Frederic Grabowski
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View article: Quantifying cancer- and drug-induced changes in Shannon information capacity of RTK signaling
Quantifying cancer- and drug-induced changes in Shannon information capacity of RTK signaling Open
Cancer can result from abnormal regulation of cells by their environment, potentially because cancer cells may misperceive environmental cues. However, the magnitude to which the oncogenic state alters cellular information processing has n…
View article: Quantifying cancer- and drug-induced changes in Shannon information capacity of RTK signaling
Quantifying cancer- and drug-induced changes in Shannon information capacity of RTK signaling Open
Signaling pathways transmit and process information, enabling cells to respond accurately to external cues. Disease states like cancer can corrupt signal transmission, though the magnitude to which they reduce information capacity has not …
View article: Information transmission in a cell monolayer: A numerical study
Information transmission in a cell monolayer: A numerical study Open
Motivated by the spatiotemporal waves of MAPK/ERK activity, crucial for long-range communication in regenerating tissues, we investigated stochastic homoclinic fronts propagating through channels formed by directly interacting cells. We ev…
View article: Type III interferons may suppress viral infections by triggering cell death
Type III interferons may suppress viral infections by triggering cell death Open
Type III interferons (IFN-λ1–λ4) are known to limit influenza virus infections in vivo and are non-redundant to type I interferons (IFN-α and IFN-β). Here, we demonstrate that IFN-λ acts through mechanisms that are beyond its ability to in…
View article: Information transmission in a cell monolayer: A numerical study
Information transmission in a cell monolayer: A numerical study Open
Motivated by the spatiotemporal waves of MAPK/ERK activity, crucial for long-range communication in regenerating tissues, we investigated stochastic homoclinic fronts propagating through channels formed by directly interacting cells. We ev…
View article: On the Properties and Estimation of Pointwise Mutual Information Profiles
On the Properties and Estimation of Pointwise Mutual Information Profiles Open
The pointwise mutual information profile, or simply profile, is the distribution of pointwise mutual information for a given pair of random variables. One of its important properties is that its expected value is precisely the mutual infor…
View article: Antagonism between viral infection and innate immunity at the single-cell level
Antagonism between viral infection and innate immunity at the single-cell level Open
When infected with a virus, cells may secrete interferons (IFNs) that prompt nearby cells to prepare for upcoming infection. Reciprocally, viral proteins often interfere with IFN synthesis and IFN-induced signaling. We modeled the crosstal…
View article: Predictive power of non-identifiable models
Predictive power of non-identifiable models Open
Resolving practical non-identifiability of computational models typically requires either additional data or non-algorithmic model reduction, which frequently results in models containing parameters lacking direct interpretation. Here, ins…
View article: Beyond Normal: On the Evaluation of Mutual Information Estimators
Beyond Normal: On the Evaluation of Mutual Information Estimators Open
Mutual information is a general statistical dependency measure which has found applications in representation learning, causality, domain generalization and computational biology. However, mutual information estimators are typically evalua…
View article: Predictive power of non-identifiable models
Predictive power of non-identifiable models Open
Resolving practical nonidentifiability of computational models typically requires either additional data or non-algorithmic model reduction, which frequently results in models containing parameters lacking direct interpretation. Here, inst…
View article: Antagonism between viral infection and innate immunity at the single-cell level
Antagonism between viral infection and innate immunity at the single-cell level Open
When infected with a virus, cells may secrete interferons (IFNs) that prompt nearby cells to prepare for upcoming infection. Reciprocally, viral proteins often interfere with IFN synthesis and IFN-induced signaling. We modeled the crosstal…
View article: The Spread of SARS-CoV-2 Variant Omicron with a Doubling Time of 2.0–3.3 Days Can Be Explained by Immune Evasion
The Spread of SARS-CoV-2 Variant Omicron with a Doubling Time of 2.0–3.3 Days Can Be Explained by Immune Evasion Open
Omicron, the novel highly mutated SARS-CoV-2 Variant of Concern (VOC, Pango lineage B.1.1.529) was first collected in early November 2021 in South Africa. By the end of November 2021, it had spread and approached fixation in South Africa, …
View article: The spread of SARS-CoV-2 variant Omicron with the doubling time of 2.0–3.3 days can be explained by immune evasion
The spread of SARS-CoV-2 variant Omicron with the doubling time of 2.0–3.3 days can be explained by immune evasion Open
