Frédéric Gagnadoux
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View article: Unravelling telemonitoring data to predict good NIV quality: the E-QualiNIV study
Unravelling telemonitoring data to predict good NIV quality: the E-QualiNIV study Open
Background and objective High treatment quality, defined by mean adherence >4 hours per day, unintentional leaks <24 L/min and a residual Apnoea–Hypopnoea Index <5 events per hour, is associated with better outcomes. Adherence variance may…
View article: Positive Airway Pressure-Related Aerophagia in Obstructive Sleep Apnea: Results from the InterfaceVent Real-Life Study
Positive Airway Pressure-Related Aerophagia in Obstructive Sleep Apnea: Results from the InterfaceVent Real-Life Study Open
Background: Continuous positive airway pressure (CPAP) effectiveness can be compromised by adverse effects. Despite its potential impact on adherence and sleepiness, aerophagia remains under-recognized and poorly characterized. This ancill…
View article: Concerns arising from the calculation of the apnea-hypopnea index during CPAP-telemonitoring of patients with obstructive sleep apnea
Concerns arising from the calculation of the apnea-hypopnea index during CPAP-telemonitoring of patients with obstructive sleep apnea Open
Our proof-of-concept study highlights inconsistencies in AHIflow calculations among CPAP manufacturers, raising concerns about patient care. Establishing standardized AHIflow calculation criteria is essential to ensur…
View article: NLRP3, conveyed via extracellular vesicles from metabolic syndrome patients, is involved in atherosclerosis development
NLRP3, conveyed via extracellular vesicles from metabolic syndrome patients, is involved in atherosclerosis development Open
Our data demonstrate that NLRP3-inflammasome, carried by EVs, is actively involved in vascular inflammation and atherosclerosis development in MetS. We highlight NLRP3 carried by EVs as potential biomarker and target for potential therapeu…
View article: NLRP3, conveyed via extracellular vesicles from metabolic syndrome patients, is involved in atherosclerosis development
NLRP3, conveyed via extracellular vesicles from metabolic syndrome patients, is involved in atherosclerosis development Open
Background Inappropriate activation of the Nod-like receptor protein 3 (NLRP3)-inflammasome contributes to atherosclerosis progression and plaque instability in patients with cardiovascular events. However, its role in the atherosclerosis …
View article: 0715 A Prospective, Multicenter, Real-world Study on the Long-Term Effectiveness of a CAD/CAM 3D-Printed Oral Appliance to Treat OSA: An Update
0715 A Prospective, Multicenter, Real-world Study on the Long-Term Effectiveness of a CAD/CAM 3D-Printed Oral Appliance to Treat OSA: An Update Open
Introduction Oral appliance therapy (OAT) for treating obstructive sleep apnea (OSA) is one of the cornerstones of OSA management and requires multidisciplinary care management. When complete, the study will provide data on the use of the …
View article: Association of positive airway pressure adherence with use of antihypertensive drugs in patients with sleep apnoea
Association of positive airway pressure adherence with use of antihypertensive drugs in patients with sleep apnoea Open
Background The impact of positive airway pressure (PAP) therapy on the use of oral antihypertensive drugs (OAHDs) in patients with obstructive sleep apnoea (OSA) remains unclear. This study aimed to evaluate the association between PAP use…
View article: Relevance of telemonitoring algorithms for the management of home noninvasive ventilation
Relevance of telemonitoring algorithms for the management of home noninvasive ventilation Open
Background The increasing number of patients requiring home noninvasive ventilation (HNIV) is a challenge for our healthcare system. Telemonitoring may be used to facilitate the management of HNIV patients. We aimed to assess the ability o…
View article: The influence of atmospheric temperature on long-term CPAP-usage in patients with obstructive sleep apnea
The influence of atmospheric temperature on long-term CPAP-usage in patients with obstructive sleep apnea Open
View article: Constraints to the initiation of home non-invasive ventilation and short-term efficacy in different diagnostic groups (as a prelude to an ambulatory shift)
Constraints to the initiation of home non-invasive ventilation and short-term efficacy in different diagnostic groups (as a prelude to an ambulatory shift) Open
Each aetiological group has specific constraints in the initiation of NIV that should be considered when initiating NIV in the outpatient setting.
