Frederick W. Miller
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View article: Decreased cigarette smoking may partially explain the increased prevalence of antinuclear antibodies in the United States
Decreased cigarette smoking may partially explain the increased prevalence of antinuclear antibodies in the United States Open
Introduction Despite well-known harmful health effects of smoking, research supports an inverse association with some autoimmune diseases. High-titer antinuclear antibodies (ANA) are associated with autoimmune diseases, and ANA prevalence …
View article: A possible role for immunogenetic factors in myositis developing after vaccination in the pre-covid-19 era
A possible role for immunogenetic factors in myositis developing after vaccination in the pre-covid-19 era Open
Introduction Vaccinations have had a transformative impact on public health, reducing the incidence of many infectious diseases and increasing survival. However, there remains uncertainty about the potential of vaccines to trigger autoimmu…
View article: Autoimmune Thyroid Disease in the United States: Population Prevalence, Diagnosis Rates, and Trends
Autoimmune Thyroid Disease in the United States: Population Prevalence, Diagnosis Rates, and Trends Open
Context Considerable literature regarding autoimmune thyroid disease (AITD) has been published, but population-based prevalence estimates for US AITD are lacking. Objective To define the US population burden of AITD, its prevalence, the re…
View article: Making Room for Play in Lifestyle Medicine
Making Room for Play in Lifestyle Medicine Open
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View article: The role of multicriteria decision analysis in the development of candidate classification criteria for antisynthetase syndrome: analysis from the CLASS project
The role of multicriteria decision analysis in the development of candidate classification criteria for antisynthetase syndrome: analysis from the CLASS project Open
The MCDA-driven candidate classification criteria were consistent with published ASSD literature and yielded high accuracy and validity.
View article: Erratum corrige: Stressful life events are associated with the diagnosis of systemic autoimmune rheumatic diseases among adults
Erratum corrige: Stressful life events are associated with the diagnosis of systemic autoimmune rheumatic diseases among adults Open
View article: Infections preceding diagnosis associated with myositis phenotypes in a national patient registry
Infections preceding diagnosis associated with myositis phenotypes in a national patient registry Open
Antecedent infections, particularly respiratory and gastrointestinal infections may contribute to adult IIM phenotypes. Pneumonia showed the strongest association with myositis phenotypes accompanied by frequent lung disease.
View article: Estimation of prevalence of autoimmune diseases in the United States using electronic health record data
Estimation of prevalence of autoimmune diseases in the United States using electronic health record data Open
BACKGROUNDPrevious epidemiologic studies of autoimmune diseases in the US have included a limited number of diseases or used metaanalyses that rely on different data collection methods and analyses for each disease.METHODSTo estimate the p…
View article: Occupational and Hobby Exposures Associated With Myositis Phenotypes in a National Myositis Patient Registry
Occupational and Hobby Exposures Associated With Myositis Phenotypes in a National Myositis Patient Registry Open
Objective The objective of this study was to investigate occupational and hobby exposures to silica, solvents, and heavy metals and the odds of having the idiopathic inflammatory myopathy (IIM) phenotypes dermatomyositis (DM) and polymyosi…
View article: Neutrophil and mononuclear leukocyte pathways and upstream regulators revealed by serum proteomics of adult and juvenile dermatomyositis
Neutrophil and mononuclear leukocyte pathways and upstream regulators revealed by serum proteomics of adult and juvenile dermatomyositis Open
View article: Clinical Characteristics of Anti‐Synthetase Syndrome: Analysis From the Classification Criteria for Anti‐Synthetase Syndrome Project
Clinical Characteristics of Anti‐Synthetase Syndrome: Analysis From the Classification Criteria for Anti‐Synthetase Syndrome Project Open
