Fréderic Duprez
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View article: Late Toxicity and Long‐Term Quality of Life in Survivors of Cancer of the Major Salivary Glands More Than 5 Years After Diagnosis: A Multi‐National Study
Late Toxicity and Long‐Term Quality of Life in Survivors of Cancer of the Major Salivary Glands More Than 5 Years After Diagnosis: A Multi‐National Study Open
Background Because salivary gland cancers (SGC) are rare and include different tumor subtypes, data on their long‐term quality of life and late toxicities are sparse. Methods Multi‐national study including SGC survivors more than 5 years a…
View article: Toxicities in long‐term survivors of head and neck cancer—A multi‐national cross‐sectional analysis
Toxicities in long‐term survivors of head and neck cancer—A multi‐national cross‐sectional analysis Open
Head and neck cancer (HNC) patients may experience toxicities as a result of their treatment modality. While acute toxicities have been well documented, the prevalence of toxicities at long‐term follow‐up of HNC survivors is less clear. As…
View article: Exploratory Research: Patient‐Reported Factors Contributing to Decreased Oral Intake During Radiotherapy in Head and Neck Cancer
Exploratory Research: Patient‐Reported Factors Contributing to Decreased Oral Intake During Radiotherapy in Head and Neck Cancer Open
Background Radiotherapy (RT) in head and neck cancer (HNC) can cause multiple side effects such as nausea, pain, taste loss, fatigue, oral mucositis, xerostomia, and acute radiation‐associated dysphagia (RAD). These factors threaten patien…
View article: Recurrent clear cell odontogenic carcinoma initially diagnosed as ameloblastoma: A case report and review of literature
Recurrent clear cell odontogenic carcinoma initially diagnosed as ameloblastoma: A case report and review of literature Open
Clear cell odontogenic carcinoma (CCOC) is a rare, malignant tumor primarily affecting the mandible in middle-aged women, known to be highly recurrent post-surgery. A 56-year-old female, with an initial diagnosis of ameloblastoma based on …
View article: Long‐term health‐related quality of life in head and neck cancer survivors: A large multinational study
Long‐term health‐related quality of life in head and neck cancer survivors: A large multinational study Open
Head and neck cancer (HNC) patients suffer from a range of health‐related quality of life (HRQoL) issues, but little is known about their long‐term HRQoL. This study explored associations between treatment group and HRQoL at least 5 years'…
View article: Incidence and radiotherapy treatment patterns of complicated bone metastases
Incidence and radiotherapy treatment patterns of complicated bone metastases Open
Approximately 37 % of bone metastases are classified as complicated with the majority related to (impending) fracture. Patients with complicated bone metastases have a median survival of 4 months and were mostly treated with SFRT.
View article: Large-scale meta–genome-wide association study reveals common genetic factors linked to radiation-induced acute toxicities across cancer types
Large-scale meta–genome-wide association study reveals common genetic factors linked to radiation-induced acute toxicities across cancer types Open
Background This study was designed to identify common genetic susceptibility and shared genetic variants associated with acute radiation-induced toxicity across 4 cancer types (prostate, head and neck, breast, and lung). Methods A genome-w…
View article: Checkpoint Inhibitors in Combination With Stereotactic Body Radiotherapy in Patients With Advanced Solid Tumors
Checkpoint Inhibitors in Combination With Stereotactic Body Radiotherapy in Patients With Advanced Solid Tumors Open
Importance Although immune checkpoint inhibitors (ICIs) targeting programmed cell death 1 (PD-1) and PD-1 ligand 1 have improved the outcome for many cancer types, the majority of patients fails to respond to ICI monotherapy. Hypofractiona…
View article: Supportive care among head and neck cancer patients: An initial validation of the Dutch version of the Performance Status Scale for Head and Neck Cancer (D‐PSS‐HN)
Supportive care among head and neck cancer patients: An initial validation of the Dutch version of the Performance Status Scale for Head and Neck Cancer (D‐PSS‐HN) Open
Background Acute and late toxicities in patients treated with (chemo)radiotherapy for head and neck cancer (HNC) is common and can negatively impact quality of life and performance. Performance status instruments measure the functional abi…
View article: Serious Long-Term Effects of Head and Neck Cancer from the Survivors’ Point of View
Serious Long-Term Effects of Head and Neck Cancer from the Survivors’ Point of View Open
The long-term problems of head and neck cancer survivors (HNCS) are not well known. In a cross-sectional international study aimed at exploring the long-term quality of life in this population, 1114 HNCS were asked to state their two most …
View article: Clinical presentation of sporadic and hereditary pheochromocytoma/paraganglioma
Clinical presentation of sporadic and hereditary pheochromocytoma/paraganglioma Open
Pheochromocytomas (PHEO) and paragangliomas (PGL) can occur sporadic or within genetic predisposition syndromes. Despite shared embryology, there are important differences between PHEO and PGL. The aim of this study was to describe the cli…
View article: Supportive Care Among Head and Neck Cancer Patients: Validation of the Dutch Version of the Oral Mucositis Weekly Questionnaire—Head and Neck Cancer
Supportive Care Among Head and Neck Cancer Patients: Validation of the Dutch Version of the Oral Mucositis Weekly Questionnaire—Head and Neck Cancer Open
Objective: Oral mucositis is one of the most profound toxicities during (chemo)radiotherapy for head and neck cancer, impacting a patient's quality of life. To measure the effect of oral mucositis on one's quality of life, the use of patie…
View article: Concordance, Correlation, and Clinical Impact of Standardized PD-L1 and TIL Scoring in SCCHN
Concordance, Correlation, and Clinical Impact of Standardized PD-L1 and TIL Scoring in SCCHN Open
Background: The clinical significance of tumor-infiltrating lymphocytes (TILs) and programmed cell death-ligand 1 (PD-L1) expression has been thoroughly researched in squamous cell carcinoma of the head and neck (SCCHN). To address the imp…
View article: An open‐label, nonrandomized, phase Ib feasibility study of cusatuzumab in patients with nasopharyngeal carcinoma
An open‐label, nonrandomized, phase Ib feasibility study of cusatuzumab in patients with nasopharyngeal carcinoma Open
CD70 is expressed in up to 80% of nasopharyngeal carcinoma (NPC) cases. Cusatuzumab is a humanized anti‐CD70 monoclonal antibody, with dual action mechanisms: induction of cytotoxicity against CD70 + tumor cells and reduction in CD70‐CD27 …