Explanipedia

Early alterations of motor learning and corticostriatal network activity in a Huntington’s disease mouse model Open

Nagham Badreddine, Florence Appaix, Guillaume Becq, Sophie Achard, Frédéric Saudou , et al. · 2024

Huntington’s disease (HD) is a neurodegenerative disorder that presents motor, cognitive and psychiatric symptoms as it progresses. Prior to motor symptoms onset, alterations and dysfunctions in the corticostriatal projections have been de…

Mono- and Biallelic Inactivation of Huntingtin Gene in Patient-Specific Induced Pluripotent Stem Cells Reveal HTT Roles in Striatal Development and Neuronal Functions Open

Morgane Louessard, Michel Cailleret, Margot Jarrige, Julie Bigarreau, Sophie Lenoir , et al. · 2024

Background: Mutations in the Huntingtin (HTT) gene cause Huntington’s disease (HD), a neurodegenerative disorder. As a scaffold protein, HTT is involved in numerous cellular functions, but its normal and pathogenic functions during human f…

Stretch-injury promotes microglia activation with enhanced phagocytic and synaptic stripping activities Open

Anthony Procès, Yeranddy A. Alpízar, Sophie Halliez, Bert Brône, Frédéric Saudou , et al. · 2023

Microglial cells, as the primary defense line in the central nervous system, play a crucial role in responding to various mechanical signals that can trigger their activation. Despite extensive research on the impact of chemical signaling …

Customization of the translational complex regulates mRNA-specific translation to control CNS regeneration Open

Julia Schaeffer, Noémie Vilallongue, Charlotte Decourt, Béatrice Blot, Nacéra El Bakdouri , et al. · 2023

Author response: Huntingtin recruits KIF1A to transport synaptic vesicle precursors along the mouse axon to support synaptic transmission and motor skill learning Open

Hélène Vitet, Julie Bruyère, Hao Xu, Claire Séris, Jacques Brocard , et al. · 2023

Full text Figures and data Side by side Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Neurotr…

Stretch-injury promotes activation of microglia with enhanced phagocytic and synaptic stripping activities Open

Anthony Procès, Yeranddy A. Alpízar, Sophie Halliez, Bert Brône, Frédéric Saudou , et al. · 2023

Microglial cells must act as the first line of defense of the central nervous system, but they can be exposed to various mechanical signals that may trigger their activation. While the impact of chemical signaling on brain cells has been s…

Huntingtin regulates calcium fluxes in skeletal muscle Open

Mathilde Chivet, Maximilian McCluskey, Anne‐Sophie Nicot, Julie Brocard, Mathilde Beaufils , et al. · 2022

The expression of the Huntingtin protein, well known for its involvement in the neurodegenerative Huntington’s disease, has been confirmed in skeletal muscle. The impact of HTT deficiency was studied in human skeletal muscle cell lines and…

Pridopidine rescues BDNF/TrkB trafficking dynamics and synapse homeostasis in a Huntington disease brain-on-a-chip model Open

Sophie Lenoir, Romane A. Lahaye, Hélène Vitet, Chiara Scaramuzzino, Amandine Virlogeux , et al. · 2022

Huntington disease (HD) is a neurodegenerative disorder caused by polyglutamine-encoding CAG repeat expansion in the huntingtin (HTT) gene. HTT is involved in the axonal transport of vesicles containing brain-derived neurotrophic factor (B…

Controlled Tau Cleavage in Cells Reveals Abnormal Localizations of Tau Fragments Open

Anne Fourest‐Lieuvin, Angélique Vinit, Béatrice Blot, Anthime Perrot, Éric Denarier , et al. · 2022

Huntingtin-KIF1A-mediated axonal transport of synaptic vesicle precursors influences synaptic transmission and motor skill learning in mice Open

Hélène Vitet, Julie Bruyère, Hao Xu, Jacques Brocard, Yah Sé Abada , et al. · 2022

