Frederic Risch
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View article: Escalation of Germinal Center Responses in Chronic <i>Litomosoides sigmodontis</i> Filarial Infection
Escalation of Germinal Center Responses in Chronic <i>Litomosoides sigmodontis</i> Filarial Infection Open
T follicular helper (T FH ) cells are the primary CD4 + T helper cell subset providing help to B cells for efficient antibody responses in vaccination, allergy, autoimmunity, and infectious diseases. Despite their critical involvement in i…
View article: Major basic protein and eosinophil peroxidase support microfilariae motility inhibition by eosinophil ETosis
Major basic protein and eosinophil peroxidase support microfilariae motility inhibition by eosinophil ETosis Open
Eosinophils are a hallmark of filarial infections. They are primary effector cells and can attack filariae by releasing extracellular traps that contain toxic cationic proteins, such as eosinophil peroxidase and major basic protein. Previo…
View article: Repeated sensitization of mice with microfilariae of Litomosoides sigmodontis induces pulmonary eosinophilia in an IL-33-dependent manner
Repeated sensitization of mice with microfilariae of Litomosoides sigmodontis induces pulmonary eosinophilia in an IL-33-dependent manner Open
Background Eosinophilia is a hallmark of helminth infections and eosinophils are essential in the protective immune responses against helminths. Nevertheless, the distinct role of eosinophils during parasitic filarial infection, allergy an…
View article: Eosinophils are an endogenous source of IL-4 during filarial infections and contribute to the development of an optimal T helper 2 response
Eosinophils are an endogenous source of IL-4 during filarial infections and contribute to the development of an optimal T helper 2 response Open
Interleukin-4 (IL-4) is a central regulator of type 2 immunity, crucial for the defense against multicellular parasites like helminths. This study focuses on its roles and cellular sources during Litomosoides sigmodontis infection, a model…
View article: Development of adult Dirofilaria immitis worms in the Rag2/Il-2rγ mouse model
Development of adult Dirofilaria immitis worms in the Rag2/Il-2rγ mouse model Open
Dirofilaria immitis is the causative agent for one of the major parasitic infections in dogs. It is currently not possible to reliably diagnose the infection before the development of fertile adult female worms and the presence of microfil…
View article: Eosinophils are an endogenous source of IL-4 during filarial infections and contribute to the development of an optimal T helper 2 response
Eosinophils are an endogenous source of IL-4 during filarial infections and contribute to the development of an optimal T helper 2 response Open
Interleukin-4 (IL-4) is a central regulator of type 2 immunity, crucial for the defense against multicellular parasites like helminths. This study focuses on its roles and cellular sources during Litomosoides sigmodontis infection, a model…
View article: The efficacy of the benzimidazoles oxfendazole and flubendazole against Litomosoides sigmodontis is dependent on the adaptive and innate immune system
The efficacy of the benzimidazoles oxfendazole and flubendazole against Litomosoides sigmodontis is dependent on the adaptive and innate immune system Open
Filarial nematodes can cause debilitating diseases such as lymphatic filariasis and onchocerciasis. Oxfendazole (OXF) is one promising macrofilaricidal candidate with improved oral availability compared to flubendazole (FBZ), and OXF is cu…
View article: Potential of Nucleic Acid Receptor Ligands to Improve Vaccination Efficacy against the Filarial Nematode Litomosoides sigmodontis
Potential of Nucleic Acid Receptor Ligands to Improve Vaccination Efficacy against the Filarial Nematode Litomosoides sigmodontis Open
More than two-hundred-million people are infected with filariae worldwide. However, there is no vaccine available that confers long-lasting protection against filarial infections. Previous studies indicated that vaccination with irradiated…
View article: Comparison of the macrofilaricidal efficacy of oxfendazole and its isomers against the rodent filaria Litomosoides sigmodontis
Comparison of the macrofilaricidal efficacy of oxfendazole and its isomers against the rodent filaria Litomosoides sigmodontis Open
Oxfendazole is one of the lead macrofilaricidal candidates for the treatment of onchocerciasis and lymphatic filariasis. Originally, oxfendazole was developed for the veterinary market, where it is mainly used to treat intestinal helminth …
View article: Nucleic acid receptor ligands improve vaccination efficacy against the filarial nematode<i>Litomosoides sigmodontis</i>
Nucleic acid receptor ligands improve vaccination efficacy against the filarial nematode<i>Litomosoides sigmodontis</i> Open
Infections with helminths affect more than one billion people worldwide. Despite an urgent need there is no vaccine available that would confer long lasting protection against helminth infections. Previous studies indicated that a vaccinat…
View article: ILC2s Control Microfilaremia During Litomosoides sigmodontis Infection in Rag2-/- Mice
ILC2s Control Microfilaremia During Litomosoides sigmodontis Infection in Rag2-/- Mice Open
Group 2 innate lymphoid cells (ILC2s) are inducers of type 2 immune responses, but their role during filarial infection remains unclear. In the present study, we used the Litomosoides sigmodontis rodent model of filariasis to analyze ILC2s…
View article: Protection of <i>Batf3</i>‐deficient mice from experimental cerebral malaria correlates with impaired cytotoxic T‐cell responses and immune regulation
Protection of <i>Batf3</i>‐deficient mice from experimental cerebral malaria correlates with impaired cytotoxic T‐cell responses and immune regulation Open
Summary Excessive inflammatory immune responses during infections with Plasmodium parasites are responsible for severe complications such as cerebral malaria (CM) that can be studied experimentally in mice. Dendritic cells (DCs) activate c…