Frederick J. Meyers
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View article: Academic research careers for medical doctors (ARC-MD): a five-year UC Davis training program to foster the next generation of physician-scientists
Academic research careers for medical doctors (ARC-MD): a five-year UC Davis training program to foster the next generation of physician-scientists Open
Since the establishment of the Flexnerian model of medical education, single degree (MD) physician-scientists have significantly advanced biomedical research and clinical medicine. However, institutional emphasis has predominantly favoured…
View article: Metabolomic assessment of low versus high volume resuscitation in a combined porcine model of severe burn and traumatic brain injury
Metabolomic assessment of low versus high volume resuscitation in a combined porcine model of severe burn and traumatic brain injury Open
Background: Severe burns continue to be associated with significant morbidity and mortality despite advances in resuscitation techniques. Concomitant injury such as traumatic brain injury adds complexity to resuscitation paradigms as high …
View article: Asking Different Questions: Development and implementation of Clinical and Translational Science Award diversity, equity, and inclusion and community engagement training course for TL1 scholars
Asking Different Questions: Development and implementation of Clinical and Translational Science Award diversity, equity, and inclusion and community engagement training course for TL1 scholars Open
Introduction: In recent years, there has been a growth in awareness of the importance of equity and community engagement in clinical and translational research. One key limitation of most training programs is that they focus on change at t…
View article: Canine glioma stem-like cells demonstrate DNA methylation-dependent enhancement of cellular respiration following low oxygen tension
Canine glioma stem-like cells demonstrate DNA methylation-dependent enhancement of cellular respiration following low oxygen tension Open
Glioma stem cells (GSCs) have been implicated in radio- and chemotherapeutic resistance of glioblastoma (GBM). Therapeutic targeting of GSCs has shown promise in immunocompromised rodent models but have not been translated into effective t…
View article: A Machine Learning Model to Predict Risk for Hepatocellular Carcinoma in Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease
A Machine Learning Model to Predict Risk for Hepatocellular Carcinoma in Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease Open
View article: Intra- and Intertumoral Microglia/Macrophage Infiltration and Their Associated Molecular Signature Is Highly Variable in Canine Oligodendroglioma: A Preliminary Evaluation
Intra- and Intertumoral Microglia/Macrophage Infiltration and Their Associated Molecular Signature Is Highly Variable in Canine Oligodendroglioma: A Preliminary Evaluation Open
The goal of this study was to define the glioma-associated microglia/macrophage (GAM) response and associated molecular landscape in canine oligodendrogliomas. Here, we quantified the intratumoral GAM density of low- and high-grade oligode…
View article: Lipoprotein(a) and diet—a challenge for a role of saturated fat in cardiovascular disease risk reduction?
Lipoprotein(a) and diet—a challenge for a role of saturated fat in cardiovascular disease risk reduction? Open
In this perspective, we discuss new evidence relating to current dietary recommendations to reduce SFA intake to modulate an individual's global risk of CVD. Although it is well established that lowering dietary SFA intake has a beneficial…
View article: Robot-Mediated Social Connectedness Maintains Friendships and Improves School Reintegration for Childhood Cancer Survivors
Robot-Mediated Social Connectedness Maintains Friendships and Improves School Reintegration for Childhood Cancer Survivors Open
Background: Each year in the U.S. there are an estimated 15,780 children between the ages of birth and 19 years of age who are diagnosed with cancer. Many are also medically restricted to their homes each year due to sympt…
View article: Accessing and utilizing clinical and genomic data from an electronic health record data warehouse
Accessing and utilizing clinical and genomic data from an electronic health record data warehouse Open
Electronic health records (EHRs) and linked biobanks have tremendous potential to advance biomedical research and ultimately improve the health of future generations. Repurposing EHR data for research is not without challenges, however. In…
View article: Microglia-Derived Olfactomedin-like 3 Is a Potent Angiogenic Factor in Primary Mouse Brain Endothelial Cells: A Novel Target for Glioblastoma
Microglia-Derived Olfactomedin-like 3 Is a Potent Angiogenic Factor in Primary Mouse Brain Endothelial Cells: A Novel Target for Glioblastoma Open
Neoangiogenesis, a hallmark feature of all malignancies, is robust in glioblastoma (GBM). Vascular endothelial growth factor (VEGF) has long been regarded as the primary pro-angiogenic molecule in GBM. However, anti-VEGF therapies have had…
View article: Prevalence and Clinicopathologic Features of Canine Metastatic Melanoma Involving the Central Nervous System: A Retrospective Analysis and Comparative Review
Prevalence and Clinicopathologic Features of Canine Metastatic Melanoma Involving the Central Nervous System: A Retrospective Analysis and Comparative Review Open
Background Central nervous system (CNS) involvement is the leading cause of death in malignant melanoma. Rodent models, while vital to mechanistic investigation, have had limited success identifying effective therapies for melanoma brain m…
View article: The transition from in-person to virtual museum programing for individuals living with chronic pain – A formative evaluation