Omicron, the novel highly mutated SARS-CoV-2 Variant of Concern (VOC, Pango lineage B.1.1.529), was first collected in early November 2021 in South Africa. By the end of November 2021, it had spread and approached fixation in South Africa,…
View article: SARS-CoV-2 Variant of Concern 202012/01 Has about Twofold Replicative Advantage and Acquires Concerning Mutations
SARS-CoV-2 Variant of Concern 202012/01 Has about Twofold Replicative Advantage and Acquires Concerning Mutations Open
The novel SARS-CoV-2 Variant of Concern (VOC)-202012/01 (also known as B.1.1.7), first collected in United Kingdom on 20 September 2020, is a rapidly growing lineage that in January 2021 constituted 86% of all SARS-CoV-2 genomes sequenced …
View article: Review 1: "Estimated transmissibility and severity of novel SARS-CoV-2 Variant of Concern 202012/01 in England"
Review 1: "Estimated transmissibility and severity of novel SARS-CoV-2 Variant of Concern 202012/01 in England" Open
View article: L18F substrain of SARS-CoV-2 VOC-202012/01 is rapidly spreading in England
L18F substrain of SARS-CoV-2 VOC-202012/01 is rapidly spreading in England Open
The Variant of Concern (VOC)-202012/01 (also known as B.1.1.7) is a rapidly growing lineage of SARS-CoV-2. In January 2021, VOC-202012/01 constituted about 80% of SARS-CoV-2 genomes sequenced in England and was present in 27 out of 29 coun…
View article: Reviews of "Estimated transmissibility and severity of novel SARS-CoV-2 Variant of Concern 202012/01 in England"
Reviews of "Estimated transmissibility and severity of novel SARS-CoV-2 Variant of Concern 202012/01 in England" Open
Reviewers: Tomasz Lipniacki, Frederic Grabowski, Marek KochaÅczyk (Institute of Fundamental Technological Research) | ðððâ»ï¸â»ï¸ ⢠Seyed Hasnain (Jamia Hamdard) | ðððâ»ï¸â»ï¸
View article: SARS-CoV-2 Variant of Concern 202012/01 has about twofold replicative advantage and acquires concerning mutations
SARS-CoV-2 Variant of Concern 202012/01 has about twofold replicative advantage and acquires concerning mutations Open
The novel SARS-CoV-2 Variant of Concern (VOC)-202012/01 (also known as B.1.1.7), first collected in United Kingdom on September 20, 2020, is a rapidly growing lineage that in January 2021 constituted 86% of all SARS-CoV-2 genomes sequenced…
View article: Super-spreading events initiated the exponential growth phase of COVID-19 with ℛ <sub>0</sub> higher than initially estimated
Super-spreading events initiated the exponential growth phase of COVID-19 with ℛ <sub>0</sub> higher than initially estimated Open
The basic reproduction number of the coronavirus disease 2019 has been estimated to range between 2 and 4. Here, we used an SEIR model that properly accounts for the distribution of the latent period and, based on empirical estimates…
View article: Super-spreading events initiated the exponential growth phase of COVID-19 with ℛ<sub>0</sub> higher than initially estimated
Super-spreading events initiated the exponential growth phase of COVID-19 with ℛ<sub>0</sub> higher than initially estimated Open
The basic reproduction number ℛ 0 of the coronavirus disease 2019 has been estimated to range between 2 and 4. Here we used a SEIR model that properly accounts for the distribution of the latent period and, based on empirical estimates of …
View article: Dynamics of COVID-19 pandemic at constant and time-dependent contact rates
Dynamics of COVID-19 pandemic at constant and time-dependent contact rates Open
We constructed a simple Susceptible–Infected–Infectious–Excluded model of the spread of COVID-19. The model is parametrised only by the average incubation period, τ , and two rate parameters: contact rate, r C , and exclusion rate, r E . T…
View article: Dynamics of COVID-19 pandemic at constant and time-dependent contact rates
Dynamics of COVID-19 pandemic at constant and time-dependent contact rates Open
We constructed a simple Susceptible−Exposed–Infectious–Removed model of the spread of COVID-19. The model is parametrised only by the average incubation period, τ , and two rate parameters: contact rate, β , and exclusion rate, γ . The rat…
View article: Asymptotic safety and conformal standard model
Asymptotic safety and conformal standard model Open
We show that the Conformal Standard Model supplemented with asymptotically\nsafe gravity can be valid up to arbitrarily high energies and give a complete\ndescription of particle physics phenomena. We restrict the mass of the second\nscala…
View article: Limits to the rate of information transmission through the MAPK pathway
Limits to the rate of information transmission through the MAPK pathway Open
Two important signalling pathways of NF-κB and ERK transmit merely 1 bit of information about the level of extracellular stimulation. It is thus unclear how such systems can coordinate complex cell responses to external cues. We analyse in…
View article: Limits to the rate of information transmission through MAPK pathway
Limits to the rate of information transmission through MAPK pathway Open
Two important signaling pathways of NF-κB and ERK transmit merely one bit of information about the level of extracellular stimulation. It is thus unclear how such systems can coordinate complex cell responses to external cues. Here, we ana…