Frédéric Picou
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View article: A specific bone marrow cytokine pattern in de novo acute myeloid leukemia
A specific bone marrow cytokine pattern in de novo acute myeloid leukemia Open
Acute myeloid leukemia (AML) is a heterogeneous group of hematopoietic cancers. Cytokines play an important role in the regulation of normal and pathologic hematopoiesis. A pro-inflammatory state, described in hematopoietic malignancies, m…
View article: The Antioxidant TEMPOL Protects Human Hematopoietic Stem Cells From Culture-Mediated Loss of Functions
The Antioxidant TEMPOL Protects Human Hematopoietic Stem Cells From Culture-Mediated Loss of Functions Open
In a steady state, hematopoietic stem cells (HSC) exhibit very low levels of reactive oxygen species (ROS). Upon stress, HSC get activated and enter into proliferation and differentiation process to ensure blood cell regeneration. Once act…
View article: Low-Dose Pesticides Alter Primary Human Bone Marrow Mesenchymal Stem/Stromal Cells through ALDH2 Inhibition
Low-Dose Pesticides Alter Primary Human Bone Marrow Mesenchymal Stem/Stromal Cells through ALDH2 Inhibition Open
(1) Background: The impact of occupational exposure to high doses of pesticides on hematologic disorders is widely studied. Yet, lifelong exposure to low doses of pesticides, and more particularly their cocktail effect, although poorly kno…
View article: Occupational pesticide exposure increases risk of acute myeloid leukemia: a meta-analysis of case–control studies including 3,955 cases and 9,948 controls
Occupational pesticide exposure increases risk of acute myeloid leukemia: a meta-analysis of case–control studies including 3,955 cases and 9,948 controls Open
The impact of pesticides on health is a major public health concern. A higher risk to develop chronic lymphoid malignancies has been demonstrated to be associated with occupational pesticide exposure (OPE). By contrast, little is known of …
View article: Automated Early Detection of Myelodysplastic Syndrome within the General Population Using the Research Parameters of Beckman–Coulter DxH 800 Hematology Analyzer
Automated Early Detection of Myelodysplastic Syndrome within the General Population Using the Research Parameters of Beckman–Coulter DxH 800 Hematology Analyzer Open
The incidence of myelodysplastic syndrome increases with aging and the early diagnosis enables optimal care of these diseases. The DxH 800 hematology analyzer measures and calculates 126 cytological parameters, but only 23 are used for rou…
View article: Involvement of GPx-3 in the Reciprocal Control of Redox Metabolism in the Leukemic Niche
Involvement of GPx-3 in the Reciprocal Control of Redox Metabolism in the Leukemic Niche Open
The bone marrow (BM) microenvironment plays a crucial role in the development and progression of leukemia (AML). Intracellular reactive oxygen species (ROS) are involved in the regulation of the biology of leukemia-initiating cells, where …
View article: Horizontal meta-analysis identifies common deregulated genes across AML subgroups providing a robust prognostic signature
Horizontal meta-analysis identifies common deregulated genes across AML subgroups providing a robust prognostic signature Open
Advances in transcriptomics have improved our understanding of leukemic development and helped to enhance the stratification of patients. The tendency of transcriptomic studies to combine AML samples, regardless of cytogenetic abnormalitie…
View article: Reactive oxygen species levels differentiate <scp>CD34</scp><sup>+</sup> human progenitors based on <scp>CD38</scp> expression
Reactive oxygen species levels differentiate <span>CD34</span><sup>+</sup> human progenitors based on <span>CD38</span> expression Open
Low reactive oxygen species (ROS) levels are well‐established characteristics of mouse hematopoietic stem cells (HSCs). However, little is known about these levels in human HSCs. This study aimed at quantifying ROS levels in human CD34 + C…
View article: Bone marrow oxidative stress and specific antioxidant signatures in myelodysplastic syndromes
Bone marrow oxidative stress and specific antioxidant signatures in myelodysplastic syndromes Open
Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal stem cell disorders with an inherent tendency for transformation in secondary acute myeloid leukemia. This study focused on the redox metabolism of bone marrow (BM) cells …
View article: Correction: Disruption of gap junctions attenuates acute myeloid leukemia chemoresistance induced by bone marrow mesenchymal stromal cells
Correction: Disruption of gap junctions attenuates acute myeloid leukemia chemoresistance induced by bone marrow mesenchymal stromal cells Open
The original version of this Article omitted the following from the Acknowledgements: This research was also supported by grants to KZ (UL and L-CNRS). This has now been corrected in both the PDF and HTML versions of the Article.
View article: PB2074 AUTOMATED EARLY DETECTION OF MYELODYSPLASIA WITH BECKMAN‐COULTER DXH 800 HEMATOLOGY ANALYZER BY USING TEN RESEARCH PARAMETERS
PB2074 AUTOMATED EARLY DETECTION OF MYELODYSPLASIA WITH BECKMAN‐COULTER DXH 800 HEMATOLOGY ANALYZER BY USING TEN RESEARCH PARAMETERS Open
Background: Moderate anemia affects a substantial fraction of the elderly population and blood smear analysis can help to guide towards a diagnosis of myelodysplasia (MDS). Nevertheless, in medical laboratories, review of blood smear is re…
View article: PS989 ABNORMAL DNA METHYLATION MODIFIES HOX GENES EXPRESSION IN BONE MARROW MESENCHYMAL STROMAL CELLS OF MYELODYSPLASIAS AND DE NOVO ACUTE MYELOID LEUKEMIAS
PS989 ABNORMAL DNA METHYLATION MODIFIES HOX GENES EXPRESSION IN BONE MARROW MESENCHYMAL STROMAL CELLS OF MYELODYSPLASIAS AND DE NOVO ACUTE MYELOID LEUKEMIAS Open
Background: In the context of myelodysplasias (MDS) and acute mydeloid leukemias (AML), the discovery in hematopoietic cells of aberrant DNA methylation profiles and mutations in genes associated with DNA methylation regulation has allowed…
View article: PF200 CARBENOXOLONE REVERSES MICROENVIRONMENT‐INDUCED CHEMORESISTANCE OF ACUTE MYELOID LEUKEMIA
PF200 CARBENOXOLONE REVERSES MICROENVIRONMENT‐INDUCED CHEMORESISTANCE OF ACUTE MYELOID LEUKEMIA Open
Background: Bone marrow niche of acute myeloid leukemia (AML) regulates leukemic progression by favoring leukemic cell quiescence and chemoresistance. Niche components, especially mesenchymal stromal cells (MSCs) protect leukemic cells fro…