Frédéric Leblond
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View article: A Comprehensive Review of Margin Identification Methods in Soft Tissue Sarcoma
A Comprehensive Review of Margin Identification Methods in Soft Tissue Sarcoma Open
Soft tissue sarcomas (STS) are rare and heterogeneous tumors for which achieving complete tumor resection with negative surgical margins remains the cornerstone of curative treatment and a key predictor of survival. Current intraoperative …
View article: Label-free histological identification of intraductal carcinoma of the prostate using texture analysis-based multimodal stimulated Raman scattering microscopy
Label-free histological identification of intraductal carcinoma of the prostate using texture analysis-based multimodal stimulated Raman scattering microscopy Open
Intraductal carcinoma of the prostate (IDC-P) is a very aggressive histopathological subtype of prostate cancer (PCa) that is strongly associated with poor clinical outcomes but for which no accurate biomarkers exist. Here, we demonstrate …
View article: Experimental method to assess depth sensing limits of inelastic scattering measurements using spatial-offset Raman spectroscopy imaging
Experimental method to assess depth sensing limits of inelastic scattering measurements using spatial-offset Raman spectroscopy imaging Open
We showed the feasibility of using bilayer solid optical phantoms to create correlation curves between the optimal spatial offset for a desired probed depth given the optical properties of the top layer. The technique could facilitate the …
View article: Challenges and opportunities for new intraoperative optical techniques in the surgical treatment of pituitary adenomas: a review
Challenges and opportunities for new intraoperative optical techniques in the surgical treatment of pituitary adenomas: a review Open
Current imaging and navigation tools, although invaluable, have inherent limitations in resolution, integration, and molecular specificity. Raman spectroscopy offers a promising, label-free method for real-time tissue identification, espec…
View article: Development and preclinical evaluation of an endonasal Raman spectroscopy probe for transsphenoidal pituitary adenoma surgery
Development and preclinical evaluation of an endonasal Raman spectroscopy probe for transsphenoidal pituitary adenoma surgery Open
This work sets the stage for the clinical deployment of Raman spectroscopy as an intraoperative real-time decision support system during transsphenoidal surgery, with future work focused on clinical integration and the generalization of th…
View article: Preliminary study demonstrating cancer cells detection at the margins of whole glioblastoma specimens with Raman spectroscopy imaging
Preliminary study demonstrating cancer cells detection at the margins of whole glioblastoma specimens with Raman spectroscopy imaging Open
Intraoperative Raman spectroscopy uses near-infrared laser light to gain molecular information without causing damage. It can be used in vivo or ex vivo without exogenous contrast agents. Clinically, the technique was primarily used with m…
View article: Single-cell Raman spectroscopy detects pediatric focal cortical dysplasia
Single-cell Raman spectroscopy detects pediatric focal cortical dysplasia Open
Significance Focal cortical dysplasia (FCD) type II is the leading cause of drug-resistant focal epilepsy in children. While surgical resection offers the only definitive cure, its success is hindered by the challenge of precisely identify…
View article: Quantitative assessment of the generalizability of a brain tumor Raman spectroscopy machine learning model to various tumor types including astrocytoma and oligodendroglioma
Quantitative assessment of the generalizability of a brain tumor Raman spectroscopy machine learning model to various tumor types including astrocytoma and oligodendroglioma Open
Developing predictive models relying on the inelastic scattering contrast from a wider pool of Raman bands may improve detection accuracy for astrocytoma and oligodendroglioma. To do so, larger tumor datasets and a higher Raman photon sign…
View article: Texture-Analysis Classification of Intraductal Carcinoma of the Prostate Using Label-Free Multimodal Nonlinear Optical Imaging
Texture-Analysis Classification of Intraductal Carcinoma of the Prostate Using Label-Free Multimodal Nonlinear Optical Imaging Open
Intraductal carcinoma of the prostate (IDC-P) is a very aggressive histopathological subtype of prostate cancer (PCa) for which no accurate biomarkers exist. In our work, we apply a multimodal nonlinear optical imaging approach that uses s…
View article: Toward noncontact macroscopic imaging of multiple cancers using multi‐spectral inelastic scattering detection
Toward noncontact macroscopic imaging of multiple cancers using multi‐spectral inelastic scattering detection Open
Here we introduce a Raman spectroscopy approach combining multi‐spectral imaging and a new fluorescence background subtraction technique to image individual Raman peaks in less than 5 seconds over a square field‐of‐view of 1‐centimeter sid…
View article: Macroscopic inelastic scattering imaging using a hyperspectral line-scanning system identifies invasive breast cancer in lumpectomy and mastectomy specimens
Macroscopic inelastic scattering imaging using a hyperspectral line-scanning system identifies invasive breast cancer in lumpectomy and mastectomy specimens Open
We showed the potential of hyperspectral Raman imaging as an intraoperative breast cancer margin assessment technique that could help surgeons improve cosmesis and reduce the number of repeat procedures in breast cancer surgery.
