Frédéric Bolze
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View article: Novel Azole-Modified Porphyrins for Mitochondria-Targeted Photodynamic Therapy
Novel Azole-Modified Porphyrins for Mitochondria-Targeted Photodynamic Therapy Open
Photodynamic therapy is a non-invasive treatment strategy for various types of cancer, based on the use of light to activate a photosensitizer which triggers processes leading to cell death. Given the increasing interest in the development…
View article: Robust Photocleavable Linkers for DNA Synthesis: Enabling Visible Light-Triggered Antisense Oligonucleotide Release in 3D DNA Nanocages
Robust Photocleavable Linkers for DNA Synthesis: Enabling Visible Light-Triggered Antisense Oligonucleotide Release in 3D DNA Nanocages Open
We synthesized new para-dialkylaminonitrobiphenyl (ANBP) derivatives, s-ANBP and t-ANBP, functionalized with dimethyltrityl and phosphoramidite groups for incorporation into DNA backbones as photocleavable linkers via solid-phase synthesis…
View article: Triplet‐Triplet Annihilation Upconversion‐Based Photolysis: Applications in Photopharmacology
Triplet‐Triplet Annihilation Upconversion‐Based Photolysis: Applications in Photopharmacology Open
The emerging field of photopharmacology is a promising chemobiological methodology for optical control of drug activities that could ultimately solve the off‐target toxicity outside the disease location of many drugs for the treatment of a…
View article: Photoactivatable Liposomes for Blue to Deep Red Light-Activated Surface Drug Release: Application to Controlled Delivery of the Antitumoral Drug Melphalan
Photoactivatable Liposomes for Blue to Deep Red Light-Activated Surface Drug Release: Application to Controlled Delivery of the Antitumoral Drug Melphalan Open
Liposome-based nanoparticles able to release, via a photolytic reaction, a payload anchored at the surface of the phospholipid bilayer were prepared. The liposome formulation strategy uses an original drug-conjugated blue light-sensitive p…
View article: Ultrabright two-photon excitable red-emissive fluorogenic probes for fast and wash-free bioorthogonal labeling in live cells
Ultrabright two-photon excitable red-emissive fluorogenic probes for fast and wash-free bioorthogonal labeling in live cells Open
Fluorogenic bioorthogonal reactions are promising tools for tracking small molecules or biomolecules in living organisms. Two-photon excitation, by shifting absorption towards the red, significantly increases the signal-to-noise ratio and …
View article: Ultrabright two-photon excitable red-emissive fluorogenic probes for fast and wash-free bioorthogonal labeling in live cells
Ultrabright two-photon excitable red-emissive fluorogenic probes for fast and wash-free bioorthogonal labeling in live cells Open
Fluorogenic bioorthogonal reactions are promising tools for tracking small molecules or biomolecules in living organisms. Two-photon excitation, by shifting absorption towards the red, significantly increases the signal-to-noise ratio and …
View article: Ultrabright two-photon excitable red-emissive fluorogenic probes for fast and wash-free bioorthogonal labelling in live cells
Ultrabright two-photon excitable red-emissive fluorogenic probes for fast and wash-free bioorthogonal labelling in live cells Open
Our best fluorogenic probe enables live-cell imaging with high-contrast and no need for washing steps.
