Frédéric Lagarce
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View article: Expert opinion on extrusion-based pharmaceutical 3D printing from the European Society of Hospital Pharmaceutical Technology (GERPAC)
Expert opinion on extrusion-based pharmaceutical 3D printing from the European Society of Hospital Pharmaceutical Technology (GERPAC) Open
Three-dimensional (3D) printing technologies have been applied to manufacture a variety of medicinal products. This emerging technology holds significant potential in pharmaceutical applications, offering innovative solutions for both pati…
View article: Automated Non-Sterile Pharmacy Compounding: A Multi-Site Study in European Hospital and Community Pharmacies with Pediatric Immediate Release Propranolol Hydrochloride Tablets
Automated Non-Sterile Pharmacy Compounding: A Multi-Site Study in European Hospital and Community Pharmacies with Pediatric Immediate Release Propranolol Hydrochloride Tablets Open
Pharmacy compounding, the art and science of preparing customized medications to meet individual patient needs, is on the verge of transformation. Traditional methods of compounding often involve manual and time-consuming processes, presen…
View article: Elimination study of intact lipid nanocapsules after intravenous rat administration
Elimination study of intact lipid nanocapsules after intravenous rat administration Open
Aim: The present study investigated renal elimination after intravenous administration of four different formulations of lipid nanocapsules (LNCs) containing dyes adapted to Förster resonance energy transfer (FRET-LNCs). Materials & method…
View article: Automated Non-Sterile Pharmacy Compounding: A Multi-Site Study in European Hospital and Community Pharmacies with Pediatric Immediate Release Propranolol Hydrochloride Tablets
Automated Non-Sterile Pharmacy Compounding: A Multi-Site Study in European Hospital and Community Pharmacies with Pediatric Immediate Release Propranolol Hydrochloride Tablets Open
Pharmacy compounding, the art and science of preparing customized medications to meet individual patient needs, is in a verge of transformation. Traditional methods of compounding often involve manual and time-consuming processes, presenti…
View article: Impact of the COVID-19 pandemic on drug-related issues and pharmacist interventions in geriatric acute care units
Impact of the COVID-19 pandemic on drug-related issues and pharmacist interventions in geriatric acute care units Open
To assess and compare the activity of pharmaceutical analysis on drug management in a geriatric acute care unit prior to and during the COVID-19 pandemic. This was a single-centre, observational, retrospective, and comparative cohort study…
View article: Recommendations on training objectives and staff qualification for the manual preparation of capsules in pharmacy
Recommendations on training objectives and staff qualification for the manual preparation of capsules in pharmacy Open
Training and certification of personnel in capsule preparation are essential procedures, overseen by the pharmacist who delegates these tasks. These procedures aim not only to ensure the efficacy and safety of operations but also to establ…
View article: In vitro evaluation of acute and chronic liver toxicity of lipid nanocapsules: what formulation for a better biocompatibility?
In vitro evaluation of acute and chronic liver toxicity of lipid nanocapsules: what formulation for a better biocompatibility? Open
International audience
View article: New liquid oral formulations of hydroxychloroquine: a physicochemical stability study
New liquid oral formulations of hydroxychloroquine: a physicochemical stability study Open
Objectives Hydroxychloroquine (HCQ) presents many drug properties that increase its therapeutic use. There are, indeed, different research pathways in numerous autoimmune, inflammatory, and infectious diseases, as well as in cancerology. H…
View article: GERPAC Consensus Conference – Guidance on the Assignment of Microbiological Shelf-life for Hospital Pharmacy Aseptic Preparations
GERPAC Consensus Conference – Guidance on the Assignment of Microbiological Shelf-life for Hospital Pharmacy Aseptic Preparations Open
All dosage forms prepared in hospital pharmacies should be labelled with an appropriate shelf-life. This shelf-life should be validated taking chemical, physical and microbiological data into consideration. This guidance focuses on parente…
View article: Methods for the Study of Physical and Chemical Stability and Container-Content Interactions: Report of a GERPAC Workshop
Methods for the Study of Physical and Chemical Stability and Container-Content Interactions: Report of a GERPAC Workshop Open
This opinion paper describes the discussions of the attendees of the last GERPAC European conference workshop on the question of chemical stability and container-content interactions. Pharmacists discussed the steps to implement to carry o…
View article: <p>Di-<em>O</em>-lauroyl-decitabine-lipid nanocapsules: toward extending decitabine activity</p>
Di-<em>O</em>-lauroyl-decitabine-lipid nanocapsules: toward extending decitabine activity Open
Decitabine (C12)2 as a prodrug showed high encapsulation efficiency, a good stability in plasma with no impact on its activity on leukemia cells and improved pharmacokinetics.
View article: Stability of a 50 mg/mL Ceftazidime Eye-Drops Formulation
Stability of a 50 mg/mL Ceftazidime Eye-Drops Formulation Open
Background Microbial keratitis are severe infectionsgenerally linked to risk factors. High-doses antibiotic eye-drops could be required to avoid severe complications. In such cases, hospital pharmacists are in charge of their production gi…
View article: After Ten Issues Our Journal Has Found Its Audience and Main Topics
After Ten Issues Our Journal Has Found Its Audience and Main Topics Open
International audience
View article: Absence of lung fibrosis after a single pulmonary delivery of lipid nanocapsules in rats
Absence of lung fibrosis after a single pulmonary delivery of lipid nanocapsules in rats Open
Lipid nanocapsules (LNCs) are potential drug carriers for pulmonary delivery since they can be nebulized without any structural or functional changes, and the aerosols produced are highly compatible with pulmonary drug delivery in human be…
View article: Development and in vitro evaluations of new decitabine nanocarriers for the treatment of acute myeloid leukemia
Development and in vitro evaluations of new decitabine nanocarriers for the treatment of acute myeloid leukemia Open
Decitabine is a hydrophilic drug that acts by hypomethylating DNA. Decitabine is used in Europe for the treatment of acute myeloid leukemia (AML) in patients aged ≥65 years. However, it can only be administered intravenously due to very lo…
View article: Centrally Prepared Cytotoxic Drugs: What Is the Purpose of Their Quality Control?
Centrally Prepared Cytotoxic Drugs: What Is the Purpose of Their Quality Control? Open
To assess the quality of centrally prepared cytotoxics a global approach is being implemented by pharmacists. A risk analysis is performed, and then many in-process controls are proposed. The aseptic process and the material are also fully…