.v.) morphine is a safe, robust, and recommended treatment for severe pain using the titration principle. Despite its high efficacy, it is impacted by organizational constraints related to venous access. Nebulized (NEB) morph…
View article: Association between voriconazole exposure and Sequential Organ Failure Assessment (SOFA) score in critically ill patients
Association between voriconazole exposure and Sequential Organ Failure Assessment (SOFA) score in critically ill patients Open
Therapeutic drug monitoring (TDM) is essential for voriconazole to ensure optimal drug exposure, mainly in critically ill patients for whom voriconazole demonstrated a large variability. The study aimed at describing factors associated wit…
View article: Open-label randomized controlled trial of ultra-low tidal ventilation without extracorporeal circulation in patients with COVID-19 pneumonia and moderate to severe ARDS: study protocol for the VT4COVID trial
Open-label randomized controlled trial of ultra-low tidal ventilation without extracorporeal circulation in patients with COVID-19 pneumonia and moderate to severe ARDS: study protocol for the VT4COVID trial Open
View article: Short- and long-term prognosis of acute critically ill patients with systemic rheumatic diseases
Short- and long-term prognosis of acute critically ill patients with systemic rheumatic diseases Open
Patients with systemic rheumatic disease (SRD) share the risks of multi-organ flare-up, cardiovascular diseases, and immunosuppression. Such situations can lead to an acute critical illness. The present study describes the clinical feature…
View article: Burden of critically ill patients with influenza in a French catchment population
Burden of critically ill patients with influenza in a French catchment population Open
View article: Neuromuscular monitoring and neuromuscular blocking agent shortages when treating critically ill COVID-19 patients: a multicentre retrospective analysis
Neuromuscular monitoring and neuromuscular blocking agent shortages when treating critically ill COVID-19 patients: a multicentre retrospective analysis Open
View article: Pourquoi la kétamine ?
Pourquoi la kétamine ? Open
Douleur & Analgésie, première revue internationale francophone consacrée à la douleur, dont le champ de son expertise s'étend de la recherche fondamentale à la clinique tant sur le plan de l'évaluation de la douleur que de ses traitements.
View article: Population pharmacokinetics of daptomycin in patients with bone and joint infection: minimal effect of rifampicin co-administration and confirmation of a sex difference
Population pharmacokinetics of daptomycin in patients with bone and joint infection: minimal effect of rifampicin co-administration and confirmation of a sex difference Open
Background Daptomycin is increasingly used in the treatment of bone and joint infection (BJI), but its pharmacokinetics (PK) and dosage requirements have not been thoroughly investigated in this indication. Daptomycin may be co-administere…
View article: Supplementary Material for: Extracorporeal Albumin Dialysis in Liver Failure with MARS and SPAD: A Randomized Crossover Trial
Supplementary Material for: Extracorporeal Albumin Dialysis in Liver Failure with MARS and SPAD: A Randomized Crossover Trial Open
Introduction: Liver failure is associated with hepatic and extrahepatic organ failure leading to a high short-term mortality rate. Extracorporeal albumin dialysis (ECAD) aims to reduce albumin-bound toxins accumulated during …
View article: Management of postdischarge nausea and vomiting
Management of postdischarge nausea and vomiting Open
View article: Surgical activity during the Covid-19 pandemic: Results for 112 patients in a French tertiary care center, a quality improvement study
Surgical activity during the Covid-19 pandemic: Results for 112 patients in a French tertiary care center, a quality improvement study Open
We found that the performance of oncological or emergency surgery is possible, safe for both patients and caregivers.
View article: Evaluation of first-line therapies for the treatment of candidemia in ICU patients: A propensity score analysis
Evaluation of first-line therapies for the treatment of candidemia in ICU patients: A propensity score analysis Open
View article: Evaluation of the effectiveness and tolerance of tetracosactide in the treatment of post-dural puncture headaches (ESYBRECHE): a study protocol for a randomised controlled trial
Evaluation of the effectiveness and tolerance of tetracosactide in the treatment of post-dural puncture headaches (ESYBRECHE): a study protocol for a randomised controlled trial Open
Background Post-dural puncture headache (PDPH) is one of the most common complications of neuraxial anaesthesia. It limits patients’ general activity and increases the length of hospital stays and the use of care. It is particularly disabl…
View article: Anemia before reimplantation surgery
Anemia before reimplantation surgery Open
Introduction : Preoperative anemia in patients undergoing a two-stage septic revision arthroplasty may be a factor of reinfection, even in the presence of aggressive antimicrobial therapy. Patient Blood Management (PBM) in such patients is…
View article: Hepatopulmonary Syndrome and Post-Liver Transplantation Complications: A Case-Control Study.
Hepatopulmonary Syndrome and Post-Liver Transplantation Complications: A Case-Control Study. Open
HPS patients seem to have a higher number of complications in the first month following LT.