Objective Anti‐synthetase syndrome (ASSD) is a rare systemic autoimmune rheumatic disease (SARD) with significant heterogeneity and no shared classification criteria. We aimed to identify clinical and serological features associated with A…
View article: Quantification of autoantibodies using a luminescent profiling method in autoimmune interstitial lung disease
Quantification of autoantibodies using a luminescent profiling method in autoimmune interstitial lung disease Open
Autoantibodies are important for the diagnosis of autoimmune interstitial lung disease (ILD). Standard immunoassays have limitations, including their qualitative nature and/or a narrow dynamic range of detection, hindering the usefulness o…
View article: Environment, Lifestyles, and Climate Change: The Many Nongenetic Contributors to The Long and Winding Road to Autoimmune Diseases
Environment, Lifestyles, and Climate Change: The Many Nongenetic Contributors to The Long and Winding Road to Autoimmune Diseases Open
A critical unanswered question is what is causing the increase in the prevalence of autoimmunity and autoimmune diseases around the world. Given the rapidity of change, this is likely the result of major recent alterations in our exposures…
View article: Discovery of new myositis genetic associations through leveraging other immune-mediated diseases
Discovery of new myositis genetic associations through leveraging other immune-mediated diseases Open
View article: Amphibole asbestos as an environmental trigger for systemic autoimmune diseases
Amphibole asbestos as an environmental trigger for systemic autoimmune diseases Open
View article: OP0005 NAVIGATING COMPLEXITIES OF MULTIPLE POSITIVE MYOSITIS AUTOANTIBODIES: ANALYSIS FROM CLASSIFICATION CRITERIA OF ANTI-SYNTHETASE SYNDROME (CLASS) PROJECT
OP0005 NAVIGATING COMPLEXITIES OF MULTIPLE POSITIVE MYOSITIS AUTOANTIBODIES: ANALYSIS FROM CLASSIFICATION CRITERIA OF ANTI-SYNTHETASE SYNDROME (CLASS) PROJECT Open
Background: Myositis-specific autoantibodies (MSAs) are typically considered mutually exclusive, and multiple positivities using the reference standard, Immunoprecipitation, are increasingly rare. However, other techniques, such as Enzyme-…
View article: POS1281 CLINICAL CHARACTERISTICS OF ANTI-SYNTHETASE SYNDROME: ANALYSIS FROM THE CLASS PROJECT
POS1281 CLINICAL CHARACTERISTICS OF ANTI-SYNTHETASE SYNDROME: ANALYSIS FROM THE CLASS PROJECT Open
View article: American College of Rheumatology White Paper: The Effects of Climate Change on Rheumatic Conditions—An Evolving Landscape and a Path Forward
American College of Rheumatology White Paper: The Effects of Climate Change on Rheumatic Conditions—An Evolving Landscape and a Path Forward Open
Objective Increases in global temperatures and extreme weather events associated with climate change have complex yet poorly understood detrimental impacts on human health. We reviewed the current published literature on climate change–rel…
View article: Author Correction: International Guideline for Idiopathic Inflammatory Myopathy-Associated Cancer Screening: an International Myositis Assessment and Clinical Studies Group (IMACS) initiative
Author Correction: International Guideline for Idiopathic Inflammatory Myopathy-Associated Cancer Screening: an International Myositis Assessment and Clinical Studies Group (IMACS) initiative Open
View article: International Guideline for Idiopathic Inflammatory Myopathy-Associated Cancer Screening: an International Myositis Assessment and Clinical Studies Group (IMACS) initiative
International Guideline for Idiopathic Inflammatory Myopathy-Associated Cancer Screening: an International Myositis Assessment and Clinical Studies Group (IMACS) initiative Open
Adult-onset idiopathic inflammatory myopathy (IIM) is associated with an increased cancer risk within the 3 years preceding and following IIM onset. Evidence- and consensus-based recommendations for IIM-associated cancer screening can pote…
View article: Performance of the 2017 EULAR/ACR Classification Criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups: a scoping review
Performance of the 2017 EULAR/ACR Classification Criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups: a scoping review Open
The 2017 EULAR/ACR classification criteria for adult/juvenile idiopathic inflammatory myopathies (IIM) were established using a data-driven approach by an international group of myositis experts to allow classification of IIM and its major…
