Frederic Shapiro
YOU?
Author Swipe
View article: Pudgy mouse rib deformities emanate from abnormal paravertebral longitudinal cartilage/bone accumulations
Pudgy mouse rib deformities emanate from abnormal paravertebral longitudinal cartilage/bone accumulations Open
The pudgy (pu/pu) mouse, caused by a recessive mutation in the Notch family Delta like-3 gene (Dll3), has severe rib, vertebral body and intervertebral disc abnormalities. Using whole-mount preparations and serial histologic sections we de…
View article: LAMELLAR THICKNESS MEASUREMENTS IN NORMAL AND OSTEOGENESIS IMPERFECTA HUMAN BONE, with development of a method of automated thickness averaging to simplify quantitation
LAMELLAR THICKNESS MEASUREMENTS IN NORMAL AND OSTEOGENESIS IMPERFECTA HUMAN BONE, with development of a method of automated thickness averaging to simplify quantitation Open
Purpose Lamellar bone that forms in moderate and severe osteogenesis imperfecta (OI) is often composed of structurally irregular lamellae compared to those in normal bone. Polarization light microscopy (PLM) demonstrates lamellar bone well…
View article: Direct Reprogramming of Mouse Fibroblasts into Functional Osteoblasts
Direct Reprogramming of Mouse Fibroblasts into Functional Osteoblasts Open
Although induced pluripotent stem cells hold promise as a potential source of osteoblasts for skeletal regeneration, the induction of pluripotency followed by directed differentiation into osteoblasts is time consuming and low yield. In co…
View article: Woven bone overview: structural classification based on its integral role in developmental, repair and pathological bone formation throughout vertebrate groups
Woven bone overview: structural classification based on its integral role in developmental, repair and pathological bone formation throughout vertebrate groups Open
Cortical bone development is characterised by initial formation of woven bone followed by deposition of lamellar bone on the woven scaffold. This occurs in normal bone formation as an integral obligate self-assembly pattern throughout all …