Frederick J. Warren
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View article: Dietary Modulation of The Human Small Intestine Metabolome and Microbiome
Dietary Modulation of The Human Small Intestine Metabolome and Microbiome Open
The human gastrointestinal tract (GIT) is central to human physiology, yet our understanding of the metabolite, microbial, and hormonal spatiotemporal dynamics in humans is limited. Here, we employ naso-enteral intubation to generate a spa…
View article: Soluble amylose chains inhibit gelatinisation and retrogradation in waxy corn starch
Soluble amylose chains inhibit gelatinisation and retrogradation in waxy corn starch Open
View article: Unearthing the rhizosphere microbiome recruited by ancestral bread wheat landraces
Unearthing the rhizosphere microbiome recruited by ancestral bread wheat landraces Open
Crop root traits that modulate the soil microbiome can turn the tide of reduced fertility in intensively farmed land by optimising nutrient availability and resilience to environmental stresses. Advantageous genetic diversity that allows a…
View article: Gut Microbial Diversity Impacts Carbohydrate Fermentation by Children With Severe Acute Malnutrition
Gut Microbial Diversity Impacts Carbohydrate Fermentation by Children With Severe Acute Malnutrition Open
View article: Mode of Action of Psyllium in Reducing Gas Production from Inulin and its Interaction with Colonic Microbiota: A 24-hour, Randomized, Placebo-Controlled Trial in Healthy Human Volunteers
Mode of Action of Psyllium in Reducing Gas Production from Inulin and its Interaction with Colonic Microbiota: A 24-hour, Randomized, Placebo-Controlled Trial in Healthy Human Volunteers Open
View article: One Year of Gluten-Free Diet Impacts Gut Function and Microbiome in Celiac Disease
One Year of Gluten-Free Diet Impacts Gut Function and Microbiome in Celiac Disease Open
gov, number: NCT02551289.
View article: Novel amylase genes enable utilisation of resistant starch by bifidobacteria relevant to early-life microbiome development
Novel amylase genes enable utilisation of resistant starch by bifidobacteria relevant to early-life microbiome development Open
Bifidobacterium species and strains are key members of the gut microbiota, appearing soon after birth and persisting into adulthood. Resistant starch is an important dietary substrate for adult-associated bifidobacteria, where its fermenta…
View article: Wheat MYOSIN-RESEMBLING CHLOROPLAST PROTEIN controls B-type starch granule initiation timing during endosperm development
Wheat MYOSIN-RESEMBLING CHLOROPLAST PROTEIN controls B-type starch granule initiation timing during endosperm development Open
Molecular factors that contribute to the diverse spatial and temporal patterns of starch granule initiation between species and organs are poorly understood. Wheat (Triticum sp.) endosperm contains both large A-type granules initiated duri…
View article: The impact of Cas9-mediated mutagenesis of genes encoding potato starch-branching enzymes on starch structural properties and in vitro digestibility
The impact of Cas9-mediated mutagenesis of genes encoding potato starch-branching enzymes on starch structural properties and in vitro digestibility Open
The digestibility of starch is affected by amylose content, and increasing amylopectin chain length which can be manipulated by alterations to genes encoding starch-branching enzymes (SBEs). We investigated the impact of Cas9-mediated muta…
View article: One year of gluten free diet impacts gut function and microbiome in celiac disease
One year of gluten free diet impacts gut function and microbiome in celiac disease Open
BACKGROUND & AIMS Currently, the main treatment option for coeliac disease (CD) is a gluten free diet (GFD). This observational cohort study investigated the impact of CD and 1 year of GFD on gut function and microbiome. METHODS 36 newly d…
View article: Modelling the gut microbiota of children with malnutrition:<i>in vitro</i>models reveal differences in fermentability of widely consumed carbohydrates
Modelling the gut microbiota of children with malnutrition:<i>in vitro</i>models reveal differences in fermentability of widely consumed carbohydrates Open
There is increasing evidence in children suffering from Severe Acute Malnutrition (SAM) that there is disruption of the gut microbiome and low gut microbiota diversity, which may be contributing factors to poor outcomes during nutritional …
View article: Colonic in vitro fermentation of mycoprotein promotes shifts in gut microbiota, with enrichment of Bacteroides species
Colonic in vitro fermentation of mycoprotein promotes shifts in gut microbiota, with enrichment of Bacteroides species Open
View article: The Impact of Cas9-Mediated Mutagenesis of Genes Encoding Potato Starch-Branching Enzymes on Starch Structural Properties and in Vitro Digestibility
The Impact of Cas9-Mediated Mutagenesis of Genes Encoding Potato Starch-Branching Enzymes on Starch Structural Properties and in Vitro Digestibility Open
View article: Investigation of the Link between First-Order Kinetic Models of the in Vitro Digestion of Native Starches and the Accompanying Changes in Their Crystallinity and Structure
Investigation of the Link between First-Order Kinetic Models of the in Vitro Digestion of Native Starches and the Accompanying Changes in Their Crystallinity and Structure Open
View article: The impact of psyllium gelation behaviour on in vitro colonic fermentation properties
The impact of psyllium gelation behaviour on in vitro colonic fermentation properties Open
View article: Mining the A.E. Watkins Wheat Landrace Collection for Variation in Starch Digestibility Using a New High-Throughput Assay
Mining the A.E. Watkins Wheat Landrace Collection for Variation in Starch Digestibility Using a New High-Throughput Assay Open
Breeding for less digestible starch in wheat can improve the health impact of bread and other wheat foods. The application of forward genetic approaches has lately opened opportunities for the discovery of new genes that influence the dige…
View article: Effects of Far-Infrared Radiation Drying on Starch Digestibility and the Content of Bioactive Compounds in Differently Pigmented Rice Varieties
Effects of Far-Infrared Radiation Drying on Starch Digestibility and the Content of Bioactive Compounds in Differently Pigmented Rice Varieties Open