View article: Wavelength-Dependent, Orthogonal Photoregulation of DNA Liberation for Logic Operations
Wavelength-Dependent, Orthogonal Photoregulation of DNA Liberation for Logic Operations Open
In this study, we synthesized two phosphoramidites based on 2,7-bis-{4-nitro-8-[3-(2-propyl)-styryl]}-9,9-bis-[1-(3,6-dioxaheptyl)]-fluorene (BNSF) and 4,4'-bis-{8-[4-nitro-3-(2-propyl)-styryl]}-3,3'-di-methoxybiphenyl (BNSMB) structures a…
View article: Red Light‐Responsive Upconverting Nanoparticles for Quantitative and Controlled Release of a Coumarin‐Based Prodrug
Red Light‐Responsive Upconverting Nanoparticles for Quantitative and Controlled Release of a Coumarin‐Based Prodrug Open
Photolytic reactions allow the optical control of the liberation of biological effectors by photolabile protecting groups. The development of versatile technologies enabling the use of deep‐red or NIR light excitation still represents a ch…
View article: On the Road Toward More Efficient Biocompatible Two‐Photon Excitable Fluorophores
On the Road Toward More Efficient Biocompatible Two‐Photon Excitable Fluorophores Open
Red‐to‐NIR absorption and emission wavelengths are key requirements for intravital bioimaging. One of the way to reach such excitation wavelengths is to use two‐photon excitation. Unfortunately, there is still a lack of two‐photon excitabl…
View article: Two-Photon Sensitive Coumarinyl Photoremovable Protecting Groups with Rigid Electron-Rich Cycles Obtained by Domino Reactions Initiated by a 5-<i>exo</i>-Dig Cyclocarbopalladation
Two-Photon Sensitive Coumarinyl Photoremovable Protecting Groups with Rigid Electron-Rich Cycles Obtained by Domino Reactions Initiated by a 5-<i>exo</i>-Dig Cyclocarbopalladation Open
We herein report the design, synthesis, and photophysical characterization of extended and rigid coumarinyl derivatives showing large two-photon sensitivities (δaΦu ≤ 125 GM) at 740 and 800 nm. To efficiently synthesize these complex photo…
View article: Correction to “Multimodal Theranostic Cyanine-Conjugated Gadolinium(III) Complex for <i>In Vivo</i> Imaging of Amyloid-β in Alzheimer’s Disease Mouse Model”
Correction to “Multimodal Theranostic Cyanine-Conjugated Gadolinium(III) Complex for <i>In Vivo</i> Imaging of Amyloid-β in Alzheimer’s Disease Mouse Model” Open
ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to "Multimodal Theranostic Cyanine-Conjugated Gadolinium(III) Complex for In Vivo Imaging of Amyloid-β in Alzheimer's Disease Mou…
View article: Synthesis and In Vitro Studies of a Gd(DOTA)–Porphyrin Conjugate for Combined MRI and Photodynamic Treatment
Synthesis and In Vitro Studies of a Gd(DOTA)–Porphyrin Conjugate for Combined MRI and Photodynamic Treatment Open
With the aim of developing new molecular theranostic agents, a π-extended Zn(II) porphyrin as photosensitizer for photodynamic therapy (PDT) linked to two GdDOTA-type complexes for magnetic resonance imaging (MRI) detection was synthesized…
View article: Tumour-targeting photosensitisers for one- and two-photon activated photodynamic therapy
Tumour-targeting photosensitisers for one- and two-photon activated photodynamic therapy Open
Efficient receptor-mediated delivery of a folate-targeted photosensitiser to kill cancer cells following two-photon excitation in the near-infrared is demonstrated.
View article: A Porphyrin Dimer–GdDOTA Conjugate as a Theranostic Agent for One- and Two-Photon Photodynamic Therapy and MRI
A Porphyrin Dimer–GdDOTA Conjugate as a Theranostic Agent for One- and Two-Photon Photodynamic Therapy and MRI Open
A molecular theranostic agent designed for photodynamic therapy (PDT) treatment in the near-infrared and for imaging tissue tumors with magnetic resonance imaging (MRI) is reported. It consists of a linear π-conjugated Zn(II) porphyrin dim…
View article: Synthesis and Characterization of Photoactivatable Doxycycline Analogues Bearing Two‐Photon‐Sensitive Photoremovable Groups Suitable for Light‐Induced Gene Expression
Synthesis and Characterization of Photoactivatable Doxycycline Analogues Bearing Two‐Photon‐Sensitive Photoremovable Groups Suitable for Light‐Induced Gene Expression Open
We report the synthesis and photolytic properties of caged 9‐aminodoxycycline derivatives modified with 2‐{4′‐bis‐[2‐(2methoxyethoxy)ethyl]‐4‐nitrobiphenyl‐3‐yl}prop‐1‐oxy (EANBP) and PEG7‐ylated (7‐diethylamino‐2‐oxo‐2 H ‐chromen‐4‐yl)met…
View article: <i>o</i>-Nitrobenzyl photoremovable groups with fluorescence uncaging reporting properties
<i>o</i>-Nitrobenzyl photoremovable groups with fluorescence uncaging reporting properties Open
o-Nitrobenzyl photoremovable groups are able to generate a fluorescent uncaging side-product.
