Catherine Picart
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View article: CABaNe, an automated, high content ImageJ macro for cell and neurite analysis
CABaNe, an automated, high content ImageJ macro for cell and neurite analysis Open
Measuring neurite length is crucial in neurobiology because it provides valuable insights into the growth, development, and function of neurons. In particular, neurite length is fundamental to study neuronal development and differentiation…
View article: Development of an automated high‐content immunofluorescence assay of pSmads quantification: Proof‐of‐concept with drugs inhibiting the BMP/TGF‐β pathways
Development of an automated high‐content immunofluorescence assay of pSmads quantification: Proof‐of‐concept with drugs inhibiting the BMP/TGF‐β pathways Open
Introduction Bone morphogenetic proteins (BMPs) and transforming growth factors (TGF‐β) are members of the TGF‐β superfamily, known for their roles in several physiological and pathological processes. These factors are known to bind in viv…
View article: Biomimetic materials presenting extracellular matrix components to study bone morphogenetic protein bioactivity
Biomimetic materials presenting extracellular matrix components to study bone morphogenetic protein bioactivity Open
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View article: Impact of heterozygous ALK1 mutations on the transcriptomic response to BMP9 and BMP10 in endothelial cells from hereditary hemorrhagic telangiectasia and pulmonary arterial hypertension donors
Impact of heterozygous ALK1 mutations on the transcriptomic response to BMP9 and BMP10 in endothelial cells from hereditary hemorrhagic telangiectasia and pulmonary arterial hypertension donors Open
Heterozygous activin receptor-like kinase 1 ( ALK1 ) mutations are associated with two vascular diseases: hereditary hemorrhagic telangiectasia (HHT) and more rarely pulmonary arterial hypertension (PAH). Here, we aimed to understand the i…
View article: Recent Developments in Layer‐by‐Layer Assembly for Drug Delivery and Tissue Engineering Applications
Recent Developments in Layer‐by‐Layer Assembly for Drug Delivery and Tissue Engineering Applications Open
Surfaces with biological functionalities are of great interest for biomaterials, tissue engineering, biophysics, and for controlling biological processes. The layer‐by‐layer (LbL) assembly is a highly versatile methodology introduced 30 ye…
View article: Development of an automated high-content immuno-fluorescence assay of pSmads quantification: proof-of-concept with drugs inhibiting the BMP/TGFβ pathways
Development of an automated high-content immuno-fluorescence assay of pSmads quantification: proof-of-concept with drugs inhibiting the BMP/TGFβ pathways Open
Bone morphogenetic proteins (BMPs) and transforming growth factors (TGF-β) are members of the transforming growth factors superfamily, known for their role in several physiological and pathological processes. These factors are known to bin…
View article: Sweet but Challenging: Tackling the Complexity of GAGs with Engineered Tailor‐Made Biomaterials
Sweet but Challenging: Tackling the Complexity of GAGs with Engineered Tailor‐Made Biomaterials Open
Glycosaminoglycans (GAGs) play a crucial role in tissue homeostasis by regulating the activity and diffusion of bioactive molecules. Incorporating GAGs into biomaterials has emerged as a widely adopted strategy in medical applications, owi…
View article: Cell-type-specific control of secondary cell wall formation by Musashi-type translational regulators in Arabidopsis
Cell-type-specific control of secondary cell wall formation by Musashi-type translational regulators in Arabidopsis Open
Deciphering the mechanism of secondary cell wall/SCW formation in plants is key to understanding their development and the molecular basis of biomass recalcitrance. Although transcriptional regulation is essential for SCW formation, little…
View article: Cell type-specific control of secondary cell wall formation by Musashi-type translational regulators in Arabidopsis
Cell type-specific control of secondary cell wall formation by Musashi-type translational regulators in Arabidopsis Open
Deciphering the mechanism of secondary cell wall/SCW formation in plants is key to understanding their development and the molecular basis of biomass recalcitrance. Although transcriptional regulation is essential for SCW formation, little…
View article: Author Response: Cell type-specific control of secondary cell wall formation by Musashi-type translational regulators in Arabidopsis
Author Response: Cell type-specific control of secondary cell wall formation by Musashi-type translational regulators in Arabidopsis Open
Deciphering the mechanism of secondary cell wall/SCW formation in plants is key to understanding their development and the molecular basis of biomass recalcitrance. Although transcriptional regulation is essential for SCW formation, little…
View article: 3D‐Printed Osteoinductive Polymeric Scaffolds with Optimized Architecture to Repair a Sheep Metatarsal Critical‐Size Bone Defect
3D‐Printed Osteoinductive Polymeric Scaffolds with Optimized Architecture to Repair a Sheep Metatarsal Critical‐Size Bone Defect Open
The reconstruction of critical‐size bone defects in long bones remains a challenge for clinicians. A new osteoinductive medical device is developed here for long bone repair by combining a 3D‐printed architectured cylindrical scaffold made…
View article: Cell type-specific control of secondary cell wall formation by Musashi-type translational regulators in Arabidopsis
Cell type-specific control of secondary cell wall formation by Musashi-type translational regulators in Arabidopsis Open
Deciphering the mechanism of secondary cell wall/SCW formation in plants is key to understanding their development and the molecular basis of biomass recalcitrance. Although transcriptional regulation is essential for SCW formation, little…
View article: Cell-type-specific control of secondary cell wall formation by Musashi-type translational regulators in Arabidopsis