Far infrared radiation (FIR) was applied to six rice varieties with different coloring of the pericarp (purple, red or non-pigment). Changes were determined in amylose content, in gelatinization parameters, in the content of bioactive comp…
View article: The impact of the soluble protein fraction and kernel hardness on wheat flour starch digestibility
The impact of the soluble protein fraction and kernel hardness on wheat flour starch digestibility Open
Wheat is the staple crop for 35% of the world's population, providing a major source of calories, mainly in the form of starch. The digestibility of wheat starch varies between different flours and products. Wheat products that are rapidly…
View article: Development of a high-throughput starch digestibility assay reveals wide variation among the A. E. Watkins wheat landrace collection
Development of a high-throughput starch digestibility assay reveals wide variation among the A. E. Watkins wheat landrace collection Open
Breeding for less digestible starch in wheat can improve the health impact of bread and other wheat foods. Based on an established in vitro starch digestibility assay by Edwards et al. (2019) we developed a high-throughput assay to measure…
View article: The plastidial protein MRC promotes starch granule initiation in wheat leaves but delays B-type granule initiation in the endosperm
The plastidial protein MRC promotes starch granule initiation in wheat leaves but delays B-type granule initiation in the endosperm Open
The spatial and temporal patterns by which starch granules initiate vary greatly between species and organs, but molecular factors that contribute to these diverse patterns are poorly understood. We reveal distinct organ-specific roles of …
View article: Hybrid metagenome assemblies link carbohydrate structure with function in the human gut microbiome
Hybrid metagenome assemblies link carbohydrate structure with function in the human gut microbiome Open
Complex carbohydrates that escape small intestinal digestion, are broken down in the large intestine by enzymes encoded by the gut microbiome. This is a symbiotic relationship between microbes and host, resulting in metabolic products that…
View article: The impact of cyclodextrins on the in vitro digestion of native and gelatinised starch and starch present in a sugar-snap cookie
The impact of cyclodextrins on the in vitro digestion of native and gelatinised starch and starch present in a sugar-snap cookie Open
Cyclodextrins (CDs) are cyclic oligosaccharides composed of α-d-glucose units linked by α-(1,4)-glucosidic bonds. α-CD, β-CD and γ-CD contain 6, 7 or 8 d-glucose units, respectively. CDs can bind to the active site of pancreatic α-amylase …
View article: Loss of starch synthase IIIa changes starch molecular structure and granule morphology in grains of hexaploid bread wheat
Loss of starch synthase IIIa changes starch molecular structure and granule morphology in grains of hexaploid bread wheat Open
Starch synthase III plays a key role in starch biosynthesis and is highly expressed in developing wheat grains. To understand the contribution of SSIII to starch and grain properties, we developed wheat ssIIIa mutants in the elite cultivar…
View article: Starch hydrogels as targeted colonic drug delivery vehicles
Starch hydrogels as targeted colonic drug delivery vehicles Open
Targeted colonic drug delivery systems are needed for the treatment of endemic colorectal pathologies, such as Crohn's disease, ulcerative colitis, and colorectal cancer. These drug delivery vehicles are difficult to formulate, as they nee…
View article: An allelic series of starch-branching enzyme mutants in pea (Pisum sativum L.) reveals complex relationships with seed starch phenotypes
An allelic series of starch-branching enzyme mutants in pea (Pisum sativum L.) reveals complex relationships with seed starch phenotypes Open
A set of mutant pea lines carrying induced mutations within the major seed-expressed starch-branching enzyme gene has been characterised at the molecular, chemical and agronomic levels. Eight of the induced mutations, three of which predic…
View article: Loss of Starch Synthase IIIa changes starch molecular structure and granule morphology in grains of hexaploid bread wheat
Loss of Starch Synthase IIIa changes starch molecular structure and granule morphology in grains of hexaploid bread wheat Open
Starch Synthase III plays a key role in starch biosynthesis and is highly expressed in developing wheat grains. To understand the contribution of SSIII to starch and grain properties, we developed wheat ssIIIa mutants in the elite cultivar…
View article: <i>Bifidobacterium castoris</i> strains isolated from wild mice show evidence of frequent host switching and diverse carbohydrate metabolism potential
<i>Bifidobacterium castoris</i> strains isolated from wild mice show evidence of frequent host switching and diverse carbohydrate metabolism potential Open
Members of the gut microbiota genus Bifidobacterium are widely distributed human and animal symbionts believed to exert beneficial effects on their hosts. However, in-depth genomic analyses of animal-associated species and strains are some…
View article: The impact of the soluble protein fraction and kernel hardness on wheat flour starch digestibility
The impact of the soluble protein fraction and kernel hardness on wheat flour starch digestibility Open
Wheat is the staple crop for 35% of the world’s population, providing a major source of calories for much of the world’s population. Starch is the main source of energy in wheat flour, but the digestibility of wheat starch varies greatly b…
View article: Enzyme kinetic approach for mechanistic insight and predictions of in vivo starch digestibility and the glycaemic index of foods
Enzyme kinetic approach for mechanistic insight and predictions of in vivo starch digestibility and the glycaemic index of foods Open
View article: Psyllium reduces inulin-induced colonic gas production in IBS: MRI and<i>in vitro</i>fermentation studies
Psyllium reduces inulin-induced colonic gas production in IBS: MRI and<i>in vitro</i>fermentation studies Open
Objective Health-promoting dietary fibre including inulin often triggers gastrointestinal symptoms in patients with IBS, limiting their intake. Our aim was to test if coadministering psyllium with inulin would reduce gas production. Design…