Neurotransmitters are released at synapses by synaptic vesicles (SVs), which originate from SV precursors (SVPs) that have traveled along the axon. Because each synapse maintains a pool of SVs, only a small fraction of which are released, …

A pathogenic proteolysis–resistant huntingtin isoform induced by an antisense oligonucleotide maintains huntingtin function Open

Hyeongju Kim, Sophie Lenoir, Angela Helfricht, Tae‐Yang Jung, Zhana K. Karneva , et al. · 2022

Huntington's disease (HD) is a late-onset neurological disorder for which therapeutics are not available. Its key pathological mechanism involves the proteolysis of polyglutamine-expanded (polyQ-expanded) mutant huntingtin (mHTT), which ge…

Spatiotemporal reorganization of corticostriatal networks encodes motor skill learning Open

Nagham Badreddine, Gisela Zalcman, Florence Appaix, Guillaume Becq, Nicolas Tremblay , et al. · 2022

Calcineurin and huntingtin form a calcium-sensing machinery that directs neurotrophic signals to the nucleus Open

Chiara Scaramuzzino, Emeline C. Cuoc, Patrick Pla, Sandrine Humbert, Frédéric Saudou · 2022

Neurotrophin-bearing endosomes respond to local calcium concentrations to self-direct long-range retrograde transport.

Publisher Correction: ATP-citrate lyase promotes axonal transport across species Open

Aviel Even, Giovanni Morelli, Silvia Turchetto, Michal Shilian, Romain Le Bail , et al. · 2021

Huntingtin-mediated axonal transport requires arginine methylation by PRMT6 Open

Alice Migazzi, Chiara Scaramuzzino, Eric N. Anderson, Debasmita Tripathy, Ivó H. Hernández , et al. · 2021

Recreating mouse cortico-hippocampal neuronal circuit in microfluidic devices to study BDNF axonal transport upon glucocorticoid treatment Open

Sophie Lenoir, Aurélie Genoux, Fabienne Agasse, Frédéric Saudou, Sandrine Humbert · 2021

Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing Open

Stephen C. Cunnane, Eugenia Trushina, Cecilie Morland, Alessandro Prigione, Gemma Casadesús , et al. · 2020

ATP-Citrate lyase fuels axonal transport across species Open

Aviel Even, Giovanni Morelli, Romain Le Bail, Michal Shilian, Silvia Turchetto , et al. · 2020

Microtubule (MT)-based transport is an evolutionary conserved processed finely tuned by posttranslational modifications. Among them, α-tubulin acetylation, which is catalyzed by the α-tubulin N-acetyltransferase 1, Atat1, promotes the recr…

The Arp1/11 Minifilament of Dynactin Primes the Endosomal Arp2/3 Complex Open

Artem I. Fokin, Violaine David, Ksénia Oguievetskaia, Emmanuel Derivery, Caroline Stone , et al. · 2020

Dendritic actin networks develop from a first actin filament through branching by the Arp2/3 complex. At the surface of endosomes, the WASH complex activates the Arp2/3 complex and interacts with the Capping Protein for unclear reasons. He…

Author response: Presynaptic APP levels and synaptic homeostasis are regulated by Akt phosphorylation of huntingtin Open

Julie Bruyère, Yah-se K. Abada, Hélène Vitet, Gaëlle Fontaine, Jean‐Christophe Deloulme , et al. · 2020

Article Figures and data Abstract Introduction Results Discussion Materials and methods Appendix 1 Data availability References Decision letter Author response Article and author information Metrics Abstract Studies have suggested that amy…

Presynaptic APP levels and synaptic homeostasis are regulated by Akt phosphorylation of Huntingtin Open

Julie Bruyère, Yah-se K. Abada, Hélène Vitet, Gaëlle Fontaine, Jean‐Christophe Deloulme , et al. · 2020

Studies have suggested that amyloid precursor protein (APP) regulates synaptic homeostasis, but the evidence has not been consistent. In particular, signaling pathways controlling APP transport to the synapse in axons and dendrites remain …