View article: π-extended porphyrin dimers as efficient near-infrared emitters and two-photon absorbers
π-extended porphyrin dimers as efficient near-infrared emitters and two-photon absorbers Open
A Zn-porphyrin dimer and its linear conjugate with two diketopyrrolopyrrole (DPP) units have been prepared and their one- and two-photon photophysical properties have been characterised. The already wide conjugation of the dimer is further…
View article: Molecular photosensitisers for two-photon photodynamic therapy
Molecular photosensitisers for two-photon photodynamic therapy Open
With the recent development of clinical two-photon microscopes or endoscopes, new photosensitisers for two-photon photodynamic therapy are the subject of increasing interest. Herein, we review the advances within the ten last years of mole…
View article: Two-photon uncaging, from neuroscience to materials
Two-photon uncaging, from neuroscience to materials Open
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View article: Four Gadolinium(III) Complexes Appended to a Porphyrin: A Water-Soluble Molecular Theranostic Agent with Remarkable Relaxivity Suited for MRI Tracking of the Photosensitizer
Four Gadolinium(III) Complexes Appended to a Porphyrin: A Water-Soluble Molecular Theranostic Agent with Remarkable Relaxivity Suited for MRI Tracking of the Photosensitizer Open
A molecular theranostic agent for magnetic resonance imaging (MRI) and photodynamic therapy (PDT) consisting of four [GdDTTA](-) complexes (DTTA(4-) = diethylenetriamine-N,N,N″,N″-tetraacetate) linked to a meso-tetraphenylporphyrin core, a…
View article: Live-Cell One- and Two-Photon Uncaging of a Far-Red Emitting Acridinone Fluorophore
Live-Cell One- and Two-Photon Uncaging of a Far-Red Emitting Acridinone Fluorophore Open
Total synthesis and photophysical properties of PENB-DDAO, a photoactivatable 1,3-dichloro-9,9-dimethyl-9H-acridin-2(7)-one (DDAO) derivative of a far-red emitting fluorophore, are described. The photoremovable group of the DDAO phenolic f…
View article: A Theranostic Agent Combining a Two‐Photon‐Absorbing Photosensitizer for Photodynamic Therapy and a Gadolinium(III) Complex for MRI Detection
A Theranostic Agent Combining a Two‐Photon‐Absorbing Photosensitizer for Photodynamic Therapy and a Gadolinium(III) Complex for MRI Detection Open
The convergent synthesis and characterization of a potential theranostic agent, [DPP‐ZnP‐GdDOTA] − , which combines a diketopyrrolopyrrole‐porphyrin component DPP‐ZnP as a two‐photon photosensitizer for photodynamic therapy (PDT) with a ga…
View article: Fluorescent Tobacco mosaic virus-Derived Bio-Nanoparticles for Intravital Two-Photon Imaging
Fluorescent Tobacco mosaic virus-Derived Bio-Nanoparticles for Intravital Two-Photon Imaging Open
Multi-photon intravital imaging has become a powerful tool to investigate the healthy and diseased brain vasculature in living animals. Although agents for multi-photon fluorescence microscopy of the microvasculature are available, issues …
View article: CCDC 1451986: Experimental Crystal Structure Determination
CCDC 1451986: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: π-Extended diketopyrrolopyrrole–porphyrin arrays: one- and two-photon photophysical investigations and theoretical studies
π-Extended diketopyrrolopyrrole–porphyrin arrays: one- and two-photon photophysical investigations and theoretical studies Open
Diketopyrrolopyrrole–porphyrin conjugates show remarkable NIR emission properties, high two-photon absorption cross-sections and significant singlet oxygen production efficiency.