Cell-type-specific control of secondary cell wall formation by Musashi-type translational regulators in Arabidopsis Open
Deciphering the mechanism of secondary cell wall/SCW formation in plants is key to understanding their development and the molecular basis of biomass recalcitrance. Although transcriptional regulation is essential for SCW formation, little…
View article: Cell type-specific control of secondary cell wall formation by Musashi-type translational regulators in Arabidopsis
Cell type-specific control of secondary cell wall formation by Musashi-type translational regulators in Arabidopsis Open
Deciphering the mechanism of secondary cell wall/SCW formation in plants is key to understanding their development and the molecular basis of biomass recalcitrance. Although transcriptional regulation is essential for SCW formation, little…
View article: Interplay between integrins and cadherins to control bone differentiation upon BMP-2 stimulation
Interplay between integrins and cadherins to control bone differentiation upon BMP-2 stimulation Open
Introduction: Upon BMP-2 stimulation, the osteoblastic lineage commitment in C2C12 myoblasts is associated with a microenvironmental change that occurs over several days. How does BMP-2 operate a switch in adhesive machinery to adapt to th…
View article: 3D-printed polymeric scaffolds with optimized architecture to repair a sheep metatarsal critical-size bone defect
3D-printed polymeric scaffolds with optimized architecture to repair a sheep metatarsal critical-size bone defect Open
The reconstruction of critical-size bone defects in long bones remains a challenge for clinicians. We developed a new bioactive medical device for long bone repair by combining a 3D-printed architectured cylindrical scaffold made of clinic…
View article: Integrin-based adhesion compartmentalizes ALK3 of the BMPRII to control cell adhesion and migration
Integrin-based adhesion compartmentalizes ALK3 of the BMPRII to control cell adhesion and migration Open
The spatial organization of cell-surface receptors is fundamental for the coordination of biological responses to physical and biochemical cues of the extracellular matrix. How serine/threonine kinase receptors, ALK3-BMPRII, cooperate with…
View article: Automated Fabrication of Streptavidin-Based Self-assembled Materials for High-Content Analysis of Cellular Response to Growth Factors
Automated Fabrication of Streptavidin-Based Self-assembled Materials for High-Content Analysis of Cellular Response to Growth Factors Open
The automation of liquid-handling routines offers great potential for fast, reproducible, and labor-reduced biomaterial fabrication but also requires the development of special protocols. Competitive systems demand for a high degree in min…
View article: Combining Fluorescence Fluctuations and Photobleaching to Quantify Surface Density
Combining Fluorescence Fluctuations and Photobleaching to Quantify Surface Density Open
We have established a self-calibrated method, called pbFFS for photobleaching fluctuation fluorescence spectroscopy, which aims to characterize molecules or particles labeled with an unknown distribution of fluorophores. Using photobleachi…
View article: Engineering of a Microscale Niche for Pancreatic Tumor Cells Using Bioactive Film Coatings Combined with 3D-Architectured Scaffolds
Engineering of a Microscale Niche for Pancreatic Tumor Cells Using Bioactive Film Coatings Combined with 3D-Architectured Scaffolds Open
Two-photon polymerization has recently emerged as a promising technique to fabricate scaffolds for three-dimensional (3D) cell culture and tissue engineering. Here, we combined 3D-printed microscale scaffolds fabricated using two-photon po…
View article: Combining fluorescence fluctuations and photobleaching to quantify\n surface density
Combining fluorescence fluctuations and photobleaching to quantify\n surface density Open
We establish a method, called pbFFS for photobleaching Fluctuation\nFluorescence Spectroscopy, which aims at characterizing molecules or particles\nlabelled with a unknown distribution or fluorophores. Using photobleaching as a\ncontrol pa…
View article: Combining fluorescence fluctuations and photobleaching to quantify surface density
Combining fluorescence fluctuations and photobleaching to quantify surface density Open
We establish a method, called pbFFS for photobleaching Fluctuation Fluorescence Spectroscopy, which aims at characterizing molecules or particles labelled with a unknown distribution or fluorophores. Using photobleaching as a control param…
View article: ANCHOR: A Technical Approach to Monitor Single-Copy Locus Localization in Planta
ANCHOR: A Technical Approach to Monitor Single-Copy Locus Localization in Planta Open
Together with local chromatin structure, gene accessibility, and the presence of transcription factors, gene positioning is implicated in gene expression regulation. Although the basic mechanisms are expected to be conserved in eukaryotes,…
View article: LARP6C orchestrates posttranscriptional reprogramming of gene expression during hydration to promote pollen tube guidance
LARP6C orchestrates posttranscriptional reprogramming of gene expression during hydration to promote pollen tube guidance Open
Increasing evidence suggests that posttranscriptional regulation is a key player in the transition between mature pollen and the progamic phase (from pollination to fertilization). Nonetheless, the actors in this messenger RNA (mRNA)-based…
View article: High-throughput measurements of bone morphogenetic protein/bone morphogenetic protein receptor interactions using biolayer interferometry
High-throughput measurements of bone morphogenetic protein/bone morphogenetic protein receptor interactions using biolayer interferometry Open
Bone morphogenetic proteins (BMPs) are an important family of growth factors playing a role in a large number of physiological and pathological processes, including bone homeostasis, tissue regeneration, and cancers. In vivo, BMPs bind suc…