Huntingtin-Mediated Axonal Transport Requires Arginine Methylation by PRMT6 Open

Alice Migazzi, Chiara Scaramuzzino, Eric N. Anderson, Debasmita Tripathy, Ivó H. Hernández , et al. · 2020

Huntingtin phosphorylation governs BDNF homeostasis and improves the phenotype of Mecp2 knockout mice Open

Yann Ehinger, Julie Bruyère, Nicolas Panayotis, Yah-se K. Abada, Emilie Borloz , et al. · 2019

Mutations in the X-linked MECP2 gene are responsible for Rett syndrome (RTT), a severe neurological disorder for which there is no treatment. Several studies have linked the loss of MeCP2 function to alterations of brain-derived neurotroph…

ATAT1-enriched vesicles promote microtubule acetylation via axonal transport Open

Aviel Even, Giovanni Morelli, Chiara Scaramuzzino, Ivan Gladwyn‐Ng, Romain Le Bail , et al. · 2019

Microtubules are polymerized dimers of α- and β-tubulin that underlie a broad range of cellular activities. Acetylation of α-tubulin by the acetyl-transferase ATAT1 modulates microtubule dynamics and functions in neurons. However, it remai…

The cortico-striatal circuit regulates sensorimotor gating via Disc1/Huntingtin-mediated Bdnf transport Open

Hanna Jaaro-Peled, Sunil Kumar, Dalton Hughes, Sun-Hong Kim, Sandra Zoubovsky , et al. · 2018

Sensorimotor information processing that underlies normal cognitive and behavioral traits is dysregulated across a subset of neurological and psychiatric disorders. The cross-disease deficit in sensorimotor gating poses a unique opportunit…

Neuronal network maturation differently affects secretory vesicles and mitochondria transport in axons Open

Eve Moutaux, Wilhelm Christaller, Chiara Scaramuzzino, Aurélie Genoux, Benoît Charlot , et al. · 2018

Region-specific and state-dependent action of striatal GABAergic interneurons Open

Élodie Fino, Marie Vandecasteele, Sylvie Pérez, Frédéric Saudou, Laurent Venance · 2018

Striatum processes a wide range of functions including goal-directed behavior and habit formation, respectively encoded by the dorsomedial striatum (DMS) and dorsolateral striatum (DLS). GABAergic feedforward inhibition is known to control…

Pharmacological modulation of AMPA receptor surface diffusion restores hippocampal synaptic plasticity and memory in Huntington’s disease Open

Hongyu Zhang, Chun-Lei Zhang, Jean Vincent, Diana Zala, Caroline Benstaali , et al. · 2018

Impaired hippocampal synaptic plasticity is increasingly considered to play an important role in cognitive impairment in Huntington’s disease (HD). However, the molecular basis of synaptic plasticity defects is not fully understood. Combin…

Vesicular elongator regulates axonal transport via a-tubulin acetylation Open

Aviel Even, Giovanni Morelli, Brunella Franco, Michal Shilian, Vered Holdengreber , et al. · 2018

[Even, A.; Shilian, M.] Tel Aviv Univ, George S Wise Fac Life Sci, Lab Neurodegenerat Dis & Personalized Med, Sagol Sch Neurosci,Dept Cell Res & Immuno, IL-69978 Tel Aviv, Israel. [Morelli, G.; Franco, B.; Malgrange, B.; Nguyen, L.] GIG A …

The striatal kinase DCLK3 produces neuroprotection against mutant huntingtin Open

Laurie Galvan, Laetitia Francelle, Marie‐Claude Gaillard, Lucie de Longprez, María-Angeles Carrillo-de Sauvage , et al. · 2018

The neurobiological functions of a number of kinases expressed in the brain are unknown. Here, we report new findings on DCLK3 (doublecortin like kinase 3), which is preferentially expressed in neurons in the striatum and dentate gyrus. It…

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