View article: Change in Sleep Quality Associated With Adaptive Servoventilation for Central Sleep Apnea
Change in Sleep Quality Associated With Adaptive Servoventilation for Central Sleep Apnea Open
View article: Evaluating the Benefit of Home Support Provider Services for Positive Airway Pressure Therapy in Patients With Obstructive Sleep Apnea: Protocol for an Ambispective International Real-World Study
Evaluating the Benefit of Home Support Provider Services for Positive Airway Pressure Therapy in Patients With Obstructive Sleep Apnea: Protocol for an Ambispective International Real-World Study Open
Background Adherence and persistence to positive airway pressure (PAP) therapy are key factors for positive health outcomes. Home support providers participate in the home implementation and follow-up of PAP therapy for patients with obstr…
View article: Reversible pulmonary arterial hypertension induced by bosutinib: a case report
Reversible pulmonary arterial hypertension induced by bosutinib: a case report Open
In patients with chronic myeloid leukaemia and no pre-existing dasatinib-induced cardiovascular complication, exposure to bosutinib may lead to severe pulmonary arterial hypertension that is potentially reversible upon cessation of trea…
View article: Circulating extracellular vesicle-carried PTP1B and PP2A phosphatases as regulators of insulin resistance
Circulating extracellular vesicle-carried PTP1B and PP2A phosphatases as regulators of insulin resistance Open
Aims/hypothesis Metabolic disorders associated with abdominal obesity, dyslipidaemia, arterial hypertension and hyperglycaemia are risk factors for the development of insulin resistance. Extracellular vesicles (EVs) may play an important r…
View article: Effect of telemonitoring on the rate of dropout during home non-invasive ventilation: a retrospective study using a home care provider database
Effect of telemonitoring on the rate of dropout during home non-invasive ventilation: a retrospective study using a home care provider database Open
Objectives Telemonitoring (TM) of home non-invasive ventilation (NIV) has been shown to facilitate home/outpatient therapy set-up. However, the impact of long-term TM on therapy dropouts, compliance and leak control has not yet been clearl…
View article: Mask side-effects are related to gender in long-term CPAP: results from the InterfaceVent real-life study
Mask side-effects are related to gender in long-term CPAP: results from the InterfaceVent real-life study Open
View article: Association Between Healthy Behaviors and Health Care Resource Use With Subsequent Positive Airway Pressure Therapy Adherence in OSA
Association Between Healthy Behaviors and Health Care Resource Use With Subsequent Positive Airway Pressure Therapy Adherence in OSA Open
This study indicated that patients who adhere to PAP therapy for OSA were more health-seeking and used less health care resources prior to device initiation than patients who were nonadherent. Until the healthy adherer effect associated wi…
View article: Chronic cough in patients with obstructive sleep apnoea: A prospective cohort study
Chronic cough in patients with obstructive sleep apnoea: A prospective cohort study Open
International audience
View article: The PAP-RES algorithm: Defining who, why and how to use positive airway pressure therapy for OSA
The PAP-RES algorithm: Defining who, why and how to use positive airway pressure therapy for OSA Open
Obstructive sleep apnea (OSA) is a common condition that is increasing in prevalence worldwide. Untreated OSA has a negative impact on health-related quality of life and is an independent risk factor for cardiovascular diseases. Despite av…
View article: Guidelines for the assessment and management of residual sleepiness in obstructive apnea-hypopnea syndrome
Guidelines for the assessment and management of residual sleepiness in obstructive apnea-hypopnea syndrome Open
View article: Small Extracellular Vesicles Harboring PD-L1 in Obstructive Sleep Apnea
Small Extracellular Vesicles Harboring PD-L1 in Obstructive Sleep Apnea Open
Obstructive sleep apnea syndrome (OSA) has been associated with increased cancer incidence and aggressiveness. One hypothesis to support this association is the implication of immune response, particularly the programmed cell death pathway…
View article: CT Imaging Assessment of Response to Treatment in Allergic Bronchopulmonary Aspergillosis in Adults With Bronchial Asthma
CT Imaging Assessment of Response to Treatment in Allergic Bronchopulmonary Aspergillosis in Adults With Bronchial Asthma Open
View article: Seasonal changes in positive airway pressure adherence
Seasonal changes in positive airway pressure adherence Open
Through their effects on sleep duration, bedroom environments, and pollen allergies, seasonal variations may impact positive airway pressure (PAP) adherence. We analyzed daily PAP telemonitoring data from 25,846 adults (median age 64 years…
View article: Similarities and differences of interstitial lung disease associated with pathogenic variants in <scp><i>SFTPC</i></scp> and <scp><i>ABCA3</i></scp> in adults
Similarities and differences of interstitial lung disease associated with pathogenic variants in <span><i>SFTPC</i></span> and <span><i>ABCA3</i></span> in adults Open
Background and Objective Variants in surfactant genes SFTPC or ABCA3 are responsible for interstitial lung disease (ILD) in children and adults, with few studies in adults. Methods We conducted a multicentre retrospective study of all cons…
View article: Does PaCO2 correction have an impact on survival of patients with chronic respiratory failure and long-term non-invasive ventilation?
Does PaCO2 correction have an impact on survival of patients with chronic respiratory failure and long-term non-invasive ventilation? Open
View article: The need for coordinating efforts to improve the global evidence of the long-term effectiveness of adult obstructive sleep apnea surgical therapies
The need for coordinating efforts to improve the global evidence of the long-term effectiveness of adult obstructive sleep apnea surgical therapies Open
View article: OC 11.2 Pulmonary Embolism Diagnostic Strategies in Patients with COPD Exacerbation: Post-Hoc Analysis of the Pep Trial
OC 11.2 Pulmonary Embolism Diagnostic Strategies in Patients with COPD Exacerbation: Post-Hoc Analysis of the Pep Trial Open
model, as determined by SHAP analysis. Conclusion(s):Machine learning models using clinical data in EHRs can accurately predict VTE in diverse ancestry populations.
View article: A biphasic effect of age on CPAP adherence: a cross-sectional study of 26,343 patients
A biphasic effect of age on CPAP adherence: a cross-sectional study of 26,343 patients Open
View article: PD-L1+ small extracellular vesicles in obstructive sleep apnea syndrome
PD-L1+ small extracellular vesicles in obstructive sleep apnea syndrome Open
Obstructive sleep apnea syndrome (OSA) has been associated with increased cancer incidence and aggressiveness. One hypothesis to support this association is the implication of immune response, particularly the programmed cell death pathway…
View article: Recommandations pour le bilan et la prise en charge de la somnolence résiduelle dans le syndrome d’apnées-hypopnées obstructives du sommeil
Recommandations pour le bilan et la prise en charge de la somnolence résiduelle dans le syndrome d’apnées-hypopnées obstructives du sommeil Open