View article: Liquid saliva-based Raman spectroscopy device with on-board machine learning detects COVID-19 infection in real-time
Liquid saliva-based Raman spectroscopy device with on-board machine learning detects COVID-19 infection in real-time Open
Raman spectroscopy and machine learning is used in combination to detect COVID-19 positive saliva in liquid form.
View article: Spectral effects and enhancement quantification in healthy human saliva with surface‐enhanced Raman spectroscopy using silver nanopillar substrates
Spectral effects and enhancement quantification in healthy human saliva with surface‐enhanced Raman spectroscopy using silver nanopillar substrates Open
Objectives Raman spectroscopy as a diagnostic tool for biofluid applications is limited by low inelastic scattering contributions compared to the fluorescence background from biomolecules. Surface‐enhanced Raman spectroscopy (SERS) can inc…
View article: Towards Non-contact Macroscopic Imaging of Multiple Cancers using Mulit-Spectral Inelastic Scattering Detection
Towards Non-contact Macroscopic Imaging of Multiple Cancers using Mulit-Spectral Inelastic Scattering Detection Open
In situ spontaneous Raman spectroscopy at sub-millimeter detection scales has been reported previously to guide tumor resection. However, single-point spectroscopy is limited in its ability to sample whole surgical margins rapidly and avoi…
View article: Subsecond lung cancer detection within a heterogeneous background of normal and benign tissue using single-point Raman spectroscopy
Subsecond lung cancer detection within a heterogeneous background of normal and benign tissue using single-point Raman spectroscopy Open
This proof of concept demonstrates fingerprint Raman spectroscopy is a promising tool for the detection of lung cancer during diagnostic procedures and can capture biomolecular changes associated with the presence of cancer among a complex…
View article: In Situ Brain Tumor Detection Using the Raman Spectroscopy Sentry System – Results of a Multicenter Study
In Situ Brain Tumor Detection Using the Raman Spectroscopy Sentry System – Results of a Multicenter Study Open
Safe and effective brain tumor surgery aims to remove tumor tissue, not non-tumoral brain. This is a challenge since tumor cells are often not visually distinguishable from peritumoral brain during surgery. To address this, we conducted a …
View article: Preclinical evaluation of Raman spectroscopy for pedicular screw insertion surgical guidance in a porcine spine model
Preclinical evaluation of Raman spectroscopy for pedicular screw insertion surgical guidance in a porcine spine model Open
We provide a foundation for RS in the orthopedic surgical guidance field. It shows that RS combined with machine learning is a rapid and accurate modality capable of discriminating tissues that are typically encountered in orthopedic proce…
View article: Spectral focusing-based stimulated Raman scattering microscopy using compact glass blocks for adjustable dispersion
Spectral focusing-based stimulated Raman scattering microscopy using compact glass blocks for adjustable dispersion Open
Spectral focusing is a well-established technique for increasing spectral resolution in coherent Raman scattering microscopy. However, current methods for tuning optical chirp in setups using spectral focusing, such as glass rods, gratings…
View article: Data from Highly Accurate Detection of Cancer <i>In Situ</i> with Intraoperative, Label-Free, Multimodal Optical Spectroscopy
Data from Highly Accurate Detection of Cancer <i>In Situ</i> with Intraoperative, Label-Free, Multimodal Optical Spectroscopy Open
Effectiveness of surgery as a cancer treatment is reduced when all cancer cells are not detected during surgery, leading to recurrences that negatively impact survival. To maximize cancer cell detection during cancer surgery, we designed a…
View article: Data from Highly Accurate Detection of Cancer <i>In Situ</i> with Intraoperative, Label-Free, Multimodal Optical Spectroscopy
