Frederick A. Partridge
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View article: Essential role of proline synthesis and the one-carbon metabolism pathways for systemic virulence of <i>Streptococcus pneumoniae</i>
Essential role of proline synthesis and the one-carbon metabolism pathways for systemic virulence of <i>Streptococcus pneumoniae</i> Open
Virulence screens have indicated potential roles during Streptococcus pneumoniae infection for the one-carbon metabolism pathway component Fhs and proline synthesis mediated by ProABC. To define how these metabolic pathways affect S. pneum…
View article: A drug repurposing screen for whipworms informed by comparative genomics
A drug repurposing screen for whipworms informed by comparative genomics Open
Hundreds of millions of people worldwide are infected with the whipworm Trichuris trichiura . Novel treatments are urgently needed as current drugs, such as albendazole, have relatively low efficacy. We have investigated whether drugs appr…
View article: Essential role of proline synthesis and the one-carbon metabolism pathways for systemic virulence of<i>Streptococcus pneumoniae</i>
Essential role of proline synthesis and the one-carbon metabolism pathways for systemic virulence of<i>Streptococcus pneumoniae</i> Open
Previous virulence screens have indicated potential roles during Streptococcus pneumoniae infection for the one-carbon metabolism pathway component Fhs and proline synthesis mediated by ProABC. To define how these metabolic pathways affect…
View article: A drug repurposing screen for whipworms informed by comparative genomics
A drug repurposing screen for whipworms informed by comparative genomics Open
Hundreds of millions of people worldwide are infected with the whipworm Trichuris trichiura . Novel treatments are urgently needed as current drugs, such as albendazole, have relatively low efficacy. We have investigated whether drugs appr…
View article: Screening the Medicines for Malaria Venture (MMV) Pandemic Response Box chemical library on Caenorhabditis elegans identifies re-profiled candidate anthelmintic drug leads
Screening the Medicines for Malaria Venture (MMV) Pandemic Response Box chemical library on Caenorhabditis elegans identifies re-profiled candidate anthelmintic drug leads Open
The 3 major classes of soil transmitted helminths (whipworm, hookworm and Ascaris) affect 1.5 billion people worldwide mostly in poor countries, where they have adverse effects on child development, nutrition, and the work capacity of adul…
View article: Screening the Medicines for Malaria Pandemic Response Box chemical library on<i>Caenorhabditis elegans</i>identifies re-profiled candidate anthelmintic drug leads
Screening the Medicines for Malaria Pandemic Response Box chemical library on<i>Caenorhabditis elegans</i>identifies re-profiled candidate anthelmintic drug leads Open
The 3 major classes of soil transmitted helminths (whipworm, hookworm and Ascaris) affect 1.5 billion people worldwide mostly in poor countries, where they have adverse effects on child development, nutrition, and the work capacity of adul…
View article: Un-‘Egg’-Plored: Characterisation of Embryonation in the Whipworm Model Organism Trichuris muris
Un-‘Egg’-Plored: Characterisation of Embryonation in the Whipworm Model Organism Trichuris muris Open
Trichuris muris , is the murine parasite and widely deployed model for the human whipworm Trichuris trichiura , a parasite that infects around 500 million people globally. Trichuriasis is a classical disease of poverty with a cycle of re-i…
View article: Actions of Camptothecin Derivatives on Larvae and Adults of the Arboviral Vector Aedes aegypti
Actions of Camptothecin Derivatives on Larvae and Adults of the Arboviral Vector Aedes aegypti Open
Mosquito-borne viruses including dengue, Zika, and Chikungunya viruses, and parasites such as malaria and Onchocerca volvulus endanger health and economic security around the globe, and emerging mosquito-borne pathogens have pandemic poten…
View article: Actions of camptothecin derivatives on larvae and adults of the arboviral vector<i>Aedes aegypti</i>
Actions of camptothecin derivatives on larvae and adults of the arboviral vector<i>Aedes aegypti</i> Open
Mosquito-borne viruses including dengue, Zika and Chikungunya viruses as well as parasites such as malaria and Onchocerca volvulus endanger health and economic security around the globe and emerging mosquito-borne pathogens have pandemic p…
View article: Automated phenotyping of mosquito larvae enables high-throughput screening for novel larvicides and offers potential for smartphone-based detection of larval insecticide resistance
Automated phenotyping of mosquito larvae enables high-throughput screening for novel larvicides and offers potential for smartphone-based detection of larval insecticide resistance Open
Pyrethroid-impregnated nets have contributed significantly to halving the burden of malaria but resistance threatens their future efficacy and the pipeline of new insecticides is short. Here we report that an invertebrate automated phenoty…
View article: Structural Requirements for Dihydrobenzoxazepinone Anthelmintics: Actions against Medically Important and Model Parasites: <i>Trichuris muris</i> , <i>Brugia malayi</i> , <i>Heligmosomoides polygyrus</i> , and <i>Schistosoma mansoni</i>
Structural Requirements for Dihydrobenzoxazepinone Anthelmintics: Actions against Medically Important and Model Parasites: <i>Trichuris muris</i> , <i>Brugia malayi</i> , <i>Heligmosomoides polygyrus</i> , and <i>Schistosoma mansoni</i> Open
