Frederick Naftolin
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View article: Long-term effects of 4 years of menopausal hormone therapy on white matter integrity
Long-term effects of 4 years of menopausal hormone therapy on white matter integrity Open
Objectives: To assess the long-term effects of 4 years of menopausal hormone therapy (mHT) on the brain’s white matter architecture in women who initiated mHT within 3 years of menopause onset. Methods: The Kronos Early Estrogen Prevention…
View article: Associations of blood pressure with white matter hyperintensities later in life; influence of short-term menopausal hormone therapy
Associations of blood pressure with white matter hyperintensities later in life; influence of short-term menopausal hormone therapy Open
Objective To assess the association of systolic and diastolic blood pressure (SBP and DBP) in recently menopausal women with white matter hyperintensity (WMH) volume later in life and determine whether short-term menopausal hormone therapy…
View article: Long-term cognitive effects of menopausal hormone therapy: Findings from the KEEPS Continuation Study
Long-term cognitive effects of menopausal hormone therapy: Findings from the KEEPS Continuation Study Open
Background Findings from Kronos Early Estrogen Prevention Study (KEEPS)-Cog trial suggested no cognitive benefit or harm after 48 months of menopausal hormone therapy (mHT) initiated within 3 years of final menstrual period. To clarify the…
Effects of Estradiol and other Selective Estrogen Receptor Modulators on Human Temporal Lobe Cortex Astroglial Cell Spreading Open
Rationale: Astroglial cells (astrocytes), previously considered mere support cells in the central nervous system, are now understood to be key players in integrating neuronal inputs and modulating synaptic density. Astrocytic processes sur…
View article: P-761 Four-dimensional ultrasound using an electronic probe to guide embryo transfer: a feasibility study
P-761 Four-dimensional ultrasound using an electronic probe to guide embryo transfer: a feasibility study Open
Study question Is four-dimensional ultrasound (4D-US) guided embryo transfer feasible and safe? Summary answer 4D trans-abdominal US with electronic probe is feasible and safe and justifies a formal study for non-inferiority to two-dimensi…
View article: Long-term cognitive effects of menopausal hormone therapy: Findings from the KEEPS Continuation Study
Long-term cognitive effects of menopausal hormone therapy: Findings from the KEEPS Continuation Study Open
Background Findings from Kronos Early Estrogen Prevention Study (KEEPS)-Cog trial suggested no cognitive benefit or harm after 48 months of menopausal hormone therapy (mHT) initiated within three years of menopause onset. Long-term effects…
View article: Kisspeptin signaling in astrocytes modulates the reproductive axis
Kisspeptin signaling in astrocytes modulates the reproductive axis Open
Reproduction is safeguarded by multiple, often cooperative, regulatory networks. Kisspeptin signaling, via KISS1R, plays a fundamental role in reproductive control, primarily by regulation of hypothalamic GnRH neurons. We disclose herein a…
CHANGES IN ADIPOSITY AND COGNITION AMONG EARLY POSTMENOPAUSAL WOMEN FOLLOWING HORMONE TREATMENT Open
Evidence suggests that early postmenopausal hormone treatment (MHT) may attenuate metabolic effects on dementia pathogenesis. Using Kronos Early Estrogen Prevention Study (KEEPS) and KEEPS-Continuation data, we investigated heterogeneity i…
View article: Higher systolic and diastolic blood pressures in recently postmenopausal women are associated with greater WMH more than a decade later in the KEEPS Continuation
Higher systolic and diastolic blood pressures in recently postmenopausal women are associated with greater WMH more than a decade later in the KEEPS Continuation Open
Background Higher blood pressure (BP) is associated with greater white matter hyperintensity (WMH) volume, but research is limited in recently menopausal and postmenopausal women. Postmenopausal women have a greater burden of WMH than men …
View article: Higher systolic and diastolic blood pressures in recently postmenopausal women are associated with greater WMH more than a decade later in the KEEPS Continuation
Higher systolic and diastolic blood pressures in recently postmenopausal women are associated with greater WMH more than a decade later in the KEEPS Continuation Open
Background Higher blood pressure (BP) is associated with greater white matter hyperintensity (WMH) volume, but research is limited in recently menopausal and postmenopausal women. Postmenopausal women have a greater burden of WMH than men …
View article: Cardiometabolic outcomes in Kronos Early Estrogen Prevention Study continuation: 14-year follow-up of a hormone therapy trial
Cardiometabolic outcomes in Kronos Early Estrogen Prevention Study continuation: 14-year follow-up of a hormone therapy trial Open
Objective This study aimed to determine long-term cardiometabolic effects of hormone therapies initiated within 3 years of onset of menopause after a 14-year follow-up study of participants of the Kronos Early Estrogen Prevention Study (KE…
View article: P-541 Does the IVF embryo remain at the site of deposition in successful IVF cycles?
