Frédéric S. Michel
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View article: Chronic Phase Shifts Are Associated With Higher Systolic Blood Pressure and Impaired Glucose Tolerance Independently of Estrogen Deficiency in Female Spontaneously Hypertensive Rats
Chronic Phase Shifts Are Associated With Higher Systolic Blood Pressure and Impaired Glucose Tolerance Independently of Estrogen Deficiency in Female Spontaneously Hypertensive Rats Open
Postmenopausal shift workers face increased cardiometabolic risk due to estrogen decline and shift work–induced circadian misalignment. Yet, their combined effects remain poorly understood, especially in hypertensive individuals. This stud…
View article: Involvement of microRNA-146a-5p, but not -155-5p and -29b-5p, in left ventricular remodeling and dysfunction in spontaneously hypertensive rats
Involvement of microRNA-146a-5p, but not -155-5p and -29b-5p, in left ventricular remodeling and dysfunction in spontaneously hypertensive rats Open
We investigated roles of microRNAs-146a-5p, -155-5p, and -29b-5p in development of cardiac hypertrophy and dysfunction in SHRs. We showed that miR-146a-5p expression was upregulated in SHRs and positively associated with indices of concent…
View article: Decreased blood pressure with acute administration of quercetin in L‐NAME‐induced hypertensive rats
Decreased blood pressure with acute administration of quercetin in L‐NAME‐induced hypertensive rats Open
Quercetin is known to reduce blood pressure (BP); however, its acute effects are unclear. We investigated the acute effects of quercetin on BP, aortic mechanical properties and vascular reactivity in female Sprague–Dawley (SD) rats. Hypert…
View article: Involvement of pentraxin‐3 in the development of hypertension but not left ventricular hypertrophy in male spontaneously hypertensive rats
Involvement of pentraxin‐3 in the development of hypertension but not left ventricular hypertrophy in male spontaneously hypertensive rats Open
Hypertension drives the development of concentric left ventricular hypertrophy (LVH). However, the relative contribution of pentraxin‐3 (PTX‐3), a novel marker for inflammatory cardiovascular disease, in the hypertrophic response to pressu…
View article: SA Heart consensus statement on closure of patent foramen ovale 2021
SA Heart consensus statement on closure of patent foramen ovale 2021 Open
A patent foramen ovale (PFO) is associated with numerous clinical conditions. The most severe of these is cryptogenic stroke. This consensus statement aims to provide a clinical guideline on which patients should be offered PFO closure.
View article: The effect of TNF-α inhibitor treatment on microRNAs and endothelial function in collagen induced arthritis
The effect of TNF-α inhibitor treatment on microRNAs and endothelial function in collagen induced arthritis Open
Chronic inflammation causes dysregulated expression of microRNAs. Aberrant microRNA expression is associated with endothelial dysfunction. In this study we determined whether TNF-α inhibition impacted the expression of miRNA-146a-5p and mi…
View article: Associations of inflammatory markers with impaired left ventricular diastolic and systolic function in collagen-induced arthritis
Associations of inflammatory markers with impaired left ventricular diastolic and systolic function in collagen-induced arthritis Open
High-grade inflammation is associated with impaired LV diastolic function and greater myocardial deformation independent of haemodynamic load in CIA rats.
View article: Supplemental Table 2
Supplemental Table 2 Open
Short- axis systolic segmental velocity and displacement in the CIA and control groups
View article: Supplemental Tables 1 and 2
Supplemental Tables 1 and 2 Open
Supplemental data: Inflammation induced changes in left ventricular diastolic and systolic function in collagen-induced arthritis
View article: Supplemental Table 1
Supplemental Table 1 Open
Short- axis systolic segmental strain and strain rate in the CIA and control groups.
View article: Supplemental Table 1
Supplemental Table 1 Open
Supplemental data: Inflammation induced changes in left ventricular diastolic and systolic function in collagen-induced arthritis
View article: Systemic Angiotensinogen Concentrations Are Independently Associated With Left Ventricular Diastolic Function in a Community Sample
Systemic Angiotensinogen Concentrations Are Independently Associated With Left Ventricular Diastolic Function in a Community Sample Open
BACKGROUND Left ventricular (LV) diastolic dysfunction characterizes heart failure with a preserved ejection fraction. Although it is recognized that the renin–angiotensin–aldosterone system (RAAS) decreases LV diastolic function, whether …