Nine hundred million people are infected with the soil-transmitted helminths Ascaris lumbricoides (roundworm), hookworm, and Trichuris trichiura (whipworm). However, low single-dose cure rates of the benzimidazole drugs, the …
View article: Structural requirements for dihydrobenzoxazepinone anthelmintics: actions against medically important and model parasites -<i>Trichuris muris</i>,<i>Brugia malayi</i>,<i>Heligmosomoides polygyrus</i>and<i>Schistosoma mansoni</i>
Structural requirements for dihydrobenzoxazepinone anthelmintics: actions against medically important and model parasites -<i>Trichuris muris</i>,<i>Brugia malayi</i>,<i>Heligmosomoides polygyrus</i>and<i>Schistosoma mansoni</i> Open
Nine hundred million people are infected with the soil-transmitted helminths Ascaris lumbricoides (roundworm), hookworm, and Trichuris trichiura (whipworm). However, low single-dose cure rates of the benzimidazole drugs, the mainstay of pr…
View article: Automated phenotyping of mosquito larvae enables high-throughput screening for novel larvicides and offers potential for smartphone-based detection of larval insecticide resistance
Automated phenotyping of mosquito larvae enables high-throughput screening for novel larvicides and offers potential for smartphone-based detection of larval insecticide resistance Open
Pyrethroid-impregnated nets have contributed significantly to halving the burden of malaria but resistance threatens their future efficacy and the pipeline of new insecticides is short. Here we report that an invertebrate automated phenoty…
View article: Anthelmintic drug discovery: target identification, screening methods and the role of open science
Anthelmintic drug discovery: target identification, screening methods and the role of open science Open
Helminths, including cestodes, nematodes and trematodes, are a huge global health burden, infecting hundreds of millions of people. In many cases, existing drugs such as benzimidazoles, diethylcarbamazine, ivermectin and praziquantel are i…
View article: C. elegans expressing D76N β2-microglobulin: a model for in vivo screening of drug candidates targeting amyloidosis
C. elegans expressing D76N β2-microglobulin: a model for in vivo screening of drug candidates targeting amyloidosis Open
View article: Improved reference genome of Aedes aegypti informs arbovirus vector control
Improved reference genome of Aedes aegypti informs arbovirus vector control Open
View article: 2,4-Diaminothieno[3,2-d]pyrimidines, a new class of anthelmintic with activity against adult and egg stages of whipworm
2,4-Diaminothieno[3,2-d]pyrimidines, a new class of anthelmintic with activity against adult and egg stages of whipworm Open
The human whipworm Trichuris trichiura is a parasite that infects around 500 million people globally, with consequences including damage to physical growth and educational performance. Current drugs such as mebendazole have a notable lack …
View article: The fungal alkaloid Okaramine-B activates an L-glutamate-gated chloride channel from Ixodes scapularis, a tick vector of Lyme disease
The fungal alkaloid Okaramine-B activates an L-glutamate-gated chloride channel from Ixodes scapularis, a tick vector of Lyme disease Open
View article: 2,4-Diaminothieno[3,2-<i>d</i>]pyrimidines, a new class of anthelmintic with activity against adult and egg stages of whipworm
2,4-Diaminothieno[3,2-<i>d</i>]pyrimidines, a new class of anthelmintic with activity against adult and egg stages of whipworm Open
The human whipworm Trichuris trichiura is a parasite that infects around 500 million people globally, with consequences including damage to physical growth and educational performance. Current drugs such as mebendazole have a notable lack …
View article: Improved<i>Aedes aegypti</i>mosquito reference genome assembly enables biological discovery and vector control
Improved<i>Aedes aegypti</i>mosquito reference genome assembly enables biological discovery and vector control Open
Female Aedes aegypti mosquitoes infect hundreds of millions of people each year with dangerous viral pathogens including dengue, yellow fever, Zika, and chikungunya. Progress in understanding the biology of this insect, and developing tool…
View article: An automated high-throughput system for phenotypic screening of chemical libraries on C. elegans and parasitic nematodes
An automated high-throughput system for phenotypic screening of chemical libraries on C. elegans and parasitic nematodes Open
View article: An automated high-throughput system for phenotypic screening of chemical libraries on<i>C. elegans</i>and parasitic nematodes
An automated high-throughput system for phenotypic screening of chemical libraries on<i>C. elegans</i>and parasitic nematodes Open
Parasitic nematodes infect hundreds of millions of people and farmed livestock. Further, plant parasitic nematodes result in major crop damage. The pipeline of therapeutic compounds is limited and parasite resistance to the existing anthel…
View article: Dihydrobenz[e][1,4]oxazepin-2(3H)-ones, a new anthelmintic chemotype immobilising whipworm and reducing infectivity in vivo
Dihydrobenz[e][1,4]oxazepin-2(3H)-ones, a new anthelmintic chemotype immobilising whipworm and reducing infectivity in vivo Open
Trichuris trichiura is a human parasitic whipworm infecting around 500 million people globally, damaging the physical growth and educational performance of those infected. Current drug treatment options are limited and lack efficacy agains…