P-541 Does the IVF embryo remain at the site of deposition in successful IVF cycles? Open
Study question Does the placement of the IVF embryo differ from the implantation site? Summary answer At five weeks the implanted embryo has not moved in the lateral plane of the endometrial cavity but is slightly lower in the vertical pla…
View article: Higher systolic and diastolic blood pressures in recently postmenopausal women are associated with higher white matter hyperintensity volume more than a decade later in the keeps continuation study
Higher systolic and diastolic blood pressures in recently postmenopausal women are associated with higher white matter hyperintensity volume more than a decade later in the keeps continuation study Open
Background Women have higher rates of hypertension at the time of menopausal transition than men. Although elevated systolic and diastolic blood pressures (SBP and DBP) are risk factors for white matter (WM) injury both in women and men, W…
View article: Factors Influencing Skin Aging and the Important Role of Estrogens and Selective Estrogen Receptor Modulators (SERMs)
Factors Influencing Skin Aging and the Important Role of Estrogens and Selective Estrogen Receptor Modulators (SERMs) Open
The narrative for this overview focuses on updating the factors that influence skin aging and the important role estrogens and selective estrogen receptor modulators (SERMs) play in this process (mainly utilizing journal reports and review…
Estrogen Action and Gut Microbiome Metabolism in Dermal Health Open
Emerging scientific advances in microbial research linking estrogens and the gut-skin microbiome in reference to dermal health are featured in this narrative review of journal reports and reviews from January 2018 through February 2022. Ba…
Lessons from KEEPS: the Kronos Early Estrogen Prevention Study Open
The Kronos Early Estrogen Prevention Study (KEEPS) was a randomized, double-blind, placebo-controlled trial designed to determine the effects of hormone treatments (menopausal hormone treatments [MHTs]) on the progression of carotid intima…
Heart fat and carotid artery atherosclerosis progression in recently menopausal women: impact of menopausal hormone therapy: The KEEPS trial Open
Objective: Heart fat deposition has been linked to atherosclerosis, and both accelerate after menopause. Hormone therapy (HT) may differentially slow heart fat deposition and progression of atherosclerosis, depending on the specific HT age…
View article: Granulosa-Lutein Cell Sirtuin Gene Expression Profiles Differ between Normal Donors and Infertile Women
Granulosa-Lutein Cell Sirtuin Gene Expression Profiles Differ between Normal Donors and Infertile Women Open
Sirtuins are a family of deacetylases that modify structural proteins, metabolic enzymes, and histones to change cellular protein localization and function. In mammals, there are seven sirtuins involved in processes like oxidative stress o…
Impact of menopausal hormone formulations on pituitary-ovarian regulatory feedback Open
Changes in pituitary-ovarian hormones across the menopausal transition have multiple physiological consequences. However, little is known about how the major types of postmenopausal hormone therapy (HT) affect pituitary-ovarian hormonal re…
Cardiovascular health and the menopausal woman: the role of estrogen and when to begin and end hormone treatment Open
Reports have correlated the use of estrogen for the treatment of menopausal symptoms with beneficial effects on the cardiovascular system. Molecular, biochemical, preclinical, and clinical studies have furnished a wealth of evidence in sup…
View article: The Kronos Early Estrogen Prevention Study (KEEPS): what have we learned?
The Kronos Early Estrogen Prevention Study (KEEPS): what have we learned? Open
Objective: The Kronos Early Estrogen Prevention Study (KEEPS) was designed to address gaps in understanding the effects of timely menopausal hormone treatments (HT) on cardiovascular health and other effects of menopause after the prematur…
Faculty Opinions recommendation of Adjunctive azithromycin prophylaxis for cesarean delivery. Open
BACKGROUND-The addition of azithromycin to standard regimens for antibiotic prophylaxis before cesarean delivery may further reduce the rate of postoperative infection.We evaluated the benefits and safety of azithromycin-based extended-spe…
Faculty Opinions recommendation of Danazol treatment for telomere diseases. Open
BACKGROUND-Genetic defects in telomere maintenance and repair cause bone marrow failure, liver cirrhosis, and pulmonary fibrosis, and they increase susceptibility to cancer.Historically, androgens have been useful as treatment for marrow f…
Effects of Oral vs Transdermal Estrogen Therapy on Sexual Function in Early Postmenopause Open
clinicaltrials.gov Identifier: NCT00154180.
Effects of oral versus transdermal menopausal hormone treatments on self-reported sleep domains and their association with vasomotor symptoms in recently menopausal women enrolled in the Kronos Early Estrogen Prevention Study (KEEPS) Open
Objective: This study determined whether two different formulations of hormone therapy (HT): oral conjugated equine estrogens (o-CEE; 0.45 mg/d, n = 209), transdermal 17β-estradiol (t-E2; 50 μg/d, n = 201) plus cyclic progesterone (Prometr…