Data from Highly Accurate Detection of Cancer <i>In Situ</i> with Intraoperative, Label-Free, Multimodal Optical Spectroscopy Open
Effectiveness of surgery as a cancer treatment is reduced when all cancer cells are not detected during surgery, leading to recurrences that negatively impact survival. To maximize cancer cell detection during cancer surgery, we designed a…
View article: Supplementary Material from Highly Accurate Detection of Cancer <i>In Situ</i> with Intraoperative, Label-Free, Multimodal Optical Spectroscopy
Supplementary Material from Highly Accurate Detection of Cancer <i>In Situ</i> with Intraoperative, Label-Free, Multimodal Optical Spectroscopy Open
Contains a table showing prominent Raman peaks for molecular species; Figures showing pathology images, Raman spectra, and boxplots of Fluorescence & Raman Peaks; Data processing methods for fluorescence and diffuse reflectance.
View article: Supplementary Material from Highly Accurate Detection of Cancer <i>In Situ</i> with Intraoperative, Label-Free, Multimodal Optical Spectroscopy
Supplementary Material from Highly Accurate Detection of Cancer <i>In Situ</i> with Intraoperative, Label-Free, Multimodal Optical Spectroscopy Open
Contains a table showing prominent Raman peaks for molecular species; Figures showing pathology images, Raman spectra, and boxplots of Fluorescence & Raman Peaks; Data processing methods for fluorescence and diffuse reflectance.
View article: In situ Raman spectroscopy and machine learning unveil biomolecular alterations in invasive breast cancer
In situ Raman spectroscopy and machine learning unveil biomolecular alterations in invasive breast cancer Open
Detection of cancer on the margins of surgically resected breast specimen is feasible with Raman spectroscopy.
View article: Open-sourced Raman spectroscopy data processing package implementing a baseline removal algorithm validated from multiple datasets acquired in human tissue and biofluids
Open-sourced Raman spectroscopy data processing package implementing a baseline removal algorithm validated from multiple datasets acquired in human tissue and biofluids Open
A new open-sourced spectroscopic data pre-processing package was validated on simulated and real-world in-human data and is now available to researchers and clinicians for the development of new clinical applications using Raman spectrosco…
View article: A clinical Raman spectroscopy imaging system and safety requirements for <i>in situ</i> intraoperative tissue characterization
A clinical Raman spectroscopy imaging system and safety requirements for <i>in situ</i> intraoperative tissue characterization Open
A clinical prototype Raman macroscopic imaging system for machine-learning-based molecular tissue margin characterization over a large field of view.
View article: Multispectral intraoperative imaging for the detection of the hemodynamic response to interictal epileptiform discharges
Multispectral intraoperative imaging for the detection of the hemodynamic response to interictal epileptiform discharges Open
Interictal epileptiform discharges (IEDs) are brief neuronal discharges occurring between seizures in patients with epilepsy. The characterization of the hemodynamic response function (HRF) specific to IEDs could increase the accuracy of o…
View article: Image-guided Raman spectroscopy navigation system to improve transperineal prostate cancer detection. Part 2: in-vivo tumor-targeting using a classification model combining spectral and MRI-radiomics features
Image-guided Raman spectroscopy navigation system to improve transperineal prostate cancer detection. Part 2: in-vivo tumor-targeting using a classification model combining spectral and MRI-radiomics features Open
In-situ Raman spectroscopy combined with mpMRI radiomics features can lead to highly accurate PCa detection for improved in-vivo targeting of biopsy sample collection and radiotherapy seed placement.