The transition from in-person to virtual museum programing for individuals living with chronic pain – A formative evaluation Open
Museum engagement may be an effective approach for decreasing social disconnection and pain among individuals living with chronic pain. In October 2019, we launched a randomized controlled trial to assess the feasibility of museum engageme…
View article: Phase Ib/II trial of Ibrutinib and Nivolumab in Patients with Advanced Refractory Renal Cell Carcinoma
Phase Ib/II trial of Ibrutinib and Nivolumab in Patients with Advanced Refractory Renal Cell Carcinoma Open
BACKGROUND: Although immune checkpoint inhibitor-based therapy has improved the outcomes of many patients with metastatic renal cell carcinoma (mRCC), most eventually develop disease progression. Newer agents that modulate immune response …
View article: Developing a framework for arts in health programs targeting individuals with chronic pain: a mixed-methods study of practitioners
Developing a framework for arts in health programs targeting individuals with chronic pain: a mixed-methods study of practitioners Open
View article: ASO Visual Abstract: Chemotherapy After Diagnosis of Malignant Bowel Obstruction is Associated with Greater Survival for Medicare Patients with Advanced Malignancy
ASO Visual Abstract: Chemotherapy After Diagnosis of Malignant Bowel Obstruction is Associated with Greater Survival for Medicare Patients with Advanced Malignancy Open
View article: Chemotherapy After Diagnosis of Malignant Bowel Obstruction is Associated with Superior Survival for Medicare Patients with Advanced Malignancy
Chemotherapy After Diagnosis of Malignant Bowel Obstruction is Associated with Superior Survival for Medicare Patients with Advanced Malignancy Open
Background Although malignant bowel obstruction (MBO) often is a terminal event, systemic therapies are advocated for select patients to extend survival. This study aimed to evaluate factors associated with receipt of chemotherapy after MB…
View article: Standard Testing Protocols for CO2 Sensors and CO2-based Demand Control Ventilation Systems
Standard Testing Protocols for CO2 Sensors and CO2-based Demand Control Ventilation Systems Open
View article: Homologous Recombination DNA Repair Gene Aberrations—Are We More Alike Than Different?
Homologous Recombination DNA Repair Gene Aberrations—Are We More Alike Than Different? Open
Sabine Schmid, MD; Aurelius Omlin, MD; Celestia Higano, MD; Christopher Sweeney, MD; Nieves Martinez Chanza, MD; Niven Mehra, MD; Malou C. P. Kuppen, MD; Himisha Beltran, MD; Vincenza Conteduca, MD; Daniel Vargas Pivato de Almeida, MD; Fer…
View article: Building a comprehensive mentoring academy for schools of health
Building a comprehensive mentoring academy for schools of health Open
Formal mentoring programs are increasingly recognized as critical for faculty career development. We describe a mentoring academy (MA) developed for faculty across tracks (i.e., researchers, clinicians, educators) within a “school of healt…
View article: Hospital utilization and disposition among patients with malignant bowel obstruction: a population-based comparison of surgical to medical management
Hospital utilization and disposition among patients with malignant bowel obstruction: a population-based comparison of surgical to medical management Open
View article: Palliative Care Training and Decision-Making for Patients with Advanced Cancer: A Comparison of Surgeons and Medical Physicians
Palliative Care Training and Decision-Making for Patients with Advanced Cancer: A Comparison of Surgeons and Medical Physicians Open
View article: Evolution of a functional taxonomy of career pathways for biomedical trainees
Evolution of a functional taxonomy of career pathways for biomedical trainees Open
Several reports have shown that doctoral and postdoctoral trainees in biomedical research pursue diverse careers that advance science meaningful to society. Several groups have proposed 3-tier career taxonomy to showcase these outcomes. Th…
View article: Comparison of common risk stratification indices to predict outcomes among stage IV cancer patients with bowel obstruction undergoing surgery
Comparison of common risk stratification indices to predict outcomes among stage IV cancer patients with bowel obstruction undergoing surgery Open
Background and Objectives Among patients with disseminated malignancy (DMa), bowel obstruction is common with high operative morbidity. Since preoperative risk stratification is critical, we sought to compare three standard risk indices, t…
View article: Increased Rates of Prolonged Length of Stay, Readmissions, and Discharge to Care Facilities among Postoperative Patients with Disseminated Malignancy: Implications for Clinical Practice
Increased Rates of Prolonged Length of Stay, Readmissions, and Discharge to Care Facilities among Postoperative Patients with Disseminated Malignancy: Implications for Clinical Practice Open
Surgical interventions among DMa patients are associated with poorer postoperative outcomes including greater postoperative complications, prolonged length of hospital stay, readmissions, disposition to facilities, and death compared to no…
View article: Three Dimensional Culture of Human Renal Cell Carcinoma Organoids
Three Dimensional Culture of Human Renal Cell Carcinoma Organoids Open
Renal cell carcinomas arise from the nephron but are heterogeneous in disease biology, clinical behavior, prognosis, and response to systemic therapy. Development of patient-specific in vitro models that efficiently and faithfully reproduc…
View article: Current perioperative outcomes for patients with disseminated cancer
Current perioperative outcomes for patients with disseminated cancer Open