View article: Anti-dense fine speckled 70 (DFS70) autoantibodies: correlates and increasing prevalence in the United States
Anti-dense fine speckled 70 (DFS70) autoantibodies: correlates and increasing prevalence in the United States Open
Objective Recent studies report high-titer anti-dense fine speckled 70 (DFS70) autoantibodies in persons with inflammatory conditions, but the clinical significance remains unclear. Our goals were to estimate anti-DFS70 autoantibody preval…
View article: Race/ethnicity-stratified fine-mapping of the MHC locus reveals genetic variants associated with late-onset asthma
Race/ethnicity-stratified fine-mapping of the MHC locus reveals genetic variants associated with late-onset asthma Open
Introduction: Asthma is a chronic disease of the airways that impairs normal breathing. The etiology of asthma is complex and involves multiple factors, including the environment and genetics, especially the distinct genetic architecture a…
View article: Development of a computed tomography calcium scoring technique for assessing calcinosis distribution, pattern and burden in dermatomyositis
Development of a computed tomography calcium scoring technique for assessing calcinosis distribution, pattern and burden in dermatomyositis Open
Objectives To utilize whole-body CT imaging and calcium scoring techniques as tools for calcinosis assessment in a prospective cohort of patients with adult and juvenile dermatomyositis (DM and JDM, respectively). Methods Thirty-one patien…
View article: Reconstructing missing data by comparing interpolation techniques: Applications for long‐term water quality data
Reconstructing missing data by comparing interpolation techniques: Applications for long‐term water quality data Open
Missing data are typical yet must be addressed for proper inferences or expanding datasets to guide our limnological understanding and management of aquatic systems. Interpolation methods (i.e., estimating missing values using known values…
View article: Shared and Distinctive Transcriptomic and Proteomic Pathways in Adult and Juvenile Dermatomyositis
Shared and Distinctive Transcriptomic and Proteomic Pathways in Adult and Juvenile Dermatomyositis Open
Objective Transcript and protein expression were interrogated to examine gene locus and pathway regulation in the peripheral blood of active adult dermatomyositis (DM) and juvenile DM patients receiving immunosuppressive therapies. Methods…
View article: Association of anti-TPM4 autoantibodies with vasculopathic cutaneous manifestations in juvenile dermatomyositis
Association of anti-TPM4 autoantibodies with vasculopathic cutaneous manifestations in juvenile dermatomyositis Open
Objectives AECAs are detected in multiple forms of vasculitis or vasculopathy, including JDM. High levels of tropomyosin alpha-4 chain (TPM4) gene expression in cutaneous lesions and TPM4 protein expression in some endothelial cells (ECs) …
View article: Complement C4 gene copy number variations and polymorphisms, autoantibodies, and clinical manifestations of juvenile dermatomyositis– a multi-center study
Complement C4 gene copy number variations and polymorphisms, autoantibodies, and clinical manifestations of juvenile dermatomyositis– a multi-center study Open
Juvenile dermatomyositis (JDM) is an autoimmune myopathy characterized by rash and muscle weakness. Complement C4 gene copy number (GCN) variation is a known risk factor for JDM. JDM patients often develop autoantibodies. We investigated t…
View article: Data from Forkhead Transcription Factor <i>Foxq1</i> Promotes Epithelial–Mesenchymal Transition and Breast Cancer Metastasis
Data from Forkhead Transcription Factor <i>Foxq1</i> Promotes Epithelial–Mesenchymal Transition and Breast Cancer Metastasis Open
Epithelial–mesenchymal transition (EMT) promotes cancer invasion and metastasis, but the integrative mechanisms that coordinate these processes are incompletely understood. In this study, we used a cross-species expression profiling strate…
View article: Data from Forkhead Transcription Factor <i>Foxq1</i> Promotes Epithelial–Mesenchymal Transition and Breast Cancer Metastasis
Data from Forkhead Transcription Factor <i>Foxq1</i> Promotes Epithelial–Mesenchymal Transition and Breast Cancer Metastasis Open
Epithelial–mesenchymal transition (EMT) promotes cancer invasion and metastasis, but the integrative mechanisms that coordinate these processes are incompletely understood. In this study, we used a cross-species expression profiling strate…